Table 1 Features of symptomatic optic pathway gliomas in 17 of 52 OPG patients. OPG location indicates extent after shrinkage in patients with regression or extent after growth in patients with progression of the tumour. Details on asymptomatic OPG patients can be found in Additional file 1: Table S1
Patient number | Sex | Age at first scan (years) | OPG location | Enhancement | Changes during follow-up | Symptoms | Age at symptom onset (In years) | Treatment | Changes after treatment |
|---|---|---|---|---|---|---|---|---|---|
4 | F | 19.7 | Left intraorbital ON | No | Stable | Reduced vision in left eye | 3 | – | – |
5 | F | 10.8 | Chiasm | Avid | Stable | Reduced vision and visual field defects in both eyes | 11 | Vincristin, carboplatine | Tumour shrinkage and improvement of vision |
13 | M | 6.2 | Right prechiasmatic ON, chiasm, right radiations | Avid | Stable | Reduced vision in both eyes, visual field defect in right eye, premature puberty | 6 | Vincristin, carboplatine, leuprorelin | Improved vision |
14 | M | 25 | Right and left intraorbital ON | No | Stable | Reduced vision in left eye, visual field defect in left eye, hydrocephalus | 4 | – | – |
17 | F | 8.7 | Right and left intraorbital ON | No | Stable | Reduced vision in both eyes | 5 | Vincristin, carboplatine | Improved vision |
18 | M | 30.3 | Right and left prechiasmatic ON, chiasm, right and left radiations | Diffuse | Stable | Reduced vision in right and left eye, visual field defects in both eyes | 6 | – | – |
29 | M | 18.1 | Left prechiasmatic ON, chiasm, right and left radiations | Mild | Stable | Blind in left eye, reduced vision and visuals field defect in right eye | 6 | – | – |
30 | F | 15.3 | Right and left intraorbital ON, right and, left prechiasmatic ON, chiasm, right and left radiations | Diffuse | Stable | Reduced vision in both eyes, visual field defect in left eye | Unknown | Vincristin, carboplatine | Decreased vision |
31 | M | 48.9 | Right and left intraorbital ON, right and left prechiasmatic ON | No contrast used | Stable | Blind in both eyes | 1.5 | – | – |
33 | F | 34.6 | Right prechiasmatic ON, chiasm | No | Stable | Reduced vision in right eye | 3 | – | – |
35 | F | 25.4 | Right intraorbital ON, right prechiasmatic ON, chiasm, right radiations | Mild | Stable | Blind in right eye, reduced vision and visual field defect in left eye | 4 | – | – |
39 | F | 15.1 | Left prechiasmatic ON, chiasm, left radiations | No contrast used | Stable | Blind in left eye, reduced vision and visual field defect in right eye | 11 | Radiation and surgery | Decreased vision |
41 | F | 34.5 | Left prechiasmatic ON | No | Stable | Reduced vision in both eyes, visual field defects in both eyes, diffuse hydrocephalus | 5 | – | – |
43 | M | 12.3 | Right and left intraorbital ON, right and left prechiasmatic ON, chiasm, right radiations | No | Stable | Reduced vision in right and left eye, visual field defect in right eye, diffuse hydrocephalus | 6 | Vincristin, carboplatine | Stable vision |
45 | M | 46.1 | Right intraorbital ON, right prechiasmatic ON, chiasm | No | Stable | Reduced vision in both eyes, visual field defects in both eyes | 4 | – | – |
49 | M | 44.6 | Left intraorbital ON | Avid | Stable | Blind in left eye | 34 | Surgery | Decreased vision |
50 | F | 25.3 | Right prechiasmatic ON | No | Stable | Reduced vision in right eye | Unknown | – | – |