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Cluster headache


Cluster headache (CH) is a primary headache disease characterized by recurrent short-lasting attacks (15 to 180 minutes) of excruciating unilateral periorbital pain accompanied by ipsilateral autonomic signs (lacrimation, nasal congestion, ptosis, miosis, lid edema, redness of the eye). It affects young adults, predominantly males. Prevalence is estimated at 0.5–1.0/1,000. CH has a circannual and circadian periodicity, attacks being clustered (hence the name) in bouts that can occur during specific months of the year. Alcohol is the only dietary trigger of CH, strong odors (mainly solvents and cigarette smoke) and napping may also trigger CH attacks. During bouts, attacks may happen at precise hours, especially during the night. During the attacks, patients tend to be restless. CH may be episodic or chronic, depending on the presence of remission periods. CH is associated with trigeminovascular activation and neuroendocrine and vegetative disturbances, however, the precise cautive mechanisms remain unknown. Involvement of the hypothalamus (a structure regulating endocrine function and sleep-wake rhythms) has been confirmed, explaining, at least in part, the cyclic aspects of CH. The disease is familial in about 10% of cases. Genetic factors play a role in CH susceptibility, and a causative role has been suggested for the hypocretin receptor gene. Diagnosis is clinical. Differential diagnoses include other primary headache diseases such as migraine, paroxysmal hemicrania and SUNCT syndrome. At present, there is no curative treatment. There are efficient treatments to shorten the painful attacks (acute treatments) and to reduce the number of daily attacks (prophylactic treatments). Acute treatment is based on subcutaneous administration of sumatriptan and high-flow oxygen. Verapamil, lithium, methysergide, prednisone, greater occipital nerve blocks and topiramate may be used for prophylaxis. In refractory cases, deep-brain stimulation of the hypothalamus and greater occipital nerve stimulators have been tried in experimental settings. The disease course over a lifetime is unpredictable. Some patients have only one period of attacks, while in others the disease evolves from episodic to chronic form.

Disease name and synonyms

Other terms for cluster headache (CH) are erythroprosopalgia of Bing, ciliary or migrainous neuralgia, erythromelalgia of the head, Horton's headache, histaminic cephalalgia, petrosal neuralgia of Gardner, sphenopalatine, Vidian and Sluder's neuralgia, and hemicrania periodica neuralgiformis. In French, it is named algie vasculaire de la face, somewhat a misnomer since CH does not primarily involve a dysfunction of arteries or veins.

Definition, diagnostic criteria and forms

Cluster headache is a primary headache disease like migraine or tension-type headache. By contrast to secondary headaches, in which the pain is symptomatic of an underlying brain, cranial or systemic disorder, primary headaches are due to spontaneous activation of nociceptive pathways. CH is characterized by recurrent attacks of short-lasting excruciating pain accompanied by signs of autonomic dysfunction, as described in the second version of the International Classification Headaches second edition (ICHD-II) criteria presented in table 1[1]. The patient must have had at least five attacks of severe or very severe unilateral orbital or supraorbital and/or temporal pain, lasting 15 to 180 minutes if untreated. The headache is accompanied by one ipsilateral autonomic symptom among the following: conjunctival injection and lacrimation, nasal congestion or rhinorrhea, forehead and facial sweating, eyelid edema, miosis and ptosis. In the absence of autonomic signs, CH can be diagnosed if a sense of restlessness or agitation is present during the attacks.

Table 1 Diagnostic criteria for cluster headache according to the International Classification of Headache Diseases II

CH is the most common type of the trigeminal autonomic cephalalgias (TACs), which include paroxysmal hemicrania and SUNCT (S hort U nilateral Neuralgiform headache with C onjunctival injection and T earing). It is divided in episodic (3.1.1) and chronic (3.1.2) forms [1], as detailed in table 2. In 80% of cases, the disease is episodic and may present with one or two periods per year, or even may go into remission for many years before development of another cluster period. In about 20% of CH patients the disease is chronic [2]. These patients have ongoing attacks for one year or more, without more than one month of remission. These refractory patients are difficult to diagnose and manage, and need to be referred to a headache specialist.

Table 2 ICHD-II criteria for episodic and chronic cluster headache


The prevalence of CH can be estimated at approximately 0,5 – 1.0/1,000 [312]. Table 3 summarizes the epidemiological studies on CH. Many of these studies are biased by the sample chosen and by the difficulties of diagnosing CH by mailed questionnaires or telephone interviews. In a tertiary care headache clinic, CH was diagnosed in 2.73% of patients. There is a clear male predominance in CH, but it has been estimated to be decreasing over the years [13], maybe due to increased recognition of the disease in women [14]. CH is a condition affecting young adults, first attacks usually occurring in the third decade. It is probably under-diagnosed and unrecognized; a significant diagnostic delay has been reported in most patients [15, 16]. CH in children is rare, but a few cases have been reported [17], the youngest patients being three years old [18]. Symptoms often decrease after age of 70 years. Heavy smoking has been frequently documented amongst CH patients [19].

Table 3 Epidemiological studies of cluster headache

Clinical description: how to recognize cluster headache

Duration and frequency of attacks

Cluster headache attacks are unilateral, severe, short-lasting (15 to 180 minutes) and recurrent (1 every other day to 8 per day) [1]. This special pattern is very important to recognize the cluster headaches and to differentiate them from migraine attacks. A patient describing a pain lasting less than three hours, severe and localized on one side of the head, coming back at specific times of the day or during sleep, must be asked if symptoms like tearing, eye swelling and nasal congestion are present on the other side. The fact that the attack ends after one or two hours must not be attributed to a success of standard analgesics, which are not useful in CH.

Pain description

A prospective study on clinical characteristics of CH has been published by Bahra et al. [2]. Pain is described mostly in the first trigeminal branch territory, on one side of the head only and almost always the same side (rarely, attacks may switch the location). Pain may be centered on the eye but may also be periorbital and temporal, sometimes extending to the maxillary, ear or even occipito-cervical region. Some patients describe the pain as radiating to the teeth, thus they may first consult a dentist. As to its severity, CH is one of the most painful conditions known to man (worse than giving birth according to female patients). It is described as excruciating and intolerable. Patients compare it to a white-hot needle or knife being pushed into the eye, the eye being crushed or ripped of the orbit. Suicidal ideations may be expressed during the attacks. The nickname of the CH among patients is "The Beast", a term suggesting an animal hiding in the shadow, attacking in a terrible and unpredictable way. Pain rises abruptly over a few minutes. It also ends rapidly. In severe chronic forms or in episodic forms with numerous daily attacks, there may be a continuous discomfort on the affected side [20], but usually CH patients are completely asymptomatic between attacks.

Dysautonomic symptoms

Parasympathetic hyperactivity signs include ipsilateral lacrimation, redness of the eye and nasal congestion. The affected side of the face may be red and sweaty. Sympathetic hypoactivity is demonstrated by the combination of ipsilateral ptosis and miosis (droopy eye and smaller pupil on the affected side) during attacks. The combination of ptosis and miosis on one side is called Claude-Bernard-Horner syndrome (CBH). Persistence of CBH signs after the end of the attack in episodic CH should alert the clinician to suspect underlying lesion in hypothalamus, brainstem, paravertebral sympathetic chain or carotid. Proper investigations should be undertaken: brain magnetic resonance imaging (MRI), chest computerized tomography and carotid ultrasound.

Autonomic signs are very prominent in certain patients, but may be subtle or even absent in 3% of patients [21]. They can be unrecognized because of the pain ("I close my eye, I cry because I'm in pain"). In case of uncertainty, the patient can be asked to observe these specific signs during the attack.

Ictal behavior

Physical activity seems to partially alleviate the pain in CH. During the attacks, patients tend to be restless. They may rock from side to side, hit their heads, hit objects with the fist, or even hit their head against the wall [22]. This behavior is so typical of CH that it is accepted as an official criterion in the ICHD-II [1]. Indeed, it is possible to diagnose CH without any dysautonomic sign if the behavioral criterion is satisfied. This restless attitude may help to differentiate CH from migraine, where patients are quiet and avoid any movement. CH patients are cognitively alert, but may also be irritable and aggressive. There is no mental slowing or fatigue, as it may be seen in migraine patients.


CH shows circannual and circadian cyclicity. Peaks have been described around solstices, in relation to changes in daylight duration [23]. Attacks can happen at a precise time during the sleeping cycle, with dramatic regularity reported by patients. This cyclicity is not observed in all CH patients and is not included in the ICHD-II criteria, though most experts find it very suggestive of CH when present.


Alcohol is recognized as the only dietary trigger of CH. Nitroglycerin has been used to trigger attacks for diagnostic purpose (therefore, e nitrates should be avoided during bouts). Strong odors (mainly solvents and cigarette smoke) and napping may trigger CH attacks. It is surprising that all triggers are effective only during bouts. In between periods, patients may smoke and drink alcohol without triggering attacks.

Diagnostic delay

There is a significant delay in diagnosing CH (reported median delay of three years [16]), though there is an improvement as compared to the 1960's when a diagnostic delay of more than 20 years was not infrequent [15]. Up to 30% of patients have previously undergone many investigations and seen dentists, ENT (ears, nose, throat) surgeons, ophthalmologists, even neurologists, without being diagnosed. Up to 16% may have undergone dental, sinus or eye surgery [16]. The periodicity of attacks makes the diagnosis difficult and sometimes suggests an infectious cause. Prednisone can be prescribed for sinusitis and have a positive effect, falsely confirming an erroneous diagnosis. Some patients do not seek medical advice once the bout has ended by itself.

Other features

Though aura is not frequent in CH [24], up to 14% of patients report aura symptoms, with transient visual, motor or sensory disturbances preceding the facial pain [2]. In chronic CH, auras have been reported in 20% of patients [20]. Nausea, vomiting, photophobia and phonophobia can be observed in approximately 50% of patients, and must not discard the diagnosis of CH if other criteria are fulfilled. A shift of the affected side may be observed within a bout or between two bouts in 15% of patients [2]. Case reports of "CH sine headache" have described patients with episodes of unilateral facial autonomic dysfunction without pain [25, 26], but this is very rare.

Etiology: a role for the hypothalamus, but many uncertainties

The exact cause of CH is currently unknown. The first hypotheses on CH, inspired by the effects of vasoactive substances in CH (dilators causing attacks, constrictors ending them) were based on the neurovascular theory. An initial dysfunction or inflammation of the blood vessels in the parasellar or cavernous sinus area would activate the orbital trigeminal pain pathways. Indeed, activation of the trigeminal-vascular system is present, but whether it is a cause or consequence of CH is not clear. It is not specific for CH, since it is also very prominent, and much better demonstrated, in migraine. Later on, the periodicity of CH has oriented studies toward the hypothalamus, with more fruitful results. Positron emission tomography (PET) studies have show an activation of the posterior hypothalamus during CH attacks [27], reinforcing the idea that the hypothalamus may be the CH generator. Voxel-based morphometry studies demonstrated an increase in the gray matter volume of the posterior hypothalamus in CH patients compared to controls [28]. Success of hypothalamic deep-brain stimulation (DBS) [29] and emerging evidence for hypocretin receptor gene involvement also strengthen that hypothesis. Abnormal blood levels of prolactin, testosterone, thyroid stimulating hormone (TSH), and cortisol may be linked to perturbations in the activity of the hypothalamic-pituitary-adrenal axis.

Numerous studies have examined blood levels of other substances in CH patients during attacks, bouts and remissions. Histamine, prostaglandins, opiates, neuropeptids, amines, nitric oxide, monoamine oxydase, serotonin and cytokines values may show significant differences compared to those in non-affected controls. The list is long but, so far, none of these studies allowed a coherent understanding of CH. The parasympathetic activation is thought to be mediated by the trigeminal-autonomic reflex in the brainstem circuitry,via the seventh cranial nerve. The sympathetic innervation pathway to the pupil and eyelid is composed of three neurons and there is no clear demonstration of the site involved and mechanisms underlying the dysfunction in CH. The reason for the male predominance of CH also remains to be clarified.


Initially, CH was not thought to be a genetic disease. With official criteria published and the increasing recognition of the disease, a genetic aspect of CH has been identified. Cases of twin pairs affected by CH have been published [3032]. Studies using large twin registries have shown that monozygotic twins present a higher concordance rate for CH (2/12 pairs) than dizygotic twins (0/25 pairs), indicating the existence of genetic factors, but monozygotic twins can also be concordant or discordant for CH, confirming a role for environmental factors [11, 33]. Family studies of CH patients' cohorts have shown a familial aggregation in 7% to 20% of patients, and a relative risk for first-degree relatives between 14 and 39 [3436]. The transmission mode has still not been established. Some studies have suggested an autosomal dominant way with incomplete penetrance [37], while other described an autosomal recessive transmission [38]. So far, no X-linked pedigrees have been published. No susceptibility locus has been identified. Much work has recently been done on the HCRTR2 gene (hypocretin receptor 2) polymorphism [39, 40], suggesting a role of this gene in CH susceptibility. Hypocretins are secreted in the hypothalamus, a structure clearly involved in CH. All these findings suggest that genetic factors do play a role in CH [41, 42], though, so far, the transmission mode remains to be established and the contribution of individual factors to be clearly understood. The HCRTR2 gene is a promising research area.

Diagnostic methods

Diagnosis of cluster headache is based on clinical criteria and exclusion of a secondary cause. A first attack suggestive of CH must always be thoroughly investigated, and carotid dissection has to be properly excluded either with doppler ultrasound or angio-scanner and magnetic resonance angiography of the neck vessels [43]. When the history is typical with numerous periods, attacks and no interictal abnormalities on neurological examination, MRI is not mandatory. Imaging studies in CH patients are most of the time normal, but lesions can be detected in secondary cases. An association with pituitary tumors has been suspected [44]. Any refractory case should undergo MRI study to exclude a treatable cause. The pituitary, orbit, and trigeminal pathway have to be specifically examined with computed tomography (CT) and MRI.

Differential diagnosis

Primary headache diseases


The only way to differentiate CH from migraine is the clinical history. The questionnaire is of paramount importance. The global picture must be taken into account. In case of doubt, further observation of attacks by the patient is warranted. Migraine and CH are both very incapacitating and share common features, but they also differ on specific points. Migraine is much more frequent than CH (15% of the general population versus 0.05%–0.1%), affects mainly women, and starts earlier in life, often during adolescence or around menarche. Migraine attacks occur at regular intervals over months, without long remission periods, though in some patients seasonal triggers may cause more frequent attacks (allergies, stress). Migraine attacks last longer (more than four hours and can go on for more than 24 hours) [2]. Attacks may have a prodrome with hunger, fatigue, irritability, and start more progressively. Patients tend to stay quiet and avoid any movement. The pain may begin unilaterally but during the attack it may radiate to the whole head. Many patients have attacks on alternate sides. Pain is moderate-to-severe, but is not described as intolerable or excruciating. The presence of nausea and/or photophobia and phonophobia is a main clinical criterium [2], but it is not specific for migraine, as CH can also be accompanied by nausea, photophobia and phonophobia in up to 50% of patients [2]. Unilateral photo- and phonophobia may be more specific of CH and trigeminal autonomic cephalalgias in general [45]. In up to 30% of patients with migraine, autonomic signs like lacrimation and nasal congestion are present. Both CH and migraine can be triggered by alcohol, and relieved by triptans, but CH necessitates parenteral routes of administration. Stress, foods (like chocolate) and menstrual cycle, are not typical triggers for CH. Finally, some cases are difficult to diagnose and should be referred to a headache specialist. In some patients, CH and migraine can coexist, and treatment must be chosen accordingly. Table 4 presents a clinical comparison of CH and migraine.

Table 4 Comparison of migraine and cluster headache

Other trigeminal autonomic cephalalgias (TACs)

Paroxysmal hemicrania (PH) is more frequent in women (80–90%) and differs from CH by the shorter length and higher frequency of attacks [4648]. Absolute response to an adequate dose of indomethacin (150 mg per day or more) confirm the diagnosis of PH [2]. A continuum between paroxysmal hemicrania and CH has been suggested by some authors, due to an overlap in clinical criteria and anecdotal reports of CH patients responding to indomethacin. Indomethacin treatment in any refractory case of CH, or cases with frequent and shorter attacks, has been suggested by Matharu and Goatsby [49].

SUNCT syndrome is a very rare entity [50]. Its prevalence is estimated around 6,6 per 100,000 [51]. Attacks are very short and occur up to 300 times a day.

Hemicrania continua may be confused with chronic cluster headache, and if there is a doubt, a trial with indomethacin should be made, HC being highly responsive to this drug [52, 53]. Table 5 presents the main characteristics of TACs.

Table 5 Trigeminal-autonomic cephalalgias (TACs)

Other ICHD-II categories

Trigeminal neuralgia (TN) and CH both involve paroxysms of unilateral and severe pain, but specific traits are found on the questionnaire [2]. TN is more frequent in women in their fifties or older. Attacks are centered on maxillary and/or mandibular area, they are more frequent, briefer, electric-like and are triggered by touching specific zones of the face or buccal cavity. Eating, laughing, talking, shaving or brushing the teeth may all trigger the shocks. Patients may loose weight because they avoid eating. There is no clustering in periods, and mostly the pain goes on until the treatment starts. TN responds very well to carbamazepine. Both diseases may occur in the same patient as cluster-tic (tic standing for tic douloureux, a French term). Table 6 summarizes the clinical manifestations helping to distinguish TN from CH.

Table 6 Comparison of cluster headache and trigeminal neuralgia

In an elderly patient with exclusively nocturnal attacks, hypnic headache may be diagnosed, but it is very rare and pain is usually bilateral, diffuse and without autonomic signs. Attacks occur exclusively during sleep [54].

In doubt, the clinician may ask the patient to complete a diary of the attacks, to precise their duration, autonomic symptoms, triggers, response to treatment, and daily cyclicity. The importance of history taking in headache medicine cannot be overemphasized.

Causes of symptomatic CH

Features suggesting a secondary CH are: persistent or worsening pain, abnormal signs on neurological examination, and a first period after 50 years old. An underlying cause has sometimes been found in a patient with typical CH features [55, 56]. Benign intracranial tumors like meningiomas and neurinomas, but also carcinomas and metastases, have been reported. There seems to be an overrepresentation of pituitary tumors in CH patients [44], and a role of prolactin has been suggested in these cases. Orbital tumors or infections have been reported. Sinusitis may present with symptoms typical for CH. Arteriovenous malformations and aneurysms, if strategically located, may cause CH symptoms. In a first episode, carotid dissection has to be suspected and ruled out (it also can produce Claude-Bernard-Horner syndrome, and the pain may respond to triptans) [57]. Any case of refractory CH deserves a brain MRI. Some experts even recommend MRI for every CH patient, to avoid unnecessary treatments if a treatable cause is found.

Genetic counseling

As familial cluster headache is rare, thus, considering the limited knowledge on the genes involved and the transmission mode, genetic counseling is not routinely part of the CH management. Familial cases should be identified and, if possible, the family referred to a specialist in cluster headache. There is no known preventive treatment for CH, or curative intervention, but affected patients may inform their families of the CH symptoms, thus any delay in diagnosis among relatives to be avoided. Antenatal diagnosis is not applicable


Acute treatments are efficient to alleviate pain during attacks. Prophylactic treatments aim at reducing the daily number of attacks. No curative treatment for CH is currently available. Guidelines (evidence-based recommendations and good practice points) for the treatment of CH are developed by the European Federation of Neurological Societies (EFNS) [58].

Acute management of attacks

Because of the excruciating character of the pain, rapid-acting treatments are preferred for acute management of attacks [59]. The oral route of administration is too slow and is rarely used. Inhaled, subcutaneous and intra-nasal treatments are preferred. The pain in CH is often underestimated by the medical community. Interictally, patients appear normal. In most cases, witnessing a CH attack is convincing enough, but not possible for every practitioner. Adequate treatments must be provided, and a nihilistic, observational approach should be absolutely avoided.

The two most efficient acute treatments are subcutaneous sumatriptan and high-flow inhaled oxygen.

Sumatriptan is a serotonin 5HT1 B/D agonist, acting on blood vessels with a vasoconstricting effect, and centrally on brainstem receptors. Subcutaneous sumatriptan 6 mg (Imiject, Imitrex) has been shown to efficiently relieve the CH pain and dramatically improve the management of patients [60]. After the injection, the patient may feel a rush of heat and chest tightness that disappear in a few minutes and are followed by rapid relief of the pain. Intra-nasal sumatriptan [61, 62] and zolmitriptan [63] may be tried if patients refuse to use injections. Absolute contra-indications to subcutaneous sumatriptan include pregnancy, lactation, coronary artery disease, stroke, and peripheral artery disease. Relative contra-indications are age (under 18 or over 65), an isolated controlled vascular risk factor, Raynaud phenomenon, allergy to sulfa medications, treatment with a serotonin recapture inhibitor (SSRI). Maximal doses for 24 h period (sumatriptan 12 mg subcutaneous or 40 mg intra-nasal, zolmitriptan 10 mg intra-nasal) have to be explained to the patient to avoid dangerous side effects, such as coronary or distal artery spasm. Surprisingly, CH patients do not develop medication-overuse headache (MOH) with triptans as often as migrainers do [64]. They may use regular sumatriptan for many months without developing a different type of headache. As MOH is more frequent in CH patients with a history/diagnosis of migraine, these patients must be carefully monitored for MOH, especially if CH is chronic and refractory [65].

Inhaled oxygen with high-flow (10 to 15 l per minute) 100% normobaric oxygen breathed through a mask is efficient and useful especially when contra-indications to triptans exist [66, 67]. The device is not easy to carry around, and not always reimbursed by health security services, depending on the country. The efficacy of oxygen has been recently re-examined and confirmed. There are no contra-indications or limitations for the use of oxygen.

Ergotamine and dihydroergotamine have been used in CH [68]. They must not be combined with triptans on the same 24 hour period, have the same contra-indications as triptans (without additional efficacy), therefore are rarely useful.

Intra-nasal application of topical lidocaine may be tried in refractory CH cases or in case of contra-indications to triptans. Its efficacy is not well proven.

Topic cocaine was used in the past, but abandoned because of equivocal efficacy, side-effects and risks of dependency.

Prophylactic treatment

The aim of prophylactic treatment is to reduce the frequency of attacks during the bout. Continuous use of prophylactic treatments in episodic CH is not recommended, since there is no proof that it prevents the next bout. Therefore, the dose may be progressively decreased after two or three months, or after the usual known duration of the bout. The prophylactic treatment should be restarted if attacks reappear. In patients with few attacks per week responding to acute treatment, prophylactic treatment can be withheld. In chronic CH, treatments are used for a long term epriod, and a low attack rate has to be reached (always considering the potentially serious and incapacitating side effects).

The calcium-channel blocker verapamil remains the main treatment of episodic and chronic CH [69, 70]. Doses range from 360 mg to 960 mg per day, and the maximal tolerated dose should be reached before concluding about efficacy. Side effects are weakness, fatigue, lower extremities edema, and conduction heart block. An electrocardiogram should be performed at the baseline and for every increase in the dose when it exceeds 480 mg per day [71].

Greater occipital nerve blocks are used, based on the connection between this nerve and the trigeminal circuitry [72]. One randomized study showed that this technique may end a bout, or, at least, may diminish the number of attacks per day [73]. More evidence is needed to recommend this procedure [74], but it is widely used by experts [75, 76]. The block is performed with a long-acting injectable steroid, sometimes combined with a local anesthetic. Different combinations have been described. The needle is inserted midway between the mastoid and the occipital protuberance, until it touches the occipital bone (sub occipital technique).

Topiramate has shown a convincing efficacy in CH [77, 78]. Usual dosing is 100 mg per day (range 25 mg to 200 mg). Side effects include numbness and tingling in the extremities, weight loss, and neuro-cognitive difficulties, all reversible after drug discontinuation.

Lithium is used in chronic CH [69, 79, 80]. Doses range from 600 to 1200 mg per day. Blood levels must not exceed 0,9 mEq per liter, and thyroid and renal function must be monitored. Side effects include tremors, insomnia, fatigue, nausea and blurred vision. Intoxication may be severe and has to be suspected quickly if nausea, confusion, rigidity and difficulty to walk appear. Because of these side effects, lithium is used sparingly, in selected cases only.

A short course of decreasing-dose prednisone (starting at 1 mg/kg) may be used to treat a bout refractory to verapamil (however, recurrence is frequent with the decrease of the dose). Long-term side effects of corticotherapy restrict the use of prednisone in chronic CH.

Methysergide acts on serotonin receptors. Doses range from 6 to 12 mg per day. Some patients do respond very well to this drug but a major limitation is that triptans and ergots cannot be used simultaneously because of the risk of serotoninergic syndrome. The main side effect is nausea, sometimes severe. Methysergide can be considered if oxygen alone is used as an acute treatment. The main complication is retroperitoneal, pulmonary or cardiac fibrosis after prolonged use. This mandates one-month drug-holiday after six months of use, then methysergide can be started again. Methysergide is not available in United States.

Valproic acid [81], pizotifen, gabapentin [82, 83], baclofen [84], and melatonin [85, 86] have shown some effect in CH prophylaxis and may be used in selected patients as a second-line therapy.

Surgical approaches

Destructive approaches like trigeminal section, thermocoagulation of gasserian ganglion, glycerol rhizotomy [87, 88] and radiosurgery [8992] of the trigeminal nerve have shown variable results and irreversible complications like anesthesia dolorosa.

Hypothalamic deep-brain stimulation (hDBS) has shown a convincing benefit in some refractory patients in series totalizing a few dozens of cases [9396], but can be completely inefficient[97], and has potential serious complications. Its mechanism is not well understood[98] and no controlled studies are available.

Neurostimulation of the greater occipital nerve has recently been described [76, 99101]. It is less invasive than DBS but costly; its long-term effects are unknown.

Non-pharmacological approaches like massotherapy, physiotherapy and acupuncture have not been adequately studied in CH.


CH has a very unpredictable course. Some patients have only one period of attacks, while in others the disease evolves from episodic to chronic form. There are no known factors for chronicization of the CH. Total remission of the disease has been described. With aging, attacks often decrease and active CH is rarely seen after age of 75 years.


CH is a primary trigeminal-autonomic cephalalgia responsible for recurrent unilateral short-lasting attacks of excruciating orbitotemporal pain. The cause of cluster headache is not known and there is no unifying hypothesis to explain all the clinical particularities of this disease. About 10% of CH patients have a familial form and the existence of genetic factors has been confirmed. The hypocretin receptor gene may be involved, but implication of other genes can't be excluded. In the absence of any radiological or biological marker, diagnosis relies upon clinical history. Patients are often misdiagnosed as having secondary headaches due to sinus, dental or eye disorders or as having migraine, leading to inadequate management. No curative treatment currently exists, however efficient treatment do exist to shorten painful attacks (acute treatments) and to reduce the number of daily attacks (prophylactic treatments). Ongoing research is very active. Deep-brain stimulation and occipital nerve stimulators are promising options for refractory patients but are used currently in an experimental setting. The current pathophysiological focus is on the hypothalamus. The combination of imaging techniques and genetic studies may help us to better understand this terrible and fascinating condition, ultimately leading to improvement of the care and quality of life of these patients.



cluster headache


International Classification Headaches second edition


trigeminal-autonomic cephalalgia


Short Unilateral Neuralgiform headache with Conjunctival injection and Tearing


Claude-Bernard-Horner syndrome

HCRTR2 gene:

hypocretin receptor 2 gene


magnetic resonance imaging


ears, nose, throat


positron emission tomography


hypothalamic deep-brain stimulation


thyroid stimulating hormone


paroxysmal hemicrania


European Federation of Neurological Societies


serotonin recapture inhibitor


medication-overuse headache.


  1. The International Classification of Headache Disorders. Cephalalgia. 2004, 24 (Suppl 1): 9-160. 2

  2. Bahra A, May A, Goadsby PJ: Cluster headache: a prospective clinical study with diagnostic implications. Neurology. 2002, 58: 354-361.

    Article  PubMed  Google Scholar 

  3. D'Alessandro R, Gamberini G, Benassi G, Morganti G, Cortelli P, Lugaresi E: Cluster headache in the Republic of San Marino. Cephalalgia. 1986, 6: 159-162. 10.1046/j.1468-2982.1986.0603159.x.

    Article  PubMed  Google Scholar 

  4. Katsarava Z, Obermann M, Yoon MS, Dommes P, Kuznetsova J, Weimar C, Diener HC: Prevalence of cluster headache in a population-based sample in Germany. Cephalalgia. 2007, 27: 1014-1019. 10.1111/j.1468-2982.2007.01380.x. Epub 2007 Jul 1030

    Article  CAS  PubMed  Google Scholar 

  5. Sjaastad O, Bakketeig LS: Cluster headache prevalence. Vaga study of headache epidemiology. Cephalalgia. 2003, 23: 528-533. 10.1046/j.1468-2982.2003.00585.x.

    Article  CAS  PubMed  Google Scholar 

  6. Swanson JW, Yanagihara T, Stang PE, O'Fallon WM, Beard CM, Melton LJ, Guess HA: Incidence of cluster headaches: a population-based study in Olmsted County, Minnesota. Neurology. 1994, 44: 433-437.

    Article  CAS  PubMed  Google Scholar 

  7. Tonon C, Guttmann S, Volpini M, Naccarato S, Cortelli P, D'Alessandro R: Prevalence and incidence of cluster headache in the Republic of San Marino. Neurology. 2002, 58: 1407-1409.

    Article  CAS  PubMed  Google Scholar 

  8. Torelli P, Beghi E, Manzoni GC: Cluster headache prevalence in the Italian general population. Neurology. 2005, 64: 469-474.

    Article  PubMed  Google Scholar 

  9. Torelli P, Castellini P, Cucurachi L, Devetak M, Lambru G, Manzoni GC: Cluster headache prevalence: methodological considerations. A review of the literature. Acta Biomed. 2006, 77: 4-9.

    PubMed  Google Scholar 

  10. Ekbom K, Ahlborg B, Schele R: Prevalence of migraine and cluster headache in Swedish men of 18. Headache. 1978, 18: 9-19. 10.1111/j.1526-4610.1978.hed1801009.x.

    Article  CAS  PubMed  Google Scholar 

  11. Ekbom K, Svensson DA, Pedersen NL, Waldenlind E: Lifetime prevalence and concordance risk of cluster headache in the Swedish twin population. Neurology. 2006, 67: 798-803. 10.1212/01.wnl.0000233786.72356.3e.

    Article  PubMed  Google Scholar 

  12. Evers S, Fischera M, May A, Berger K: Prevalence of cluster headache in Germany: results of the epidemiological DMKG study. J Neurol Neurosurg Psychiatry. 2007, 78: 1289-1290. 10.1136/jnnp.2007.124206.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Manzoni GC: Male preponderance of cluster headache is progressively decreasing over the years. Headache. 1997, 37: 588-589. 10.1046/j.1526-4610.1997.3709588.x.

    Article  CAS  PubMed  Google Scholar 

  14. Broner SW, Sun-Edelstein C, Lay CL: Cluster headache in women. Curr Pain Headache Rep. 2007, 11: 127-130. 10.1007/s11916-007-0009-7.

    Article  PubMed  Google Scholar 

  15. Bahra A, Goadsby PJ: Diagnostic delays and mis-management in cluster headache. Acta Neurol Scand. 2004, 109: 175-179. 10.1046/j.1600-0404.2003.00237.x.

    Article  CAS  PubMed  Google Scholar 

  16. van Vliet JA, Eekers PJ, Haan J, Ferrari MD: Features involved in the diagnostic delay of cluster headache. J Neurol Neurosurg Psychiatry. 2003, 74: 1123-1125. 10.1136/jnnp.74.8.1123.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  17. Lampl C: Childhood-onset cluster headache. Pediatr Neurol. 2002, 27: 138-140. 10.1016/S0887-8994(02)00406-X.

    Article  PubMed  Google Scholar 

  18. Garrido C, Tuna A, Ramos S, Temudo T: [Cluster headache in a 3 year old child]. Rev Neurol. 2001, 33: 732-735.

    CAS  PubMed  Google Scholar 

  19. Cirillo M, Stellato D, Lombardi C, De Santo NG, Covelli V: Headache and cardiovascular risk factors: positive association with hypertension. Headache. 1999, 39: 409-416. 10.1046/j.1526-4610.1999.3906409.x.

    Article  CAS  PubMed  Google Scholar 

  20. Donnet A, Lanteri-Minet M, Guegan-Massardier E, Mick G, Fabre N, Geraud G, Lucas C, Navez M, Valade D: Chronic cluster headache: a French clinical descriptive study. J Neurol Neurosurg Psychiatry. 2007, 78: 1354-1358. 10.1136/jnnp.2006.112037. Epub 2007 Apr 1318

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  21. Ekbom K: Evaluation of clinical criteria for cluster headache with special reference to the classification of the International Headache Society. Cephalalgia. 1990, 10: 195-197. 10.1046/j.1468-2982.1990.1004195.x.

    Article  CAS  PubMed  Google Scholar 

  22. Torelli P, Manzoni GC: Pain and behaviour in cluster headache. A prospective study and review of the literature. Funct Neurol. 2003, 18: 205-210.

    PubMed  Google Scholar 

  23. Kudrow L: The cyclic relationship of natural illumination to cluster period frequency. Cephalalgia. 1987, 7 (Suppl 6): 76-78.

    PubMed  Google Scholar 

  24. Ekbom K: A clinical comparison of cluster headache and migraine. Acta Neurol Scand. 1970, 1+-Suppl 41

  25. Russell MB: Cluster headache sine headache: two new cases in one family. Cephalalgia. 2002, 22: 1-10.1046/j.1468-2982.2002.00321.x.

    Article  CAS  PubMed  Google Scholar 

  26. Salvesen R: Cluster headache sine headache: case report. Neurology. 2000, 55: 451-

    Article  CAS  PubMed  Google Scholar 

  27. May A, Bahra A, Buchel C, Frackowiak RS, Goadsby PJ: Hypothalamic activation in cluster headache attacks. Lancet. 1998, 352: 275-278. 10.1016/S0140-6736(98)02470-2.

    Article  CAS  PubMed  Google Scholar 

  28. May A, Ashburner J, Buchel C, McGonigle DJ, Friston KJ, Frackowiak RS, Goadsby PJ: Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med. 1999, 5: 836-838. 10.1038/10561.

    Article  CAS  PubMed  Google Scholar 

  29. Leone M, Franzini A, Bussone G: Stereotactic stimulation of posterior hypothalamic gray matter in a patient with intractable cluster headache. N Engl J Med. 2001, 1428-1429. 10.1056/NEJM200111083451915.

    Google Scholar 

  30. Couturier EG, Hering R, Steiner TJ: The first report of cluster headache in identical twins. Neurology. 1991, 41: 761-

    Article  CAS  PubMed  Google Scholar 

  31. Roberge C, Bouchard JP, Simard D, Gagne R: Cluster headache in twins. Neurology. 1992, 42: 1255-1256.

    Article  CAS  PubMed  Google Scholar 

  32. Sjaastad O, Shen JM, Stovner LJ, Elsas T: Cluster headache in identical twins. Headache. 1993, 33: 214-217. 10.1111/j.1526-4610.1993.hed33040214.x.

    Article  CAS  PubMed  Google Scholar 

  33. Svensson D, Ekbom K, Pedersen NL, Traff H, Waldenlind E: A note on cluster headache in a population-based twin register. Cephalalgia. 2003, 23: 376-380. 10.1046/j.1468-2982.2003.00521.x.

    Article  PubMed  Google Scholar 

  34. El Amrani M, Ducros A, Boulan P, Aidi S, Crassard I, Visy JM, Tournier-Lasserve E, Bousser MG: Familial cluster headache: a series of 186 index patients. Headache. 2002, 42: 974-977. 10.1046/j.1526-4610.2002.02226.x.

    Article  PubMed  Google Scholar 

  35. Leone M, Russell MB, Rigamonti A, Attanasio A, Grazzi L, D'Amico D, Usai S, Bussone G: Increased familial risk of cluster headache. Neurology. 2001, 56: 1233-1236.

    Article  CAS  PubMed  Google Scholar 

  36. Torelli P, Manzoni GC: Clinical observations on familial cluster headache. Neurol Sci. 2003, 24: 61-64.

    CAS  PubMed  Google Scholar 

  37. Russell MB, Andersson PG, Thomsen LL, Iselius L: Cluster headache is an autosomal dominantly inherited disorder in some families: a complex segregation analysis. J Med Genet. 1995, 32: 954-956.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  38. De Simone R, Fiorillo C, Bonuso S, Castaldo G: A cluster headache family with possible autosomal recessive inheritance. Neurology. 2003, 61: 578-579.

    Article  PubMed  Google Scholar 

  39. Rainero I, Rubino E, Valfre W, Gallone S, De Martino P, Zampella E, Pinessi L: Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis. J Headache Pain. 2007, 8: 152-156. 10.1007/s10194-007-0383-x. Epub 2007 Jun 2011

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  40. Rainero I, Gallone S, Rubino E, Ponzo P, Valfre W, Binello E, Fenoglio P, Gentile S, Anoaica M, Gasparini M, Pinessi L: Haplotype Analysis Confirms the Association Between the HCRTR2 Gene and Cluster Headache. Headache. 2008, 48: 1108-14. 10.1111/j.1526-4610.2008.01080.x.

    Article  PubMed  Google Scholar 

  41. Pinessi L, Rainero I, Rivoiro C, Rubino E, Gallone S: Genetics of cluster headache: an update. J Headache Pain. 2005, 6: 234-236. 10.1007/s10194-005-0194-x.

    Article  PubMed Central  PubMed  Google Scholar 

  42. Russell MB: Genetics in primary headaches. J Headache Pain. 2007, 8: 190-195. 10.1007/s10194-007-0389-4. Epub 2007 Jun 2011

    Article  PubMed Central  PubMed  Google Scholar 

  43. Rigamonti A, Iurlaro S, Reganati P, Zilioli A, Agostoni E: Cluster headache and internal carotid artery dissection: two cases and review of the literature. Headache. 2008, 48: 467-470. 10.1111/j.1526-4610.2007.01034.x.

    Article  PubMed  Google Scholar 

  44. Levy MJ, Matharu MS, Meeran K, Powell M, Goadsby PJ: The clinical characteristics of headache in patients with pituitary tumours. Brain. 2005, 128: 1921-1930. 10.1093/brain/awh525. Epub 2005 May 1911

    Article  CAS  PubMed  Google Scholar 

  45. Irimia P, Cittadini E, Paemeleire K, Cohen AS, Goadsby PJ: Unilateral photophobia or phonophobia in migraine compared with trigeminal autonomic cephalalgias. Cephalalgia. 2008, 28: 626-630. 10.1111/j.1468-2982.2008.01565.x.

    Article  CAS  PubMed  Google Scholar 

  46. Boes C: Differentiating paroxysmal hemicrania from cluster headache. Cephalalgia. 2005, 25: 241-243. 10.1111/j.1468-2982.2004.00925.x.

    Article  CAS  PubMed  Google Scholar 

  47. Goadsby P, Lipton R: A review of paroxysmal hemicranias, SUNCT syndrome, and other short lasting headaches with autonomic features, including new cases. Brain. 1997, 193-209. 10.1093/brain/120.1.193.

    Google Scholar 

  48. Goadsby PJ: Trigeminal autonomic cephalalgias. Pathophysiology and classification. Rev Neurol (Paris). 2005, 161: 692-695.

    Article  CAS  Google Scholar 

  49. Matharu MS, Goadsby PJ: Trigeminal autonomic cephalgias. J Neurol Neurosurg Psychiatry. 2002, 72 (Suppl 2): ii19-ii26.

    PubMed Central  PubMed  Google Scholar 

  50. Cohen AS, Matharu MS, Goadsby PJ: Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) or cranial autonomic features (SUNA) – a prospective clinical study of SUNCT and SUNA. Brain. 2006, 129: 2746-2760. 10.1093/brain/awl202.

    Article  PubMed  Google Scholar 

  51. Williams MH, Broadley SA: SUNCT and SUNA: clinical features and medical treatment. J Clin Neurosci. 2008, 15: 526-534. 10.1016/j.jocn.2006.09.006.

    Article  PubMed  Google Scholar 

  52. Rapoport AM, Bigal ME: Hemicrania continua: clinical and nosographic update. Neurol Sci. 2003, 24 (Suppl 2): S118-121.

    PubMed  Google Scholar 

  53. Silberstein SD, Peres MF: Hemicrania continua. Arch Neurol. 2002, 59: 1029-1030. 10.1001/archneur.59.6.1029.

    Article  PubMed  Google Scholar 

  54. De Simone R, Marano E, Ranieri A, Bonavita V: Hypnic headache: an update. Neurol Sci. 2006, 27 (Suppl 2): S144-148. 10.1007/s10072-006-0590-2.

    Article  PubMed  Google Scholar 

  55. Carter DM: Cluster headache mimics. Curr Pain Headache Rep. 2004, 8: 133-139. 10.1007/s11916-004-0027-7.

    Article  PubMed  Google Scholar 

  56. Favier I, van Vliet JA, Roon KI, Witteveen RJ, Verschuuren JJ, Ferrari MD, Haan J: Trigeminal autonomic cephalgias due to structural lesions: a review of 31 cases. Arch Neurol. 2007, 64: 25-31. 10.1001/archneur.64.1.25.

    Article  PubMed  Google Scholar 

  57. Leira EC, Cruz-Flores S, Leacock RO, Abdulrauf SI: Sumatriptan can alleviate headaches due to carotid artery dissection. Headache. 2001, 41: 590-591. 10.1046/j.1526-4610.2001.041006590.x.

    Article  CAS  PubMed  Google Scholar 

  58. May A, Leone M, Afra J, Linde M, Sandor PS, Evers S, Goadsby PJ: EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias. Eur J Neurol. 2006, 13: 1066-1077. 10.1111/j.1468-1331.2006.01566.x.

    Article  CAS  PubMed  Google Scholar 

  59. Cohen AS, Matharu MS, Goadsby PJ: Trigeminal autonomic cephalalgias: current and future treatments. Headache. 2007, 47: 969-980. 10.1111/j.1526-4610.2007.00839.x.

    Article  PubMed  Google Scholar 

  60. Treatment of acute cluster headache with sumatriptan. The Sumatriptan Cluster Headache Study Group. N Engl J Med. 1991, 322-326.

  61. Schuh-Hofer S, Reuter U, Kinze S, Einhaupl K, Arnold G: Treatment of acute cluster headache with 20 mg sumatriptan nasal spray – an open pilot study. J Neurol. 2002, 94-99. 10.1007/PL00007854.

    Google Scholar 

  62. van Vliet JA, Bahra A, Martin V, Ramadan N, Aurora SK, Mathew NT, Ferrari MD, Goadsby PJ: Intranasal sumatriptan in cluster headache: randomized placebo-controlled double-blind study. Neurology. 2003, 60: 630-633. 10.1001/archneur.60.4.630.

    Article  CAS  PubMed  Google Scholar 

  63. Rapoport AM, Mathew NT, Silberstein SD, Dodick D, Tepper SJ, Sheftell FD, Bigal ME: Zolmitriptan nasal spray in the acute treatment of cluster headache: a double-blind study. Neurology. 2007, 69: 821-826. 10.1212/01.wnl.0000267886.85210.37.

    Article  CAS  PubMed  Google Scholar 

  64. Centonze V, Bassi A, Causarano V, Dalfino L, Cassiano MA, Centonze A, Fabbri L, Albano O: Sumatriptan overuse in episodic cluster headache: lack of adverse events, rebound syndromes, drug dependence and tachyphylaxis. Funct Neurol. 2000, 15: 167-170.

    CAS  PubMed  Google Scholar 

  65. Paemeleire K, Evers S, Goadsby PJ: Medication-overuse headache in patients with cluster headache. Curr Pain Headache Rep. 2008, 12: 122-127. 10.1007/s11916-008-0023-4.

    Article  PubMed  Google Scholar 

  66. Fogan L: Treatment of cluster headache. A double-blind comparison of oxygen v air inhalation. Arch Neurol. 1985, 362-363.

    Google Scholar 

  67. Kudrow L: Response of cluster headache attacks to oxygen inhalation. Headache. 1981, 1-4. 10.1111/j.1526-4610.1981.hed2101001.x.

    Google Scholar 

  68. Ekbom K, Paalzow L, Waldenlind E: Low biological availability of ergotamine tartrate after oral dosing in cluster headache. Cephalalgia. 1981, 1: 203-207. 10.1046/j.1468-2982.1981.0104203.x.

    Article  CAS  PubMed  Google Scholar 

  69. Bussone G, Leone M, Peccarisi C, Micieli G, Granella F, Magri M, Manzoni GC, Nappi G: Double blind comparison of lithium and verapamil in cluster headache prophylaxis. Headache. 1990, 30: 411-417. 10.1111/j.1526-4610.1990.hed3007411.x.

    Article  CAS  PubMed  Google Scholar 

  70. Leone M, D'Amico D, Frediani F, Moschiano F, Grazzi L, Attanasio A, Bussone G: Verapamil in the prophylaxis of episodic cluster headache: a double-blind study versus placebo. Neurology. 2000, 1382-1385.

    Google Scholar 

  71. Cohen AS, Matharu MS, Goadsby PJ: Electrocardiographic abnormalities in patients with cluster headache on verapamil therapy. Neurology. 2007, 69: 668-675. 10.1212/01.wnl.0000267319.18123.d3.

    Article  CAS  PubMed  Google Scholar 

  72. Bartsch T, Goadsby PJ: Increased responses in trigeminocervical nociceptive neurons to cervical input after stimulation of the dura mater. Brain. 2003, 126: 1801-1813. 10.1093/brain/awg190. Epub 2003 Jun 1823

    Article  CAS  PubMed  Google Scholar 

  73. Ambrosini A, Vandenheede M, Rossi P, Aloj F, Sauli E, Pierelli F, Schoenen J: Suboccipital injection with a mixture of rapid- and long-acting steroids in cluster headache: a double-blind placebo-controlled study. Pain. 2005, 118: 92-96. 10.1016/j.pain.2005.07.015. Epub 2005 Oct 2003

    Article  CAS  PubMed  Google Scholar 

  74. Ashkenazi A, Levin M: Greater occipital nerve block for migraine and other headaches: is it useful?. Curr Pain Headache Rep. 2007, 11: 231-235. 10.1007/s11916-007-0195-3.

    Article  PubMed  Google Scholar 

  75. Afridi SK, Shields KG, Bhola R, Goadsby PJ: Greater occipital nerve injection in primary headache syndromes – prolonged effects from a single injection. Pain. 2006, 122: 126-129. 10.1016/j.pain.2006.01.016. Epub 2006 Mar 2009

    Article  CAS  PubMed  Google Scholar 

  76. Busch V, Jakob W, Juergens T, Schulte-Mattler W, Kaube H, May A: Occipital nerve blockade in chronic cluster headache patients and functional connectivity between trigeminal and occipital nerves. Cephalalgia. 2007, 27: 1206-1214. 10.1111/j.1468-2982.2007.01424.x. Epub 2007 Sep 1210

    Article  CAS  PubMed  Google Scholar 

  77. Leone M, Dodick D, Rigamonti A, D'Amico D, Grazzi L, Mea E, Bussone G: Topiramate in cluster headache prophylaxis: an open trial. Cephalalgia. 2003, 23: 1001-1002. 10.1046/j.1468-2982.2003.00665.x.

    Article  CAS  PubMed  Google Scholar 

  78. McGeeney BE: Topiramate in the treatment of cluster headache. Curr Pain Headache Rep. 2003, 7: 135-138. 10.1007/s11916-003-0023-3.

    Article  PubMed  Google Scholar 

  79. Reilly D: Lithium vs placebo in cluster headache. Cephalalgia. 1998, 18: 1-10.1046/j.1468-2982.1998.1801001.x.

    Article  CAS  PubMed  Google Scholar 

  80. Steiner T, Hering R, Couturier E, Davies P, Whitmarsh T: Double-blind placebo-controlled trial of lithium in episodic cluster headache. Cephalalgia. 1997, 673-675. 10.1046/j.1468-2982.1997.1706673.x.

    Google Scholar 

  81. Pascual J, Lainez MJ, Dodick D, Hering-Hanit R: Antiepileptic drugs for the treatment of chronic and episodic cluster headache: a review. Headache. 2007, 47: 81-89.

    PubMed  Google Scholar 

  82. Leandri M, Luzzani M, Cruccu G, Gottlieb A: Drug-resistant cluster headache responding to gabapentin: a pilot study. Cephalalgia. 2001, 21: 744-746. 10.1046/j.1468-2982.2001.00260.x.

    Article  CAS  PubMed  Google Scholar 

  83. Schuh-Hofer S, Israel H, Neeb L, Reuter U, Arnold G: The use of gabapentin in chronic cluster headache patients refractory to first-line therapy. Eur J Neurol. 2007, 14: 694-696. 10.1111/j.1468-1331.2007.01738.x.

    Article  CAS  PubMed  Google Scholar 

  84. Hering-Hanit R, Gadoth N: The use of baclofen in cluster headache. Curr Pain Headache Rep. 2001, 5: 79-82. 10.1007/s11916-001-0014-1.

    Article  CAS  PubMed  Google Scholar 

  85. Leone M, D'Amico D, Moschiano F, Fraschini F, Bussone G: Melatonin versus placebo in the prophylaxis of cluster headache: a double-blind pilot study with parallel groups. Cephalalgia. 1996, 16: 494-496. 10.1046/j.1468-2982.1996.1607494.x.

    Article  CAS  PubMed  Google Scholar 

  86. Pringsheim T, Magnoux E, Dobson CF, Hamel E, Aube M: Melatonin as adjunctive therapy in the prophylaxis of cluster headache: a pilot study. Headache. 2002, 42: 787-792. 10.1046/j.1526-4610.2002.02181.x.

    Article  PubMed  Google Scholar 

  87. Hassenbusch SJ, Kunkel RS, Kosmorsky GS, Covington EC, Pillay PK: Trigeminal cisternal injection of glycerol for treatment of chronic intractable cluster headaches. Neurosurgery. 1991, 29: 504-508. 10.1097/00006123-199110000-00003.

    Article  CAS  PubMed  Google Scholar 

  88. Pieper DR, Dickerson J, Hassenbusch SJ: Percutaneous retrogasserian glycerol rhizolysis for treatment of chronic intractable cluster headaches: long-term results. Neurosurgery. 2000, 46: 363-368. 10.1097/00006123-200002000-00020. discussion 368–370

    Article  CAS  PubMed  Google Scholar 

  89. Donnet A, Tamura M, Valade D, Regis J: Trigeminal nerve radiosurgical treatment in intractable chronic cluster headache: unexpected high toxicity. Neurosurgery. 2006, 59: 1252-1257. 10.1227/01.NEU.0000245612.86484.7. discussion 1257

    Article  PubMed  Google Scholar 

  90. Donnet A, Valade D, Regis J: Gamma knife treatment for refractory cluster headache: prospective open trial. J Neurol Neurosurg Psychiatry. 2005, 76: 218-221. 10.1136/jnnp.2004.041202.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  91. McClelland S, Barnett GH, Neyman G, Suh JH: Repeat trigeminal nerve radiosurgery for refractory cluster headache fails to provide long-term pain relief. Headache. 2007, 47: 298-300. 10.1111/j.1526-4610.2006.00701.x.

    Article  PubMed  Google Scholar 

  92. McClelland S, Tendulkar RD, Barnett GH, Neyman G, Suh JH: Long-term results of radiosurgery for refractory cluster headache. Neurosurgery. 2006, 59: 1258-1262. discussion 1262-1253

    PubMed  Google Scholar 

  93. Leone M, Franzini A, Broggi G, Bussone G: Hypothalamic deep brain stimulation for intractable chronic cluster headache: a 3-year follow-up. Neurol Sci. 2003, 24 (Suppl 2): S143-145.

    PubMed  Google Scholar 

  94. Leone M, Franzini A, Broggi G, Bussone G: Hypothalamic stimulation for intractable cluster headache: long-term experience. Neurology. 2006, 67: 150-152. 10.1212/01.wnl.0000223319.56699.8a.

    Article  PubMed  Google Scholar 

  95. Schoenen J, Di Clemente L, Vandenheede M, Fumal A, De Pasqua V, Mouchamps M, Remacle JM, de Noordhout AM: Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of action. Brain. 2005, 128: 940-947. 10.1093/brain/awh411. Epub 2005 Feb 2002

    Article  CAS  PubMed  Google Scholar 

  96. Bartsch T, Pinsker MO, Rasche D, Kinfe T, Hertel F, Diener HC, Tronnier V, Mehdorn HM, Volkmann J, Deuschl G, Krauss JK: Hypothalamic deep brain stimulation for cluster headache: experience from a new multicase series. Cephalalgia. 2008, 28: 285-295. 10.1111/j.1468-2982.2007.01531.x.

    Article  CAS  PubMed  Google Scholar 

  97. Pinsker MO, Bartsch T, Falk D, Volkmann J, Herzog J, Steigerwald F, Diener HC, Deuschl G, Mehdorn M: Failure of deep brain stimulation of the posterior inferior hypothalamus in chronic cluster headache – report of two cases and review of the literature. Zentralbl Neurochir. 2008, 69: 76-79. 10.1055/s-2007-1022558.

    Article  CAS  PubMed  Google Scholar 

  98. May A: Hypothalamic deep-brain stimulation: target and potential mechanism for the treatment of cluster headache. Cephalalgia. 2008, 28: 799-803. 10.1111/j.1468-2982.2008.01629.x.

    Article  CAS  PubMed  Google Scholar 

  99. Burns B, Watkins L, Goadsby PJ: Treatment of medically intractable cluster headache by occipital nerve stimulation: long-term follow-up of eight patients. Lancet. 2007, 369: 1099-1106. 10.1016/S0140-6736(07)60328-6.

    Article  PubMed  Google Scholar 

  100. Leone M, Franzini A, Cecchini AP, Broggi G, Bussone G: Stimulation of occipital nerve for drug-resistant chronic cluster headache. Lancet Neurol. 2007, 6: 289-291. 10.1016/S1474-4422(07)70061-3.

    Article  PubMed  Google Scholar 

  101. Schwedt TJ, Dodick DW, Trentman TL, Zimmerman RS: Occipital nerve stimulation for chronic cluster headache and hemicrania continua: pain relief and persistence of autonomic features. Cephalalgia. 2006, 26: 1025-1027. 10.1111/j.1468-2982.2006.01142.x.

    Article  CAS  PubMed  Google Scholar 

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Leroux, E., Ducros, A. Cluster headache. Orphanet J Rare Dis 3, 20 (2008).

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