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Table 1 Features of symptomatic optic pathway gliomas in 17 of 52 OPG patients. OPG location indicates extent after shrinkage in patients with regression or extent after growth in patients with progression of the tumour. Details on asymptomatic OPG patients can be found in Additional file 1: Table S1

From: Serial MRIs provide novel insight into natural history of optic pathway gliomas in patients with neurofibromatosis 1

Patient number Sex Age at first scan (years) OPG location Enhancement Changes during follow-up Symptoms Age at symptom onset (In years) Treatment Changes after treatment
4 F 19.7 Left intraorbital ON No Stable Reduced vision in left eye 3
5 F 10.8 Chiasm Avid Stable Reduced vision and visual field defects in both eyes 11 Vincristin, carboplatine Tumour shrinkage and improvement of vision
13 M 6.2 Right prechiasmatic ON, chiasm, right radiations Avid Stable Reduced vision in both eyes, visual field defect in right eye, premature puberty 6 Vincristin, carboplatine, leuprorelin Improved vision
14 M 25 Right and left intraorbital ON No Stable Reduced vision in left eye, visual field defect in left eye, hydrocephalus 4
17 F 8.7 Right and left intraorbital ON No Stable Reduced vision in both eyes 5 Vincristin, carboplatine Improved vision
18 M 30.3 Right and left prechiasmatic ON, chiasm, right and left radiations Diffuse Stable Reduced vision in right and left eye, visual field defects in both eyes 6
29 M 18.1 Left prechiasmatic ON, chiasm, right and left radiations Mild Stable Blind in left eye, reduced vision and visuals field defect in right eye 6
30 F 15.3 Right and left intraorbital ON, right and, left prechiasmatic ON, chiasm, right and left radiations Diffuse Stable Reduced vision in both eyes, visual field defect in left eye Unknown Vincristin, carboplatine Decreased vision
31 M 48.9 Right and left intraorbital ON, right and left prechiasmatic ON No contrast used Stable Blind in both eyes 1.5
33 F 34.6 Right prechiasmatic ON, chiasm No Stable Reduced vision in right eye 3
35 F 25.4 Right intraorbital ON, right prechiasmatic ON, chiasm, right radiations Mild Stable Blind in right eye, reduced vision and visual field defect in left eye 4
39 F 15.1 Left prechiasmatic ON, chiasm, left radiations No contrast used Stable Blind in left eye, reduced vision and visual field defect in right eye 11 Radiation and surgery Decreased vision
41 F 34.5 Left prechiasmatic ON No Stable Reduced vision in both eyes, visual field defects in both eyes, diffuse hydrocephalus 5
43 M 12.3 Right and left intraorbital ON, right and left prechiasmatic ON, chiasm, right radiations No Stable Reduced vision in right and left eye, visual field defect in right eye, diffuse hydrocephalus 6 Vincristin, carboplatine Stable vision
45 M 46.1 Right intraorbital ON, right prechiasmatic ON, chiasm No Stable Reduced vision in both eyes, visual field defects in both eyes 4
49 M 44.6 Left intraorbital ON Avid Stable Blind in left eye 34 Surgery Decreased vision
50 F 25.3 Right prechiasmatic ON No Stable Reduced vision in right eye Unknown
  1. Abbreviations: ON Optic nerve