Serial MRIs provide novel insight into natural history of optic pathway gliomas in patients with neurofibromatosis 1
- Laura Sellmer1Email authorView ORCID ID profile,
- Said Farschtschi2,
- Marco Marangoni3,
- Manraj K. S. Heran3,
- Patricia Birch1,
- Ralph Wenzel4,
- Victor-Felix Mautner†2 and
- Jan M. Friedman†1
© The Author(s). 2018
Received: 5 September 2017
Accepted: 17 April 2018
Published: 23 April 2018
Optic pathway gliomas (OPGs) are present in 20% of children with neurofibromatosis 1 (NF1) but are less frequently observed in adults. Our goal was to determine the natural history of OPGs in children and adults with NF1.
We analyzed the features of OPGs and other intracranial lesions on 1775 head MRI scans of 562 unselected adults and children with NF1 collected between 2003 and 2015. 52 (9.3%) of 562 patients in this study had an OPG diagnosed on their MRI. The median age at first scan with an OPG present was 12.7 years. Of the 52 OPG patients, the intraorbital optic nerves were affected in 29 patients (56%), the prechiasmatic optic nerves were affected in 32 patients (62%), the optic chiasm was affected in 17 patients (33%) and the optic radiations were affected in 19 patients (37%). 29 patients had two or more areas affected. One patient had a newly-appearing OPG, and 1 patient showed progression. The rate of progression over 5 years was 2.4% (95% CI: 0.4% to 16%). Four patients showed partial regression of their OPGs, but we observed no case of complete regression during this study. The rate of regression over 5 years was 8.9% (95% confidence intervals: 2.8% to 26%). We found the presence of UBOs and the presence of OPGs in individual patients to be highly associated (p = 0.0061).
OPGs are more common in older adults with NF1 than previously thought. The occurrences of unidentified bright objects (UBOs) and asymptomatic OPGs are associated with each other. This suggests the possibility that OPGs that remain asymptomatic may differ pathogenically from those that become symptomatic.
NF1 is a dominantly inherited multisystem disorder affecting 1 in 3500 individuals . It is caused by mutations in NF1, a large gene located on the long arm of chromosome 17 [2–4]. NF1 is a neurocutaneous disorder characterized by the development of dermal and plexiform neurofibromas and café-au-lait spots . One of the most serious manifestations of NF1 in children is the development of optic pathway gliomas (OPGs). These tumours affect approximately 20% of all children with NF1  and can lead to a loss of vision, proptosis, or precocious puberty. Fortunately, however, these tumours remain asymptomatic in the majority of affected children. It is currently not recommended to screen children with NF1 routinely by MRI for optic pathway gliomas, as the vast majority of tumours are indolent, and early detection does not improve visual outcomes .
Factors such as tumour location  and changes in tissue microstructure  have been proposed to predict which OPGs will become symptomatic; however, these findings remain controversial. This is largely because the natural history of OPGs in people with NF1 has not been thoroughly characterized: There are no large studies of adult NF1 patients with OPGs, and we do not even know the prevalence of this tumour in adults with NF1.
In this study, we used routine MRIs to investigate the prevalence and natural history of optic pathway gliomas in children and adults with NF1.
All NF1 patients seen in the NF outpatient department of the University Hospital Hamburg-Eppendorf between 2003 and 2015 were offered whole-body and head MRIs as part of a routine tumour monitoring protocol . Since MRIs were offered to all patients independent of their clinical symptoms, the images are representative of the patient population seen in the clinic. Informed consent was obtained from all subjects, and the ethical committees of the Medical Chamber of Hamburg and the University of British Columbia approved the study.
Magnetic resonance imaging (MRI)
To evaluate the extent of optic gliomas, we defined four locations: intraorbital optic nerves, prechiasmatic optic nerves, chiasm, and optic tracts/optic radiations. A glioma of the optic pathway was diagnosed if there was hyperintensity on T2-weighted images or if they enhanced after contrast injection. A tumour was defined as being multifocal of it was present in two or more unconnected sections of the optic pathway.
Based on the 1775 clinical MRI reports, a list of patients was generated who had been clinically diagnosed with OPG. All head MRIs from these patients were re-evaluated by two neuroradiologists in Canada (M.M. and M.K.S.H.), and the presence of OPGs in each individual MRI study was established by consensus using the criteria described above.
Features extracted from MRIs and clinical records
Clinical features extracted from the MRI reports of all 562 patients included: Presence of OPG, presence of non-optic gliomas, presence of unidentified bright objects (UBOs) and presence of plexiform neurofibromas (PNs) on the corresponding whole-body MRI examination. The presence of subcutaneous neurofibromas in patients with OPG was determined from the corresponding whole-body MRI.
The last visual acuity measurements during the study period were used to determine the presence or absence of loss of vision and visual field defects.
Descriptive statistical analysis
Patients were divided into 10-year age groups and counted only once per age group. 95% confidence intervals of OPG prevalence were calculated as ±1.96 standard deviations of a binomial distribution.
Multiple logistic or linear regression was performed to identify factors associated with OPG presence or volume. Natural log transformation was applied to the tumour volumes to achieve normal distribution for linear regression. Predictor variables for logistic regression with presence of OPG as the outcome variable were age at first scan with OPG present and the presence of non-optic gliomas, UBOs, or plexiform neurofibromas. Predictor variables for analysis of OPG volume were age at first scan with OPG present, and the presence of non-optic gliomas, UBOs, plexiform neurofibromas or subcutaneous neurofibromas.
We used the Kaplan-Meier method to calculate the cumulative rates and 95% confidence intervals of OPG progression or regression within 5 years of first MRI diagnosis. The log-rank test was used to assess differences between the rates of progression or regression in patients under 20 years of age and those over 20 years of age. These analyses were performed with IBM SPSS Statistics version 24.
UBO prevalence in patients with or without OPGs was compared using the Mantel-Haenszel test. Each patient was counted once after stratification into a single age group for this analysis: 0–9.99, 10.0–19.99, 20.0–29.99, 30.0–39.99 or ≥ 40 years old at the time of first MRI or first MRI on which an OPG was seen in the study. The calculation was performed using IBM SPSS Statistics version 24.
Results with p ≤ 0.05 were considered to be statistically significant.
562 NF1 patients (264 males and 298 females) were included in this study. A total of 1775 whole-body and head MRI examinations were performed on these patients between 2003 and 2015, with a median follow-up time of 3.7 years (range 0 to 13.0 years) and a median number of 3 scans per person (range 1 to 13 scans). At the time of the MRI scan, patient ages ranged from 0.4 to 72.8 years. During the study, 75 patients were lost to follow-up or died of a reason unrelated to OPG, equaling a dropout rate of 13.3%.
Prevalence of optic pathway glioma per age group
Features of symptomatic optic pathway gliomas in 17 of 52 OPG patients. OPG location indicates extent after shrinkage in patients with regression or extent after growth in patients with progression of the tumour. Details on asymptomatic OPG patients can be found in Additional file 1: Table S1
Age at first scan (years)
Changes during follow-up
Age at symptom onset (In years)
Changes after treatment
Left intraorbital ON
Reduced vision in left eye
Reduced vision and visual field defects in both eyes
Tumour shrinkage and improvement of vision
Right prechiasmatic ON, chiasm, right radiations
Reduced vision in both eyes, visual field defect in right eye, premature puberty
Vincristin, carboplatine, leuprorelin
Right and left intraorbital ON
Reduced vision in left eye, visual field defect in left eye, hydrocephalus
Right and left intraorbital ON
Reduced vision in both eyes
Right and left prechiasmatic ON, chiasm, right and left radiations
Reduced vision in right and left eye, visual field defects in both eyes
Left prechiasmatic ON, chiasm, right and left radiations
Blind in left eye, reduced vision and visuals field defect in right eye
Right and left intraorbital ON, right and, left prechiasmatic ON, chiasm, right and left radiations
Reduced vision in both eyes, visual field defect in left eye
Right and left intraorbital ON, right and left prechiasmatic ON
No contrast used
Blind in both eyes
Right prechiasmatic ON, chiasm
Reduced vision in right eye
Right intraorbital ON, right prechiasmatic ON, chiasm, right radiations
Blind in right eye, reduced vision and visual field defect in left eye
Left prechiasmatic ON, chiasm, left radiations
No contrast used
Blind in left eye, reduced vision and visual field defect in right eye
Radiation and surgery
Left prechiasmatic ON
Reduced vision in both eyes, visual field defects in both eyes, diffuse hydrocephalus
Right and left intraorbital ON, right and left prechiasmatic ON, chiasm, right radiations
Reduced vision in right and left eye, visual field defect in right eye, diffuse hydrocephalus
Right intraorbital ON, right prechiasmatic ON, chiasm
Reduced vision in both eyes, visual field defects in both eyes
Left intraorbital ON
Blind in left eye
Right prechiasmatic ON
Reduced vision in right eye
Description of OPGs
An overview of the clinical features of all OPGs is presented in Table 1 (symptomatic patients) and Additional file 1: Table S1 (asymptomatic patients). Of the 48 gliomas that affected the optic nerves, 29 were unilateral and 19 were bilateral. 12 of 52 OPGs were multifocal, equaling a total number of 64 tumours. Tumour volumes per patient ranged from 95.4 mm3 to 9255 mm3, with a median tumour volume of 879 mm3. 45 of the 52 OPG patients had their MRI scans performed with contrast enhancement: 34 of these patients showed no enhancement, 2 patients showed diffuse enhancement, 3 patients showed mild enhancement and 6 patients showed avid enhancement of their tumours. The clinical head and whole-body MRI reports included in this study noted the presence of UBOs in 246 (43.8%) and plexiform neurofibromas in 321 (57.1%) patients. Subcutaneous neurofibromas were seen in 22 (42%) of the 52 NF1 patients with OPG (these tumours were only evaluated in patients with OPG).
17 of the 52 patients with OPGs were symptomatic. All experienced vision decline, while 13 also had visual field defects. Patients with symptomatic OPGs received one MRI per year, with ophthalmologic assessments in between. During those assessments visual acuity testing, visual field testing and occasionally OPG was performed. Of these 17 patients with symptomatic OPG, 7 were treated: Five received chemotherapy with vincristine and carboplatin, one underwent surgery, and one underwent surgery and radiation. Surgery was reserved for cases with pronounced visual decline and rapidly growing tumours. The radiation treatment performed on one patient took place in 1996 before the high risk of secondary malignancy in people with NF1 who are treated with radiotherapy was appreciated. One patient (Patient 13) experienced premature puberty and was treated with leuprorelin.
We investigated the prevalence of symptomatic and asymptomatic OPGs per 10-year age group (Fig. 1b). Asymptomatic OPGs are very prevalent in young children, and their frequency decreases with increasing age until adulthood. In contrast, the prevalence of symptomatic tumours remains stable throughout all age groups.
Non-optic gliomas were seen in 34 of the 562 NF1 patients included in this study: nine (17%) of the 52 patients with OPG but only 25 (5.15%) of 485 without OPG (p = 0.001).
There was only one patient (Patient 8) with an optic glioma that appeared during the course of this study (Fig. 2). After its first appearance at 2.0 years of age, the glioma was avidly enhancing. 3.5 years later the enhancement decreased from avid to diffuse. The patient remained asymptomatic throughout follow-up.
Only one of the 52 NF1 patients with OPG (Patient 37) had a tumour that increased in volume during the study period (Fig. 3). The rate of progression was estimated as 2.4% over 5 years (95% confidence intervals: 0.4% to 16%). There was no significant difference in the cumulative rates of progression between children (< 20 years of age) and adults (≥20 years of age) (p = 0.42).
Four patients (Patients 3, 24 and 27) with OPG showed spontaneous shrinkage of their tumours during the period of observation (for Patient 3 see Fig. 4). The rate of regression was estimated as 8.9% over 5 years (95% confidence intervals: 2.8% to 26%). As with progression, there was no significant difference in the cumulative rates of regression between children and adults (p = 0.17). All instances of OPG regression occurred in patients under the age of 20 years, although only 54% of the patient-years of observation took place in this age group (p = 0.002). In at least three of these four patients (Patients 24, 27 and 48), the OPG showed enhancement prior to its shrinkage (no contrast enhanced studies were performed in Patient 3 after his first scan).
Association of OPG presence and volume with other features observed on MRI examination
We performed multiple regression analysis to determine factors associated with OPG presence or volume in individual patients (see Additional file 2: Table S2). The presence of UBOs (OR = 2.4, 95% CI = 1.2 to 4.8) and the presence of non-optic gliomas (OR = 4.8, 95% CI = 2.0 to 12) each was associated with the presence of OPGs in a patient. Age at first scan was negatively associated with the presence of an OPG (OR = 0.96, 95% CI = 0.96 to 0.99). None of the independent variables significantly predicted tumour volume.
Frequency (and percentage) of UBOs among NF1 patients with or without OPG by 10-year age group
Any OPG Present
Asymptomatic OPG Present
0 to 9.99 years
10.0 to 19.99 years
20.0 to 29.99 years
30.0 to 39.99 years
40.0 years and above
In this study we report the largest series of head MRIs described to date in unselected NF1 patients. Most previous studies have used convenience samples to estimate the prevalence of OPGs in children with NF1 [12, 13]. This approach, however, carries the inherent bias of the patients being selected for having clinical symptoms that required them to undergo imaging. In our study, every patient seen in the NF outpatient department was offered MRI, so our series is an unbiased representation of the patients seen in the clinic. Blanchard et al. recently performed a prospective head MRI study of 306 children with NF1 under 6 years of age and found the prevalence of OPG to be 14.7% (95% confidence interval: 11.0% to 19.3%), with 80% of patients being asymptomatic . Other authors found similar prevalences in children, ranging from 15%–18% [12, 14, 15]. We found a somewhat higher prevalence (22%) among children with NF1 under 10 years of age: This might be due to different diagnostic criteria (T2 hyperintensity without consideration of thickness or tortuosity of the optic nerve) used in our study compared to the previous studies.
The prevalence of OPG in older children and adults with NF1 is lower than in young children but has rarely been evaluated. One retrospective study by Créange et al. found the prevalence in 138 individuals with NF1 over 18 years of age to be 5.8% . In concordance with this finding, we found the prevalence in adults over 19.9 years of age to be 4.9% (95% confidence interval: 3.3% to 7.2%).
The decline in prevalence of OPG from childhood to adulthood might be explained in several different ways. Firstly, it is important to note that most OPGs are asymptomatic and are never confirmed by biopsy in people with NF1 [17, 18]. Optic nerve tortuosity and optic nerve sheath thickening are frequent in children with NF1 who do not have OPG , and it is not known if T2 hyperintensity or MRI enhancement of the optic nerves can occur in the absence of other evidence of neoplasia in this setting. Thus, it is possible that some OPGs diagnosed by MRI in children with NF1 are not true neoplasms.
Alternatively, there might be increased mortality in individuals with optic tumours, so that children with OPG are less likely to survive into adulthood. However, a study by Guillamo et al. showed that having an OPG is not a risk factor for premature death of NF1 patients .
It has been shown that having an OPG predisposes to the development of non-optic gliomas , which are associated with increased morbidity . We found a strong correlation between presence of OPG and presence of non-optic gliomas: however, this cannot account for the strong decline of OPG prevalence with increasing age seen in our study, as no patients dies from non-optic glioma.
Lastly, tumours might regress spontaneously, as has been described many times for OPG in case reports of children with NF1 (see Additional file 3: Table S3 and [22–24]). Regression seems to occur mostly in tumours involving the optic chiasm, but may also sometimes occur in other sections of the optic pathway. In our study, we identified no instances of complete regression of an OPG but 4 cases of partial regression (see Additional file 1: Table S1). All of the patients in this study who showed tumour regression were under 20 years of age when this occurred. All three of the patients whose MRIs included contrast showed avid enhancement before regression and mild to no enhancement after regression had stopped.
Among the 17 symptomatic OPG patients, 7 were treated. Three of these 7 patients (Patients 5, 13 and 17) received chemotherapy soon after symptom onset, and all showed vision improvement after treatment. Of the remaining 4 patients, the age at symptom onset is unknown for 2 patients, 1 patient received surgery and radiation followed by a decline in vision, and 1 patient received chemotherapy 6 years after symptom onset, followed by stable vision. This may indicate a benefit to starting treatment early after symptom onset; however, our sample is too small to show any definitive benefit. Further research is required to investigate whether early treatment of symptomatic OPG is beneficial in NF1.
Sex has been suggested as a determinant of which NF1 OPGs become symptomatic. Females were reported to receive MRI for visual symptoms significantly more often than males and were 3 times more likely to undergo treatment for visual decline in one study  but not in another . We did not see a difference in tumour location, tumour frequency symptom status or frequency of treatment initiation between males and females.
We observed a strong association between the presence of OPG and the presence of UBOs after stratification by age (Table 2); this association was also seen when the analysis was restricted to asymptomatic OPGs. Regression analysis showed a similar association between the presence of OPG and UBOs after adjustment for the effect of age (Additional file 2: Table S2).
There are several parallels between UBOs and asymptomatic OPGs: their glial origin, benign nature, usual spontaneous involution, frequent development in early childhood and very infrequent development later in life, and decreased prevalence with increasing age. UBOs are thought to be areas of immature myelin or intramyelinic edema [11, 26, 27] and not neoplasms. All studies investigating the histology of OPGs in NF1 patients only include symptomatic patients, as biopsy or surgical removal is not performed in asymptomatic patients. It has generally been assumed that the pathology (and pathogenesis) of symptomatic and asymptomatic OPG is the same in patients with NF1, but there is no direct evidence supporting this assumption. If many asymptomatic OPGs are actually areas of immature myelin instead of true neoplasms, it will change our understanding of NF1 pathology.
Recently, the idea that pediatric gliomas in general are neurodevelopmental disorders has gained traction. Pediatric gliomas vary from their adult counterparts in location (posterior fossa and optic pathway in children, supratentorial compartment in adults), their usual type (low-grade pilocytic astrocytoma in children, high-grade glioblastoma in adults) and their potential for malignant transformation (low in children, high in adults) . OPGs in NF1 patients are often diagnosed in very young children, and few, if any, cases arise in adults. This stands in contrast to non-optic gliomas in NF1, which do often arise in adults [29, 30].
Our study has several limitations. First of all, our study population might not be representative of the NF1 population as a whole. We cannot rule out referral bias or the possibility that symptomatic patients are more likely to consent to participate in an MRI study than asymptomatic patients. Also, patients with more severe phenotypes are likely to receive more frequent clinical follow-up and repeat imaging than patient with less severe manifestations. Another important factor is the diagnosis of OPG based on imaging. There are no generally-accepted diagnostic guidelines for OPGs in NF1 patients, and diagnosis is based on clinical judgment.
This is the largest prospective study of unselected head and whole-body MRIs ever performed in patients with NF1 . It is also the first study that quantifies the frequency of OPG progression and regression. The observations that these lesions are extraordinarily frequent in children but are usually asymptomatic and remain so throughout their course and that many appear to regress spontaneously in late childhood or adolescence support our current clinical practice of only obtaining frequent follow-up MRIs in patients who have symptomatic OPGs or tumours that are growing or producing a mass effect. Our data are important for scientists working to understand the pathogenesis of NF1-associated lesions and for clinicians assessing NF1 patients who have OPG.
This study was funded by a grant from the Bundesverband Neurofibromatose e.V.
Availability of data and materials
The dataset supporting the conclusions of this article is included in full within the article.
JMF and VFM contributed to the study planning. VFM, SF and RW were involved in image collection and provided clinical patient care. LS, MM, MKSH, PB, JMF and VFM were responsible for data analysis and data visualization. LS, SF, JMF and VFM were involved in writing and reviewing the manuscript. All authors read and approved the final manuscript.
Ethics approval and consent to participate
The ethical committees of the Medical Chamber in Hamburg and the Research Ethics Board of the University of British Columbia approved the study. Written consent was obtained from all study participants before study begin. All data were de-identified before analysis.
The authors declare that they have no competing interests.
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- Lammert M, Friedman JM, Kluwe L, Mautner V-F. Prevalence of neurofibromatosis 1 in German children at elementary school enrollment. Arch Dermatol. 2005;141:71–4.View ArticlePubMedGoogle Scholar
- Gutmann DH, Collins FS. The neurofibromatosis type 1 gene and its protein product, neurofibromin. Neuron. 1993;10:335–43.View ArticlePubMedGoogle Scholar
- Cawthon RM, Weiss R, Xu GF, Viskochil D, Culver M, Stevens J, Robertson M, Dunn D, Gesteland R, O’Connell P, White R, Bader JL, Miller RW, Birnboim HC, Buchberg AM, Bedigian HG, Jenkins NA, Copeland NG, Cavenee WK, Dryja TP, Phillips RA, Benedict WF, Godbout R, Gallie BL, Murphree AL, Strong LC, White RL, Cawthon RM, O’Connell P, Buchberg AM, et al. A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations. Cell. 1990;62:193–201.View ArticlePubMedGoogle Scholar
- Wallace MR, Marchuk DA, Andersen LB, Letcher R, Odeh HM, Saulino AM, Fountain JW, Brereton A, Nicholson J, Mitchell AL. Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. Science (80- ). 1990;249:181–6.View ArticleGoogle Scholar
- Jett K, Friedman JM. Clinical and genetic aspects of neurofibromatosis 1. Genet Med. 2010;12:1–11.View ArticlePubMedGoogle Scholar
- Listernick R, Louis DN, Packer RJ, Gutmann DH. Optic pathway gliomas in children with neurofibromatosis 1: consensus statement from the NF1 optic pathway glioma task force. Ann Neurol. 1997;41:143–9.View ArticlePubMedGoogle Scholar
- Kalin-Hajdu E, Décarie J-C, Marzouki M, Carret A-S, Ospina LH. Visual acuity of children treated with chemotherapy for optic pathway gliomas. Pediatr Blood Cancer. 2014;61:223–7.View ArticlePubMedGoogle Scholar
- Fisher MJ, Loguidice M, Gutmann DH, Listernick R, Ferner RE, Ullrich NJ, Packer RJ, Tabori U, Hoffman RO, Ardern-Holmes SL, Hummel TR, Hargrave DR, Bouffet E, Charrow J, Bilaniuk LT, Balcer LJ, Liu GT. Visual outcomes in children with neurofibromatosis type 1-associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis. Neuro-Oncology. 2012;14:790–7.View ArticlePubMedPubMed CentralGoogle Scholar
- de Blank PMK, Berman JI, Liu GT, Roberts TPL, Fisher MJ. Fractional anisotropy of the optic radiations is associated with visual acuity loss in optic pathway gliomas of neurofibromatosis type 1. Neuro-Oncology. 2013;15:1088–95.View ArticlePubMedPubMed CentralGoogle Scholar
- National Institutes of Health: National Institutes of Health consensus development conference statement: neurofibromatosis. Bethesda: Neurofibromatosis; July 13–15, 1987 Volume 1; 1988. p. 172–178.Google Scholar
- Ferraz-Filho JRL, José da Rocha A, Muniz MP, Souza AS, Goloni-Bertollo EM, Pavarino-Bertelli EC, Pavarino-Bertelli ÉC. Unidentified bright objects in neurofibromatosis type 1: conventional MRI in the follow-up and correlation of microstructural lesions on diffusion tensor images. Eur J Paediatr Neurol. 2012;16:42–7.View ArticlePubMedGoogle Scholar
- Prada CE, Hufnagel RB, Hummel TR, Lovell AM, Hopkin RJ, Saal HM, Schorry EK. The use of magnetic resonance imaging screening for optic pathway gliomas in children with Neurofibromatosis type 1. J Pediatr. 2015;167:851–856.e1.View ArticlePubMedGoogle Scholar
- Blanchard G, Lafforgue MP, Lion-François L, Kemlin I, Rodriguez D, Castelnau P, Carneiro M, Meyer P, Rivier F, Barbarot S, Chaix Y. Systematic MRI in NF1 children under six years of age for the diagnosis of optic pathway gliomas. Study and outcome of a French cohort. Eur J Paediatr Neurol. 2016;20:275–81.View ArticlePubMedGoogle Scholar
- Blazo MA, Lewis RA, Chintagumpala MM, Frazier M, McCluggage C, Plon SE. Outcomes of systematic screening for optic pathway tumors in children with Neurofibromatosis type 1. Am J Med Genet Part A. 2004;127A:224–9.View ArticlePubMedGoogle Scholar
- Levin MH, Armstrong GT, Broad JH, Zimmerman R, Bilaniuk LT, Feygin T, Li Y, Liu GT, Fisher MJ. Risk of optic pathway glioma in children with neurofibromatosis type 1 and optic nerve tortuosity or nerve sheath thickening. Br J Ophthalmol. 2016;100:510–4.View ArticlePubMedGoogle Scholar
- Créange A, Zeller J, Rostaing-Rigattieri S, Brugières P, Degos JD, Revuz J, Wolkenstein P. Neurological complications of neurofibromatosis type 1 in adulthood. Brain. 1999;122:473–81.View ArticlePubMedGoogle Scholar
- Segal L, Darvish-Zargar M, Dilenge ME, Ortenberg J, Polomeno RC. Optic pathway gliomas in patients with neurofibromatosis type 1: follow-up of 44 patients. J AAPOS. 2010;14:155–8.View ArticlePubMedGoogle Scholar
- King A, Listernick R, Charrow J, Piersall L, Gutmann DH. Optic pathway gliomas in neurofibromatosis type 1: the effect of presenting symptoms on outcome. Am J Med Genet A. 2003;122A:95–9.View ArticlePubMedGoogle Scholar
- Ji J, Shimony J, Gao F, McKinstry RC, Gutmann DH. Optic nerve tortuosity in children with neurofibromatosis type 1. Pediatr Radiol. 2013;43:1336–43.View ArticlePubMedPubMed CentralGoogle Scholar
- Guillamo J-S, Creange A, Kalifa C, Grill J, Rodriguez D, Doz F, Barbarot S, Zerah M, Sanson M, Bastuji-Garin S, Wolkenstein P. Prognostic factors of CNS tumours in Neurofibromatosis 1 (NF1): a retrospective study of 104 patients. Brain. 2003;126:152–60.View ArticlePubMedGoogle Scholar
- Friedman JM, Birch P. An association between optic glioma and other tumours of the central nervous system in neurofibromatosis type 1. Neuropediatrics. 1997;28:131–2.View ArticlePubMedGoogle Scholar
- Piccirilli M, Lenzi J, Delfinis C, Trasimeni G, Salvati M, Raco A. Spontaneous regression of optic pathways gliomas in three patients with neurofibromatosis type I and critical review of the literature. Childs Nerv Syst. 2006;22:1332–7.View ArticlePubMedGoogle Scholar
- Brzowski AE, Bazan C, Mumma JV, Ryan SG. Spontaneous regression of optic glioma in a patient with neurofibromatosis. Neurology. 1992;42(3 Pt 1):679–81.View ArticlePubMedGoogle Scholar
- Parsa CF, Hoyt CS, Lesser RL, Weinstein JM, Strother CM, Muci-Mendoza R, Ramella M, Manor RS, Fletcher WA, Repka MX, Garrity JA, Ebner RN, Monteiro ML, McFadzean RM, Rubtsova IV, Hoyt WF. Spontaneous regression of optic gliomas: thirteen cases documented by serial neuroimaging. Arch Ophthalmol. 2001;119:516–29.View ArticlePubMedGoogle Scholar
- Diggs-Andrews KA, Brown JA, Gianino SM, Rubin JB, Wozniak DF, Gutmann DH. Sex is a major determinant of neuronal dysfunction in neurofibromatosis type 1. Ann Neurol. 2014;75:309–16.View ArticlePubMedPubMed CentralGoogle Scholar
- DiPaolo DP, Zimmerman RA, Rorke LB, Zackai EH, Bilaniuk LT, Yachnis AT. Neurofibromatosis type 1: pathologic substrate of high-signal-intensity foci in the brain. Radiology. 1995;195:721–4.View ArticlePubMedGoogle Scholar
- Billiet T, Mädler B, D’Arco F, Peeters R, Deprez S, Plasschaert E, Leemans A, Zhang H, den Bergh BV, Vandenbulcke M, Legius E, Sunaert S, Emsell L. Characterizing the microstructural basis of “unidentified bright objects” in neurofibromatosis type 1: a combined in vivo multicomponent T2 relaxation and multi-shell diffusion MRI analysis. NeuroImage Clin. 2014;4:649–58.View ArticlePubMedPubMed CentralGoogle Scholar
- Baker SJ, Ellison DW, Gutmann DH. Pediatric gliomas as neurodevelopmental disorders. Glia. 2016;64(6):879–95.PubMedGoogle Scholar
- Gutmann DH, Rasmussen SA, Wolkenstein P, MacCollin MM, Guha A, Inskip PD, North KN, Poyhonen M, Birch PH, Friedman JM. Gliomas presenting after age 10 in individuals with neurofibromatosis type 1 (NF1). Neurology. 2002;59:759–61.View ArticlePubMedGoogle Scholar
- Sellmer L, Farschtschi S, Marangoni M, Heran MKS, Birch P, Wenzel R, Friedman JM, Mautner V-F. Non-optic glioma in adults and children with neurofibromatosis 1. Orphanet J Rare Dis. 2017;12:34.View ArticlePubMedPubMed CentralGoogle Scholar
- Trevisson E, Cassina M, Opocher E, Vicenzi V, Lucchetta M, Parrozzani R, Miglionico G, Mardari R, Viscardi E, Midena E, Clementi M. Natural history of optic pathway gliomas in a cohort of unselected patients affected by Neurofibromatosis 1. J Neuro-Oncol. 2017;134:279–87.View ArticleGoogle Scholar