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Research
The aim of this study was to determine the economic burden and health-related quality of life (HRQOL) of patients with Spinal Muscular Atrophy (SMA) and their caregivers in Spain.
Orphanet Journal of Rare Diseases 2017 12:141
Published on: 18 August 2017
Position statement
A number of papers have proposed or evaluated the delayed-start design as an alternative to the standard two-arm parallel group randomized clinical trial (RCT) design in the field of rare disease. However the ...
Orphanet Journal of Rare Diseases 2017 12:140
Published on: 17 August 2017
Research
Neurofibromatosis type 1 (NF1) is an autosomal-dominant disease characterised by symptoms of the skin, eyes, nervous system and bones. A previous study indicated that constipation, large rectal diameters and p...
Orphanet Journal of Rare Diseases 2017 12:139
Published on: 16 August 2017
Research
Hypoplastic left heart syndrome (HLHS) covers a spectrum of rare congenital anomalies characterised by a non-apex forming left ventricle and stenosis/atresia of the mitral and aortic valves. Despite many studi...
Orphanet Journal of Rare Diseases 2017 12:138
Published on: 10 August 2017
Position statement
With the Cross-Border Healthcare Directive (2011/24/EU) a mandatory framework was established to foster cooperation on a voluntary basis, within European Reference Networks (ERNs). These networks are composed ...
Orphanet Journal of Rare Diseases 2017 12:137
Published on: 7 August 2017
Research
Ataxia telangiectasia (A-T) is a neurodegenerative disease that leads to mitochondrial dysfunction and oxidative stress. Insulin resistance (IR), type 2 diabetes and the risk for development of cardiovascular ...
Orphanet Journal of Rare Diseases 2017 12:136
Published on: 4 August 2017
Letter to the Editor
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare, autosomal-recessive mitochondrial disorder caused by TYMP mutations presenting with a multisystemic, often lethal syndrome of progressive l...
Orphanet Journal of Rare Diseases 2017 12:135
Published on: 1 August 2017
Letter to the Editor
Angelman syndrome (AS) is a rare neurodevelopmental disorder that is characterised by severe global developmental delays, ataxia, loss of speech, epilepsy, sleep disorders, and a happy disposition. There is cu...
Orphanet Journal of Rare Diseases 2017 12:134
Published on: 1 August 2017
Research
Childhood interstitial lung disease (chILD) represents a rare heterogeneous group of respiratory disorders. In the absence of randomized controlled clinical trials, global collaborations have utilized case ser...
Orphanet Journal of Rare Diseases 2017 12:133
Published on: 25 July 2017
Research
Newborn Screening Connect (NBS Connect) is a web-based self-reported patient registry and resource for individuals and families affected by disorders included in the newborn screening panel. NBS Connect was la...
Orphanet Journal of Rare Diseases 2017 12:132
Published on: 19 July 2017
Research
Lipopolysaccharide-responsive, beige-like anchor protein (LRBA) deficiency is characterized by primary immunodeficiency and autoimmunity. Cancer may present another feature of LRBA deficiency. We describe a ca...
Orphanet Journal of Rare Diseases 2017 12:131
Published on: 18 July 2017
Review
Behçet’s disease (BD) is a systemic vasculitis characterised by a relapsing remitting course, affecting multiple organ systems. In the eye, it is a cause of potentially blinding inflammation in the form of uve...
Orphanet Journal of Rare Diseases 2017 12:130
Published on: 17 July 2017
Research
Autoimmune retinopathy (AIR) is a rare but potentially blinding condition that is often underdiagnosed. Common features in AIR presentation include rapidly progressive vision loss with abnormal electrophysiolo...
Orphanet Journal of Rare Diseases 2017 12:129
Published on: 15 July 2017
Review
Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare oculorenal inflammatory condition that was first described in 1975. In 2001 a major review identified 133 cases in the world literature and pr...
Orphanet Journal of Rare Diseases 2017 12:128
Published on: 14 July 2017
Research
Advances in medical, interventional and surgical treatment have increased average life expectancy of patients with congenital heart defects. As a result a new group of adult patients with congenital cardiac de...
Orphanet Journal of Rare Diseases 2017 12:127
Published on: 12 July 2017
Research
Ataxia Telangiectasia (AT) is a rare incurable genetic disease, caused by biallelic mutations in the Ataxia Telangiectasia-Mutated (ATM) gene. Treatment with glucocorticoid analogues has been shown to improve the...
Orphanet Journal of Rare Diseases 2017 12:126
Published on: 5 July 2017
Research
Mucopolysaccharidosis type I (MPS I) is an autosomal recessive disease due to deficiency of α-L-iduronidase (IDUA), a lysosomal enzyme that degrades glycosaminoglycans (GAG) heparan and dermatan sulfate. To ac...
Orphanet Journal of Rare Diseases 2017 12:125
Published on: 4 July 2017
Review
Spinal muscular atrophy linked to chromosome 5q (SMA) is a recessive, progressive, neuromuscular disorder caused by bi-allelic mutations in the SMN1 gene, resulting in motor neuron degeneration and variable prese...
Orphanet Journal of Rare Diseases 2017 12:124
Published on: 4 July 2017
Research
Fibrodysplasia ossificans progressiva (FOP) is a rare, severely disabling, and life-shortening genetic disorder that causes the formation of heterotopic bone within soft connective tissue. Previous studies fou...
Orphanet Journal of Rare Diseases 2017 12:123
Published on: 30 June 2017
Research
Von Hippel-Lindau (VHL) disease is a rare oncological disease with an incidence of 1:36,000, and is characterized by the growth of different types of tumours. Haemangioblastomas in the central nervous system (...
Orphanet Journal of Rare Diseases 2017 12:122
Published on: 29 June 2017
Research
Wolman disease (WD) is a rare lysosomal storage disorder that is caused by mutations in the LIPA gene encoding lysosomal acid lipase (LAL). Deficiency in LAL function causes accumulation of cholesteryl esters and...
Orphanet Journal of Rare Diseases 2017 12:120
Published on: 28 June 2017
Research
Spinocerebellar ataxia type 29 (SCA29) is an autosomal dominant, non-progressive cerebellar ataxia characterized by infantile-onset hypotonia, gross motor delay and cognitive impairment. Affected individuals e...
Orphanet Journal of Rare Diseases 2017 12:121
Published on: 28 June 2017
Research
PWS is a severe neurodevelopmental genetic disorder now usually diagnosed in the neonatal period from hypotonia and feeding difficulties. Our study analyzed the birth incidence and care of infants with early d...
Orphanet Journal of Rare Diseases 2017 12:118
Published on: 28 June 2017
Research
A localized form of epidermolysis bullosa simplex (EBS-l) is considered one of the mildest forms of epidermolysis bullosa (EB), with blisters limited to the palms and soles. However, these lesions can be very ...
Orphanet Journal of Rare Diseases 2017 12:119
Published on: 28 June 2017
Position statement
Mucopolysaccharidosis type III is a progressive, neurodegenerative lysosomal storage disorder for which there is currently no effective therapy. Though numerous potential therapies are in development, there ar...
Orphanet Journal of Rare Diseases 2017 12:117
Published on: 26 June 2017
