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A systematic literature review on the health-related quality of life and economic burden of Fabry disease

Abstract

Background

Fabry disease (FD) is a rare lysosomal storage disease associated with glycolipid accumulation that impacts multiple physiological systems. We conducted a systematic literature review (SLR) to characterize the humanistic (quality of life [QoL]) and economic burden of FD.

Methods

Searches were conducted in the Embase, MEDLINE®, and MEDLINE® In-Process databases from inception to January 19, 2022. Conference abstracts of specified congresses were manually searched. Additional searches were performed in the Cochrane and ProQuest databases for the humanistic SLR and the National Health Service Economic Evaluations Database for the economic SLR. Studies of patients with FD of any sex, race, and age, and published in the English language were included. There was no restriction on intervention or comparator. For the humanistic SLR, studies that reported utility data, database/registry-based studies, questionnaires/surveys, and cohort studies were included. For the economic SLR, studies reporting economic evaluations or assessing the cost of illness and resource use were included.

Results

Of the 1363 records identified in the humanistic search, 36 studies were included. The most commonly used QoL assessments were the 36-item Short-Form Health Survey (n = 16), EQ-5D questionnaire descriptive system or visual analog scale (n = 9), and the Brief Pain Inventory (n = 8). Reduced QoL was reported in patients with FD compared with healthy populations across multiple domains, including pain, physical functioning, and depressive symptoms. Multiple variables—including sex, age, disease severity, and treatment status—impacted QoL. Of the 711 records identified in the economic burden search, 18 studies were included. FD was associated with high cost and healthcare resource use. Contributors to the cost burden included enzyme replacement therapy, healthcare, and social care. In the seven studies that reported health utility values, lower utility scores were generally associated with more complications (including cardiac, renal, and cerebrovascular morbidities) and with classical disease in males.

Conclusion

FD remains associated with a high cost and healthcare resource use burden, and reduced QoL compared with healthy populations. Integrating information from QoL and economic assessments may help to identify interventions that are likely to be of most value to patients with FD.

Introduction

Fabry disease (FD; OMIM 301500) is a rare, multisystemic, X-linked inherited disorder of glycosphingolipid metabolism, which occurs as a result of decreased activity of the lysosomal enzyme α-galactosidase A (α-Gal A) [1,2,3]. The reduction in α-Gal A activity is caused by pathogenic variants in the α-Gal A gene (GLA) [1,2,3]. Functional α-Gal A breaks down glycolipids (i.e. globotriaosylceramide [GL-3 or Gb3], its deacylated form lyso-GL-3/Gb3 and related glycolipids). When normal α-Gal A activity is deficient, glycolipids accumulate across multiple physiological systems, including the renal, cardiovascular, and nervous systems [1,2,3].

There are two main phenotypes of FD: the more severe ‘classical’ form, and the variant ‘non-classical’ or ‘late-onset’ form [4]. As expected with an X-linked disease, both types of FD are more prevalent in men than in women [4]. Patients with classical FD have very low to no α-Gal A activity [5]; among patients with non-classical FD, there is greater heterogeneity in the level of α-Gal A activity [6]. The variation in α-Gal A activity levels in non-classical FD results in attenuated and variable disease presentation [6]. Early symptoms of classical FD include neuropathic pain, angiokeratomas, anhidrosis, and gastrointestinal symptoms [4]. The rate of disease progression of FD can vary considerably between patients [7].

The current standard of care for patients with FD is intravenous enzyme replacement therapy (ERT) with agalsidase alfa (Replagal®, Takeda Pharmaceuticals International AG) or agalsidase beta (Fabrazyme®, Sanofi Genzyme) [8,9,10,11]. Treatment with long-term ERT is costly and burdensome for patients [8, 12]. Therefore, treatment is generally limited to those at high risk or with evidence of major organ involvement. ERT is recommended for all adult male patients with classical FD [8, 9]. For those patients with an amenable GLA variant, oral chaperone therapy with migalastat (Galafold™, Amicus Therapeutics Inc.) can also be used for treatment [13]. ERT has been previously shown to have a positive impact on the quality of life (QoL) of patients with FD, as well as to preserve organ function, reducing cardiovascular and renal complication rates in patients who started treatment before the onset of irreversible organ damage [14, 15]. Early intervention with ERT in patients with FD may prevent progression to cardiovascular and end-stage renal disease (ESRD). However, current challenges include identifying patients who would benefit from early intervention and defining the optimum time of treatment initiation [16].

The overall burden of FD can be described as humanistic, given the number of progressively declining health issues that can directly affect patients’ QoL, and economic, given the high costs associated with managing the disease (treatment, hospitalizations, doctor visits, surgeries, diagnosis, and tests) and improving patients’ QoL. The importance of measuring QoL and capturing the humanistic impact of the disease (emotional, psychological, social, and physical function) is well documented in patients with FD [4]. A variety of questionnaires have been used to assess QoL in patients with FD, including the 36-item Short-Form Health Survey (SF-36), the EuroQol five dimension (EQ-5D) questionnaire, the 100-item World Health Organization Quality of Life scale (WHO QoL-100), the Brief Pain Inventory (BPI), and a visual analog scale (VAS) [4]. In a 2015 systematic review, Arends and colleagues described the negative impact of FD on patients’ QoL as assessed with the SF-36, EQ-5D, EQ-VAS, and BPI [4]. There are also assessments that focus on the mental well-being of patients, such as the Centre of Epidemiologic Studies Depression Scale (CES-D) and the Hospital Anxiety and Depression Scale (HADS) [17, 18], and scales to monitor impact on sleep, such as the Epworth Sleepiness Scale (ESS) [19]. Moreover, there are QoL assessments designed for pediatric populations, including the Pediatric Quality of Life Inventory (PedsQL), the Children’s Depression Inventory (CDI), the Behavior Assessment Scale for Children (BASC; available in multiple editions), and the Fabry-specific Pediatric Health and Pain Questionnaire (FPHPQ) [4, 20,21,22].

Health technology assessments (HTAs), required for reimbursement of therapies, tend to include some form of economic evaluation alongside clinical data of therapeutic benefit (notably, efficacy and safety data) [23]. Few countries include QoL, let alone health-related QoL, as criteria for reimbursement [23]. Previous research has also shown that traditional outputs for economic models may not be sensitive to the severity of rare diseases, potentially owing to the smaller populations with severe disease and the proportionally smaller improvements in health outcomes compared with those observed in larger, healthier populations [24].

Evidence synthesis is important for rare diseases such as FD, particularly given its wide phenotypic heterogeneity and relatively small study populations. Accordingly, we conducted a systematic literature review (SLR) to provide a comprehensive characterization of the current disease burden of FD, with focus on the humanistic impact on patients’ QoL (assessed with a broad range of tools) and the economic burden of disease (including healthcare resource utilization and costs). By reviewing these two aspects together, we aim to capture the overall burden of FD, both on patients and on wider society.

Methods

This SLR was undertaken in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines [25]. Two separate searches were conducted to look at humanistic burden (with a focus on QoL) and economic burden (with a focus on healthcare resource utilization, costs, and economic evaluations). Key biomedical electronic literature databases were searched from inception to January 19, 2022. Embase®, MEDLINE®, and MEDLINE® In-Process were searched for both the humanistic and economic burden, using Embase® and PubMed platforms; in addition, the National Health Service (NHS) Economic Evaluations Database (EED; via the Cochrane library interface and the EconLit database) was used for the economic search, and Cochrane and ProQuest were used for the humanistic burden search. The search strategy was formulated in accordance with the list of databases suggested by HTA agencies such as the National Institute for Health and Care Excellence (NICE) and the Scottish Medicines Consortium.

In addition to the database search, conference abstracts were hand searched to retrieve the latest studies. Relevant conferences for abstract screening included (for both searches unless otherwise stated): the Fabry Family Education Conference, the Lysosomal Diseases Conference, the European Conference on Recent Advances in Lysosomal Diseases, the International Society for Pharmacoeconomics and Outcomes Research (economic search only), the Society for the Study of Inborn Errors of Metabolism (SSIEM), and the We’re Organizing Research on Lysosomal Diseases (WORLD) Symposium. Additional economic sources were searched for outcomes and subgroups of interest that were not available in the publications, including the Food and Drug Administration (FDA), the European Medicines Agency (EMA), the National Institute for Health Research (NIHR)-HTA, and other HTA websites. Full details of both searches are provided in Additional file 1: Table 1.

Eligibility criteria are summarized in Additional file 1: Table 2. All results were limited to studies published in English. For both searches, all adults and children with a confirmed diagnosis of FD were included, and there was no restriction on intervention or comparator. For the humanistic burden evidence search, studies providing utility data, database/registry-based studies, questionnaires/surveys, and cohort studies (prospective/retrospective observational) were included. For the economic evidence search, studies reporting economic evaluations or assessing the cost of illness and resource use were included.

Data collection and extraction

Two independent reviewers conducted the first screening of all titles and abstracts only, followed by a second screening based on full-text articles. Two independent reviewers also conducted the data extraction from each of the included studies. Any discrepancies between the decisions of the two reviewers at any stage were resolved by a third independent reviewer; overall, the third reviewer intervened to establish the inclusion of one publication [26] and the exclusion of three publications due to lack of relevant QoL data. If more than one publication was identified describing a single study, the data were compiled into a single entry in the data extraction table to avoid the multiple counting of patients and studies. Each publication was referenced in the table to recognize that more than one publication may have contributed to the entry.

Outcome measures

Using a predefined extraction process, key data including study details, study characteristics, patient characteristics at baseline, QoL outcomes of interest, and resource utilization were recorded.

Methodological appraisal

For the economic burden SLR, the quality of identified studies was evaluated using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist, the Philips checklist, and the NICE single technology appraisal-adapted Drummond’s checklist. The CHEERS checklist, developed by the Professional Society for Health Economics and Outcomes Research (ISPOR) Health Economic Evaluation Publication Guidelines Reporting Practices Task Force, outlines a 24-item reporting guideline checklist to assess the overall reporting quality of economic evaluations [27]. The Philips checklist is recommended to inform critical appraisal of the quality of economic modeling study methods [28], and the adapted Drummond’s checklist critically appraises the methodology of cost burden and resource use studies [29].

Results

Humanistic burden SLR

Identified studies

For the humanistic burden evidence, the initial electronic literature search identified 1363 records. Following the screening process, 36 studies (from 41 publications reporting QoL outcomes in patients with FD) were included in the analysis (Fig. 1A; Table 1A). Of the 36 included studies, 29 reported QoL outcomes in both male and female patients, of which eight studies reported data by sex. Four studies reported results only in female patients, and three studies reported results only in male patients. Three studies assessed a purely pediatric population.

Fig. 1
figure 1

PRISMA flow diagram for the studies across the humanistic (a) and economic (b) searches. aDatabases included Embase®, MEDLINE®, Cochrane, PubMed and ProQuest. ProQuest was utilized for initial review conducted in January 2020; for the refresh of the current review (conducted in January 2022) only Embase®, Cochrane, and PubMed were utilized, in line with the protocol. bIn addition to the assessment of QoL, four studies from the economic burden SLR reported utility values with EQ-5D index scale. The EQ-5D results were included in the humanistic burden SLR and the utility values from these studies were included in the economic burden SLR. cFour studies were retrieved from humanistic burden review as a part of bibliography. Some publications contained more than one economic study type; the numbers of publications by type are therefore not mutually exclusive. SGA, subgroup analysis

Table 1 Summary of included studies from humanistic (A) and economic (B) searches

Identified studies were conducted at both a global and country level and varied by study type. Nine studies were conducted in the USA, five studies were conducted in the UK, two studies each were conducted in Germany and Norway, and one study each was conducted in Australia, Brazil, Canada, Denmark, Italy, Netherlands, Poland, Spain, and Switzerland. Two studies reported data globally, while study country was not reported in four studies. Three studies were conducted in two countries (one in Germany and Austria, one in Germany and Switzerland, and one in the Netherlands and the UK).

Half of the studies in this analysis were cohort studies (n = 18), and the remaining studies were cross-sectional (n = 9), registry-/survey-based studies (n = 6), or case–control studies (n = 3). The sample size across the included studies ranged from 6 to 2236 patients. There were 32 studies that reported a mean/median age, which ranged from 8.9 to 56.5 years.

In total, 25 different instruments were used to assess QoL across the included studies. These instruments included general QoL scales and specific symptom scales; descriptions of the tools and a summary of their use across studies are provided in Additional file 1: Table 3. SF-36, BPI, and EQ-5D were used most often across the identified studies.

Normative populations refer to the general population or healthy controls, as applicable; these populations were included for comparison with patients with FD.

Impact of FD on overall QoL

QoL findings from studies using SF-36 and the 12-item Short-Form Health Survey (SF-12)

The SF-36 questionnaire is a generic instrument used to measure health-related QoL, with 36 questions covering aspects of physical and psychological functioning (each domain is scored from 0 [worst] to 100 [best]). The SF-12 is a shortened version of the SF-36 questionnaire, covering the same domains. SF-36 was used in 16 studies [19, 26, 30,31,32,33,34,35,36,37,38,39,40,41,42,43,44].

SF-36 scores in FD compared with normative populations

In 9 of the 16 studies, data were available comparing SF-36 scores in the reported FD population to a relevant normative population (Table 2). Overall, when compared with the general population or healthy controls, reduced QoL was reported among patients with FD across a range of domains, with some studies reporting a significant impact across every domain studied. Among those studies with statistical significance of differences calculated, physical functioning, bodily pain, and general health perception were the domains most frequently affected. No statistical comparisons were reported between patients with FD and age-matched controls.

Table 2 Summary of SF-36 domain scores in patients with FD compared with normative populations
Impact of patients’ sex on SF-36 scores

Seven studies analyzed SF-36 scores in both male and female patients, with two performing a direct statistical comparison between sexes [30, 32, 33, 37, 39, 41, 44]. In the study by Rosa Neto and colleagues, only scores in the general health perception domain differed significantly between male and female patients (female mean [standard deviation, SD], 56.4 [20.7]; male mean [SD], 39.1 [17.1]; p = 0.01) [37]. In the study by Pihlstrom and colleagues, however, only the emotional role domain differed significantly (female median [interquartile range], 100 [22.9]; male mean [SD], 73.4 [18.1]; p = 0.012) [44]. Overall, SF-36 scores were generally lower in male patients compared with female patients.

Impact of patients’ age on SF-36 scores

Two studies evaluated the impact of age on SF-36 scores [31, 39]. Wilcox and colleagues presented findings across six age groups (youngest 18–24 years; oldest ≥ 65 years), highlighting that, for both male and female patients, the most significant differences compared with the relevant normative population were among those aged 35–55 years (≥ 7 of 8 domains significantly different) [39]. Generally, while male patients had lower mean scores than female patients at a younger age, female patients experienced a greater decline in scores over time than male patients [39]. In the study by Gold and colleagues, patients were categorized into three age groups (< 20 years, 20–40 years, and > 40 years); SF-36 domain scores generally decreased with age, with the largest decreases observed between the 20–40 years and the older than 40 years age groups [31].

Impact of kidney function impairment on SF-36 scores

One study, by Wagner and colleagues, stratified SF-36 scores according to kidney function based on three groups: estimated glomerular filtration rate (eGFR) 60 mL/min or higher (preserved), eGFR below 60 mL/min (moderately impaired), and patients receiving renal replacement therapy (RRT) (severely impaired) [38]. Significant differences were observed between the groups across all SF-36 domains; physical domains were affected even in patients with moderately impaired kidney function, whereas an impact on mental/emotional and physical domains was observed mainly in those with severely impaired function.

Impact of length of treatment with ERT on SF-36 scores

Three studies evaluated how SF-36 scores are affected by the length of time a patient has received ERT [26, 34, 40]. In a longitudinal cohort study that recruited 311 patients, Wyatt and colleagues reported that, after adjusting for age, patients who had received ERT for more than 3 years had significantly lower scores than those who had been treated for up to 3 years [40]. In contrast, in a cross-sectional study, Low and colleagues found no significant changes in any domain scores over 21 months of follow-up (n = 40) [34]. The studies by Wyatt and colleagues and Low and colleagues, however, differed in both sample size and follow-up time, which may provide an explanation for the contrasting conclusions. Owing to the progressive nature of FD, different treatment lengths and follow-up time are likely to considerably affect results. The study by Lachmann and colleagues focused on home treatment with ERT and found that both physical and mental component summary scores increased following the switch from clinic-based infusions to home-based infusions [26]. No studies were identified that evaluated how SF-36 scores are affected by time receiving oral chaperone therapy. A fourth study by Sigurdardottir and colleagues found that SF-36 scores remained unchanged over a 7–13-year follow-up in a mixed population of male and female patients receiving ERT or chaperone or neither therapy. However, this study did not assess the effect of therapy on SF-36 score [43].

SF-12 findings

One study used SF-12—a shorter questionnaire than SF-36—to assess QoL in patients with FD aged 45 years or older [42]. Physical and mental component scores were significantly lower in patients with FD compared with controls.

Impact of FD on QoL as measured by EQ-5D
EQ-5D descriptive system findings

The EQ-5D descriptive system asks respondents to report the extent of the problems they experience across five different dimensions. Five studies evaluated the impact of FD on QoL in different patient populations using the EQ-5D descriptive system [35, 41, 45,46,47], and domain-specific findings are presented in Fig. 2A. In nearly all studies, problems were reported by some patients in each domain evaluated. Pain/discomfort was the most frequently affected domain in all studies except the study by Barba-Romero and colleagues [46].

Fig. 2
figure 2

EQ-5D findings from studies using the descriptive system (a) and the VAS (b). aThe proportion of patients with ‘no problems’ was calculated using a subtractive approach based on the proportions of patients with ‘moderate problems’ or ‘extreme problems’ for Żuraw et al. [41]. b‘Extreme problems’ was expressed as ‘confined to bed’ for all dimensions in in Miners et al. [35] and for the mobility dimension in Polistena et al. [47]. cNo normative population comparator was included for Barba-Romero et al. [46] or Żuraw et al. [41]. Data obtained from Arends et al. [45], Barba-Romero et al. [46], Löhle et al. [33], Low et al. [34], Miners et al. [35], Nowak et al. [48], Polistena et al. [47], Santamaria et al. [49], and Żuraw et al. [41]. Error bars represent standard deviations, where reported

EQ-5D descriptive findings compared with normative population

The study by Miners and colleagues focused on EQ-5D descriptive findings in males with FD in the UK (n = 38), with comparison with a sample from the general UK male population (n = 1466) [35]. The proportion of patients experiencing problems was significantly higher than in the general population (p ≤ 0.001) across all dimensions.

Impact of patients’ sex and FD type on EQ-5D descriptive findings

Arends and colleagues evaluated EQ-5D results according to sex and diagnosis with classical or non-classical FD [45]. Among patients with classical disease [76 men and 76 women], a higher proportion of men than women experienced moderate or extreme problems in nearly all dimensions, with exceptions among patients with extreme problems with pain (9.4% of women compared with 5.3% of men) and anxiety/depression (similar proportions between sexes experiencing moderate problems, and no men or women experiencing extreme problems). Among those with non-classical disease (38 men and 76 women), the trend was less clear, with similar proportions of men and women experiencing moderate or extreme problems across dimensions, and women being more likely to experience extreme problems with self-care, usual activities, and pain and discomfort. Overall, the proportions of patients experiencing problems were similar between the classical and non-classical groups.

The prospective, cross-sectional study by Żuraw and colleagues, which included 20 men and 13 women, also identified that a higher proportion of men than women experienced problems across all dimensions, except anxiety/depression, with the biggest difference being observed in mobility (45% of men reporting moderate problems compared with 15% of women) [41].

Impact of ERT on EQ-5D descriptive findings

Żuraw and colleagues also looked at the impact of ERT on EQ-5D (n = 14 patients receiving ERT; n = 6 patients not on ERT) [41]. Higher proportions of patients with ‘any problems’ were reported across most dimensions in the ERT group; however, extreme problems were more common in the no ERT group (17%; [1 patient] with extreme problems in self-care and usual activities vs 0% in the ERT group; 50% [3 patients] with extreme pain/discomfort vs 7% [1 patient] in the ERT group).

Impact of health state on EQ-5D descriptive findings

Arends and colleagues evaluated the association of problems reported via the EQ-5D with health states [45]. Patients were asked to select from ‘no problems’, ‘some/moderate problems’, or ‘extreme problems’ for each EQ-5D domain. Among those patients with a relevant clinical event (neuropathic pain, organ involvement, ESRD, cerebrovascular accident, cardiac complications, or multiple complications), a higher proportion of patients experienced problems across most QoL domains compared with the asymptomatic group. For all dimensions except anxiety/depression, the patients with multiple complications (n = 18) were most likely to have experienced moderate or extreme problems.

EQ-5D VAS findings compared with normative population

The EQ-5D VAS rates QoL on a scale of 0 (worst imaginable health status) to 100 (best imaginable health status). Seven studies assessed QoL using this instrument [33,34,35, 41, 46, 48, 49]; one of these (Nowak and colleagues) is described in a preprint article [48]. An overview of mean VAS scores is presented in Fig. 2B. Mean VAS scores were generally similar for patients with FD across studies, ranging from 65–79, with the exception of the study by Miners and colleagues (a lower mean score of 24.3). Among the studies comparing scores to a relevant normative population, all reported a significantly lower mean score in the patient population compared with controls (p ≤ 0.02 in all three studies).

Impact of patients’ sex and ERT on EQ-5D VAS findings

Three studies evaluated EQ-5D VAS scores according to sex (Fig. 2B), each of which reported a numerically higher mean score in female patients than in male patients: 76.8 versus 72.6, 72 versus 65, and 75.8 versus 69.7 for females versus males across the three studies by Löhle, Żuraw, and Nowak, respectively, although none of these differences between sexes were statistically significant [33, 41, 48]. Żuraw and colleagues also analyzed the impact of ERT on EQ-5D VAS scores [41]. There was no difference between the ERT and no ERT groups, with a reported mean score of 65 in both groups. In contrast, Nowak and colleagues found that patients in the no ERT group (n = 24) had a significantly lower mean score compared with patients treated with ERT (n = 100) [48]. No studies were identified that analyzed the impact of oral chaperone therapy on EQ-5D VAS scores.

Impact of FD on QoL in children as measured by PedsQL

The PedsQL 4.0 instrument uses 23 items across four dimensions to evaluate QoL in children, giving a score from 0 to 100 (higher scores indicating better QoL). Two studies used the PedsQL 4.0 to assess QoL in children with FD [20, 40].

In the US case–control study performed by Bugescu and colleagues, children with FD self-reported significantly lower QoL than controls across all health dimensions, with the exception of emotional functioning; however, according to the parental report, QoL was lower across all domains (including emotional functioning) [20]. PedsQL scores were significantly lower in younger children than in adolescents (mean total score 68.20 vs 82.05; p = 0.007 for child self-report) and numerically higher in children receiving ERT compared with those not receiving ERT (difference not significant).

Wyatt and colleagues performed a longitudinal cohort study in the UK and evaluated the effect of treatment with ERT on PedsQL scores [40]. Scores were highest in all domains for patients not receiving ERT. Among those receiving ERT, scores were higher for patients treated for up to 3 years than for those treated for longer (statistical significance not calculated). However, PedsQL scores decreased significantly with age (p = 0.03) and, after adjusting for age, no relationship between time on ERT and any PedsQL subscale was observed.

Impact of FD on QoL in children as measured by Child Health Questionnaire (CHQ)

The CHQ is used to assess health-related QoL in children and adolescents, and includes both physical and psychosocial concepts. One study, by Ries and colleagues, used the CHQ to evaluate QoL in 25 male children with FD and 21 age-matched controls [50]. For patients younger than 10 years of age with FD (n = 9), mean QoL scores were numerically lower compared with controls (n = 212) across all aspects; however, only bodily pain and mental health scores were significantly different. For patients with FD and aged 10 years or older (n = 15), only the bodily pain score was significantly lower than the control value.

Additional QoL findings based on tools/instruments used in single studies

Several additional instruments were used to assess QoL in single studies identified in the literature review; the findings generally support a consistent picture of reduced QoL in patients with FD (Additional file 1: Table 4).

Two studies developed FD-specific instruments to assess QoL in patients [41, 51]. Żuraw and colleagues developed an ‘author’s questionnaire’ based on the literature, personal experiences, patient-related observations, and patient-collected information [41]. Self-perceived health status was evaluated, with some patients reporting ‘bad’ health status across all symptoms studied, most commonly for burning extremity pain (34%). After ERT, an improvement in symptoms was perceived for at least 50% of patients in each symptom category. An FD-specific questionnaire was also developed by Morier and colleagues (the ‘Patient Health and Lifestyle Questionnaire’) [51]. Most patients reported that FD impacted their QoL to some extent, with varying degrees of severity. An impact on QoL of any severity was reported by 87.5% of men compared with 60.0% of women. In comparison, the proportion of patients who reported that their life was greatly impacted was similar between men and women (12.5% vs 13.3%).

Impact of pain in FD

Pain in FD as measured using the BPI

The BPI assesses the severity of pain and the impact of pain on daily functions using scales of 1–10, with 10 being most severe or highest level of interference. A ‘pain severity index’ can be calculated as the arithmetic mean across the four severity items, and a ‘pain interference index’ as the arithmetic mean across the seven interference items.

BPI scores in FD overall and compared with normative populations

Eight studies reported BPI pain scores in FD; scores for those reporting data for the overall study population are summarized in Table 3 [32, 33, 37, 39, 45, 46, 49, 52]. Although all studies reported some degree of pain experienced by patients with FD, the severity and interference were variable within and between studies, and average pain scores tended to be towards the lower end of the scale (a BPI pain score < 5, which indicates mild pain). In the study by Löhle and colleagues, which compared findings to age-matched controls without FD, the average pain severity and interference with daily activities were significantly higher in patients than in controls (p = 0.002 and p = 0.003, respectively) [33].

Table 3 Summary of overall BPI scores and impact of sex, age, and disease subtype on BPI scores in patients with FD
Impact of patient sex, age, and FD subtype on BPI findings

Hopkin and colleagues reported that the first recorded BPI score for ‘worst pain in the past 24 h’ was significantly higher in male versus female pediatric patients (aged 12–17 years; mean [SD], 4.4 [3.51] vs 1.5 [2.45]; p < 0.02), but they found no significant difference between sexes in the first recorded BPI score for average pain (Table 3) [32]. By contrast, Löhle and colleagues found that female patients, compared with male patients (all patients aged 17.3–84.4 years), had numerically higher pain severity index and function interference index [33]. The differences in the ages of the patient populations enrolled may explain the discrepancy between study findings. Wilcox and colleagues evaluated age and sex differences in BPI scores in patients aged 12 years and over [39]. In female patients, mean scores for average and worst pain were lower compared with in male patients up to the age of 40 years, but they were higher thereafter, suggesting a worsening of pain over time in female patients compared with relative stability in male patients. Arends and colleagues evaluated the effect of FD subtype and sex on BPI scores [45]. In male patients, median scores for average and worst pain were higher in those with classical versus non-classical disease, but this was not the case for female patients. Furthermore, the median interference score among males was higher for those with classical versus non-classical disease, while the opposite was true for females (higher for those with non-classical versus classical disease).

Impact of disease severity on BPI findings

Rosa Neto and colleagues compared BPI scores between patient groups classified according to FD severity [37]. Differences were limited between the ‘severe’ and ‘moderate’ groups, with the lowest scores observed in the ‘mild’ group. The mean (SD) BPI severity scores for patients with severe, moderate, and mild disease were 2.78 (2.66), 2.80 (2.55), and 1.55 (2.38), respectively, and the mean (SD) BPI interference scores were 2.55 (2.44), 2.80 (3.18), and 1.36 (2.83), respectively.

Impact of BPI score on QoL as assessed by the EQ-5D

Arends and colleagues included an evaluation of the relationship between BPI scores and EQ-5D utility scores [45]. Utilities significantly decreased with higher BPI scores, with an average 0.045 decrease in EQ-5D utility for every one-point increase in BPI average pain score (p < 0.001), indicating a relationship between increasing pain and worsening QoL for patients with FD.

Pain in FD as measured using a VAS for pain

Two studies used a VAS to assess pain, with a scoring system based on a range between 0 (no pain) and 10 (maximal pain) [38, 53]. Torvin Møller and colleagues assessed pain among female patients with FD in Denmark, reporting a median VAS score of 4.0 (range 1–7); 63% of patients noted that they experienced daily pain, and 42% reported pain crises within the past week [53]. A significant correlation was observed between age and VAS score in this population (p = 0.017). In the study by Wagner and colleagues, pain was assessed using the VAS according to chronic kidney disease (CKD) stages [38]. The median VAS score was similar across the three CKD groups: 2 (interquartile range, 1–3) in patients with eGFR 60 mL/min/1.73 m2 or higher, 2 (0–3) in patients with eGFR less than 60 mL/min/1.73 m2, and 2 (2–3) in patients receiving RRT.

Pain in FD as measured using the Numerical Rating Scale (NRS) for pain

Gibas and colleagues developed a questionnaire with 5-point scales for specific assessment of FD symptomatology, including pain [54]. Findings from the NRS questionnaire indicated significant variability between FD-related pain intensity and unpleasantness at its least, average, and worst (mean intensity ranging from 1.59 for ‘least’ pain to 4.43 for ‘worst’ in male patients and from 1.72 to 3.88 in female patients; mean unpleasantness ranging from 1.84 for ‘least’ pain to 4.38 for ‘worst’ pain in male patients and from 1.86 to 4.02 in female patients). Age was significantly correlated with FD-related pain at its worst for males (p < 0.05) but not for females. FD-related pain was rated as significantly more intense than other types of pain in patients overall, as well as in male and female subgroups.

Joint pain in FD as measured using the Joint Pain Questionnaire

One study used the Joint Pain Questionnaire to evaluate the impact of joint pain on daily life for patients with FD [55]. The proportion of patients with FD reporting current joint pain or swelling was higher than in age-matched controls (43.0% vs 25.0% for the male group and 39.0% vs 33.0% for the female group). Greater differences between patients and age-matched controls were observed when considering only those under 50 years of age (40.0% of male patients and 25.0% of female patients with current joint pain or swelling compared with 0% and 8.3% of age-matched male and female controls, respectively; p = 0.03 for the male comparison). There was also a higher proportion of patients overall than age-matched controls who had experienced joint swelling or joint pain lasting more than 4 continuous weeks (21.0% vs 14.0% for joint swelling, and 29.0% vs 14.0% for joint pain).

Mental health in FD

Depressive symptoms

Six studies evaluated depressive symptoms in patients with FD (Table 4) [20, 33, 42, 49, 56, 57]. Two studies used the CES-D, with scores ranging from 0 to 60 and higher scores indicating more depressive symptoms [42, 56]. In one of these studies by Blackler and colleagues, 42% of patients reported depressive symptoms, with 27% having severe symptoms; in the other study by Wadley and colleagues, there was a significantly higher proportion of patients with FD versus controls that had elevated depressive symptoms (28% vs 10%; p = 0.007). A study by Löhle and colleagues employed the Beck Depression Inventory-II (BDI-II) to assess depressive symptoms (higher scores indicating more severe depressive symptoms; maximum score 63) and reported a significantly higher mean BDI-II score in patients with FD versus age-matched controls, overall (9.8 vs 3.5; p < 0.0001) and in male (8.0 vs 3.2; p < 0.01) and female (11.3 vs 3.8; p < 0.01) subgroups [33]. In addition, the proportions of patients defined as having depression regardless of severity and of those defined as having severe depression were higher in patients with FD than in controls (26.8% vs 3.5% and 8.2% vs 0.0%, respectively; both p < 0.05).

Table 4 Summary of mental health assessments in FD

Single studies assessed depressive symptoms in patients with FD based on the Hamilton Rating Scale for Depression-17 (HAM-D) and CDI [20, 57]. Loeb and colleagues found no significant differences in HAM-D scores between male and female patients or between those with and without cognitive impairment [57]. In the case–control study by Bugescu and colleagues, there were no significant differences in CDI-2 total score, scales, and subscales between patients with FD and previously established reference values for healthy individuals, although the small sample size (n = 24) may have impacted this result [20]. Despite this, 21% of patients with FD reported levels of depressive symptoms within the clinical range [20]. Another single study used the HADS and reported the prevalence of anxiety and of depression to be 45% and 21%, respectively, in patients with confirmed FD (aged > 14 years) [49].

Perceived stress levels, sleep, and fatigue

Wadley and colleagues reported a significantly higher score on the Perceived Stress Scale—4 items (PSS-4), indicating greater levels of perceived stress, in patients with FD compared with a control group (mean [SD], 6.2 [2.3] vs 3.2 [2.7]; p < 0.0001) (Table 4) [42]. Two studies, by Gaisl and colleagues and Löhle and colleagues, employed the ESS to assess average level of daytime sleepiness in patients with FD (a higher score corresponding to increased sleepiness; maximum score of 24); both showed greater daytime sleepiness in patients with FD compared with controls (7.6 vs 6.3 points [p = 0.01] and 7.2 vs 5.1 points [p = 0.009], respectively) [19, 33]. In addition, Löhle and colleagues reported that a higher proportion of patients with FD had significant sleepiness (score ≥ 10 points) compared with controls (25.7% vs 19.3%). Löhle and colleagues also performed an evaluation of features of rapid eye movement sleep behavior disorder (RBD) among patients with FD using the RBD Screening Questionnaire (RBDSQ) (Table 4) [33]; higher scores using this tool indicate more features associated with RBD (maximum score of 13). Comparable mean RBDSQ scores were reported for patients with FD compared with controls, indicating similar sleep behavior across the groups. There was, however, a higher proportion of patients with FD reporting as RBD positive (score ≥ 5) than of the control group (26.6% vs 14.0%).

In a study by Duning and colleagues, the prevalence of chronic fatigue in patients with mild to moderate FD, as assessed with the Fatigue Severity Scale (FSS), was 45% [58].

Economic burden SLR

Identified studies

For the economic burden of evidence review, the initial electronic literature search identified 711 records. Following the screening process, 18 studies (from 19 publications) were included in the analysis; two studies (from three publications) reported economic evaluations, 11 (from 11 publications) reported cost burden and resource use, and seven (from seven publications) reported utility review (Fig. 1B; Table 1B). The two economic evaluation studies (one conducted in the Netherlands, and one in Japan) both included male and female patients.

Of the 11 studies reporting cost burden and resource use, two each were conducted in Colombia, Spain, and the USA, and one each in Germany, Italy, Norway, and the UK; one did not report a location. There were four retrospective studies, two budget-impact studies, a cross-sectional study, a simulation model study, a cost analysis, a cost-utility analysis, and a cost-of-illness analysis/HTA report.

Three of the studies reporting utility/disutility data were conducted only in the UK, one only in the Netherlands, one in the Netherlands and the UK, one in Italy, and one in Germany and Switzerland. There were two cohort studies, two cross-sectional studies, one cost-effectiveness analysis, one database registry study (conducted in males only), and one survey (discrete choice experiment).

Studies identified for each section were not mutually exclusive. One of the two economic evaluation studies also provided utility data; the remaining six utility studies were also identified in the humanistic burden SLR.

Economic evaluation of treatment for FD

The first of the two identified economic evaluation studies, performed by Rombach and colleagues, was a cost-effectiveness analysis in the Netherlands, comparing ERT with standard medical care from a societal perspective [59]. The second study, conducted by Inoue and colleagues, was a cost-minimization analysis performed in Japan, comparing migalastat with ERT (agalsidase alfa or beta) from both public healthcare and societal perspectives [60]. Both studies used a lifetime Markov state-transition model and a 1-year cycle length. Clinical data were obtained from various sources, including Phase 3 clinical trials, published literature, and the SEER database; cost data were sourced from published literature, medical records, official tariffs, and price lists; and resource use data were sourced from case reports and published literature [59, 60]. The Dutch study was based on 2009 costing with no discounting for the base-case (univariate analysis was restricted to the choice of discount rate to account for time preference: discounting of effects by 1.5% and costs by 4%) [59]. A discount rate of 2% was applied in the Japanese study; no cost year was reported [60].

The Dutch study indicated that, for patients with FD receiving ERT, the related incremental cost-effectiveness ratio (ICER) per quality-adjusted life-year (QALY), or per year free of end-organ damage (YFEOD) ranged from €3.2 million (discounted) to €6.5 million (without discounting) across the study [59]. ERT provided higher QALYs and YFEOD compared with no ERT (50.2 vs 48.6 and 56.5 vs 55.0, respectively). Total lifetime cost was lower with no ERT than with ERT (€270,964 vs €9,918,352). Incremental QALYs and YFEOD were larger for males than for females (1.7 vs 1.4 and 1.6 vs 1.3, respectively) favoring ERT as compared with no ERT. The incremental cost per additional YFEOD ranged from €5.9 million to €7.5 million, and the extra costs per additional QALY ranged from €5.5 million to €6.9 million, undiscounted [59]. In the assessment of reporting quality, this study met 22 of the 24 criteria on the CHEERS checklist [27], and 11 of the 17 criteria on the Philips checklist [28].

The Japanese study indicated that migalastat was associated with reduced costs when compared with ERT, from both the public health and the societal perspectives, driven primarily by savings in infusion-related costs [60]. In the base-case analysis (public healthcare payer), the total incremental lifetime cost per patient for ERT versus migalastat was JPY 90,193,830 (€700,846 [based on conversion rate on August 31, 2018; source: xe.com]) (JPY 780,140,002 [€6,062,034] for migalastat versus JPY 870,333,832 [€6 762 880] for ERT). Similarly, from the societal perspective, the total incremental lifetime cost per patient was JPY 94,440,730 (€733,846) (JPY 780,140,002 [€6,062,034] for migalastat vs JPY 874,580,732 [€6,795,880] for ERT). The sensitivity analyses confirmed the robustness of the results of the base-case analysis [60]. In the assessment of reporting quality, this study met 15 of the 24 criteria on the CHEERS checklist [27], and 8 of the 17 criteria on the Philips checklist; unmet criteria may have been attributable to the limitations of reporting in a conference abstract [28].

Cost burden and healthcare resource use associated with FD

Cost burden

Of the 11 studies identified in this section, nine reported cost burden data [40, 61,62,63,64,65,66,67,68]. An overview of the total costs associated with FD management and the contribution of ERT to those costs is presented by country in Table 5. The contribution of oral therapy to the total costs was not evaluated in these studies.

Table 5 Cost burden of FD management and HCRU by country

Overall, all studies that included ERT in a breakdown of overall FD-related expenditure identified ERT as a major contributor to the cost burden associated with FD across different countries [40, 61, 63,64,65], with a contribution of over 95% in some cases. In the Spanish study by Santamaria and colleagues, a majority of costs attributable to ERT was also observed in subgroups defined by lower (< 20) or higher [20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40] Mainz Severity Score Index (MSSI), although the costs were considerably higher in the latter group [61].

Guest and colleagues performed two similar studies—one in Norway and one in Italy—both of which found that the highest annual per-patient costs were expected in the first year after diagnosis for patients not on ERT; for patients receiving ERT, the estimated costs were higher in subsequent years [63, 64]. For patients not on ERT, diagnostic tests were the highest cost driver both in the first year following diagnosis and in subsequent years.

Other types of FD-related costs were reported and included those relating to healthcare and social care use (including visits to healthcare facilities and professionals), dialysis, and tests/procedures (including diagnostic tests). The relationship between time on ERT and healthcare costs was investigated in a study by Wyatt and colleagues [40]. No statistically significant association between time on ERT and total NHS social care cost, hospital care costs, or non-hospital care costs for patients with FD were observed.

Wallace and colleagues did not specifically consider the contribution of ERT to healthcare costs, but looked at overall FD-related expenditure according to presence or absence of CKD [66]. The study reported a 3.5-times higher mean annual cost for patients with CKD compared with patients without CKD (p < 0.01). Mean annual costs for patients with ESRD were 2.5-times higher than those for patients with earlier stages of kidney disease (p < 0.0001).

Healthcare resource use

Seven of the identified studies reported data relating to resource use by patients with FD (Table 5) [40, 61, 63, 64, 66, 69, 70].

In their 2012 study assessing healthcare resource use for patients with FD in the UK, Wyatt and colleagues found that the majority of adult patients used both hospital and non-hospital services; however, among pediatric patients, almost all used non-hospital services, but only 39% used hospital services. A higher proportion of pediatric than adult patients recorded general practitioner visits (including home visits) during the analysis year [40].

In a study by Santamaria and colleagues evaluating annual use of healthcare resources (hospitalization and surgeries, visits to health professionals, diagnostic tests, and treatments) in Spain, 7.14% of patients required admission and 14.3% required surgery related to FD [61]. The most common specialists visited were nephrologists and cardiologists; the most frequently used diagnostic imaging techniques were echocardiography and abdominal ultrasound. This study also calculated a mean (SD) productivity loss (daily and work activities) of 3.28 (7.19) working days/year in patients with FD overall, with the loss increasing with MSSI [61].

The two studies by Guest and colleagues estimated the resource implications of managing adults with FD in Norway and Italy, from the perspectives of the Norwegian publicly funded healthcare system and the Italian Servizio Sanitario Nazionale (SSN) [63, 64]. In an average year in Norway, patients receiving ERT were expected to make an average of 17.2 attendances to their family practitioner’s office for their infusions; in an average year in Italy, patients receiving ERT were expected to make 25.7 hospital attendances to a hospital day ward for infusions [63, 64].

In Germany, Hilz and colleagues quantified the burden of FD on patient productivity and healthcare utilization based on analysis of insurance claims [70]. Most patients received their first diagnosis in outpatient care. Specialists consulted in outpatient care post-index included nephrologists, internal medicine physicians, and ophthalmologists. Almost three-quarters of patients (71%) had at least one hospital stay post-index, while only a fifth of patients had at least one hospital stay pre-index. The number of hospital stays (mean [SD]) was also greater post-index (1.7 [1.7]) compared with pre-index (0.6 [1.4]). The mean duration of sick leave was 17 days post-index and 21 days pre-index [70].

A 2021 study by Wallace and colleagues demonstrated significantly higher healthcare resource utilization (including emergency department visits, physician office visits, outpatient hospital visits, and prescription medications) in patients with FD with versus without CKD [66].

Methodological appraisal of studies reporting cost burden and resource use data

Critical appraisal of cost burden and resource use studies was carried out using the adapted Drummond’s checklist as recommended in the NICE single technology appraisal manufacturer’s template [29, 71]. All 11 studies reported and discussed study results appropriately.

Health utility values in FD

Health state utility values measure preferences that patients attach to specific health-related outcomes, with a scale from 0.0 (death) to 1.0 (perfect health); they are often considered in health economics evaluations. Taken together, data from the seven studies providing utility values for FD (summarized in Table 6) demonstrated no clear effect of sex or age on utility values, but a decrease in utility with increasing number of complications, including cardiac, renal, and cerebrovascular morbidities [35, 40, 45, 47, 48, 59, 72]. Two studies by Arends and colleagues and Nowak and colleagues reported significantly lower utility values in patients with classical disease compared with those with non-classical disease (p = 0.037 [for males at age 50 years] and p < 0.01, respectively) [45, 48]. Furthermore, Arends and colleagues found no change in utility in patients who initiated ERT over a mean follow-up of 6.1 years [45].

Table 6 Utility (A) and disutility (B) values reported in patients with FD

Lloyd and colleagues designed a discrete choice experiment to assess social preference weights for different features of FD treatments in the UK [72]. Participants (n = 506) were significantly more likely to choose a treatment associated with an increase in their life expectancy by 1 year (odds ratio, 1.574; 95% confidence interval CI 1.504–1.647) and significantly less likely to choose a self-administered intravenous treatment compared with an every-other-day tablet (odds ratio, 0.426; 95% CI 0.384–0.474). The estimated disutilities indicated that patients have a preference for an oral tablet over intravenous treatment, in terms of route of administration and avoidance of treatment infusion reactions, and a preference for treatments that are less likely to cause headaches—a potential side effect of some treatments for FD (Table 6).

Discussion and conclusions

In recent years, there has been a shift in the focus of management of FD from treatment to prevention, with the aim of preserving organ function, preserving life expectancy, and optimizing QoL, and with a drive towards earlier diagnosis and management, as supported by consensus recommendations [7, 73,74,75]. Given the variable disease subtypes and relatively small clinical populations for rare diseases such as FD (global prevalence estimated at 1 in 40,000 to 1 in 170,000 [76]), clinical trial research can be challenging and traditional economic models may not be appropriate for evaluating the impact of treatments in these patients [7, 24, 73,74,75]. The aims of the present SLR were, therefore, to provide an update and broad overview of the current humanistic burden of FD (specifically the impact of FD on different measures of patients’ QoL) and of the current economic burden of FD (including healthcare resource utilization and costs). We find that FD still carries a substantial burden, in terms of QoL, healthcare resource use, and costs, indicating a significant unmet need in the management of FD. Moreover, QoL and health utility are impacted by factors such as sex, age, disease severity and complications, and treatment status.

Overall, a clear impact of FD on patients’ QoL was observed across the included studies; lower QoL scores were reported for patients with FD than healthy controls or the general population across multiple QoL domains [19, 30, 31, 33,34,35, 43, 44]. QoL was also influenced by variables such as sex, age, disease severity and manifestations, and treatment status. Generally, lower QoL scores were reported for men with FD than for women with FD [33, 37, 41, 44, 48], and QoL tended to decrease with increasing age [31, 39]. As an X-linked disease, FD is generally viewed as a disorder mainly affecting men; however, reduced QoL was reported for female patients with FD compared with healthy controls or the general population [33, 44], thus highlighting the importance of recognizing the substantial disease burden of FD in both sexes.

Alongside an increase in patient participation in treatment decisions and assessment of their own care, health-related QoL has become an increasingly important measure of treatment efficacy [77, 78]. As such, understanding the impact of disease on patients’ QoL is vital to understanding therapy effectiveness. Here, we found that there is a considerable range of instruments that are used to assess QoL in patients with FD: 25 different types of QoL assessment were identified, and the majority are not specific to FD. This finding highlights the need for standardization in the assessment of QoL in the form of an FD-specific QoL questionnaire. In agreement with Arends and colleagues [4], the findings of the present study indicate that an FD-specific assessment would be valuable for capturing the burden of disease and should include measures that form part of the SF-36 questionnaire, such as physical functioning and health perception, alongside pain, mental health, and sleep. Furthermore, an FD-specific assessment should be applicable or adaptable to both male and female adults with FD, in order to capture the broad and heterogeneous population that may be affected by this disease. Although a tool meeting all of these desired criteria has not yet been established, several recent studies (not captured in the current SLR search) have investigated new FD-specific tools, including: the Fabry Disease Patient-Reported Outcome—Gastrointestinal (FABPRO-GI) for assessing gastrointestinal signs and symptoms; the Fabry Disease—Patient-Reported Outcome (FD-PRO), which covers neuropathic symptoms, headache, abdominal pain, heat intolerance, swelling, tinnitus, fatigue, hearing/vision impairment, hypohidrosis, and difficulty engaging in regular physical activities in the past 24 h; a modified BPI—Short-Form item 3 (BPI-SF3) scale for assessing neuropathic pain specifically in patients with FD; and the Adult Fabry QoL Scale (AFQOL) comprising five domains—neuropathic pain and abdominal symptoms, impact on work and school, relationship challenges, ophthalmologic and otolaryngologic symptoms, and cardiovascular and renal symptoms [79,80,81,82].

Health utility values were typically lower in patients with classical FD than in those with non-classical FD [45, 48]. Moreover, health utility values were influenced by severity of disease and number of complications; utility decreased with increased disease complications [45, 48, 59]. Although age, sex, and ERT status influenced QoL scores, no clear association was reported between these factors and health utility values.

In terms of the economic burden, FD was associated with a high cost and healthcare resource use burden [40, 61, 64, 66, 67]. All studies that included patients who were receiving ERT reported that it made a substantial contribution to the cost of FD management [40, 61, 63,64,65]. In a Japanese study, migalastat was associated with lower costs than ERT, primarily driven by savings in infusion-related costs [60]. It should be noted, however, that migalastat is only indicated in patients with an amenable GLA variant [13]. High healthcare resource utilization was apparent across all studies [40, 61, 63, 64, 66, 69, 70], with higher resource use among patients presenting with renal complications than in those with uncomplicated disease [66].

The cost of ERT should be considered in the context of the impact of treatment status on QoL. Data from registry studies have shown that treatment with ERT attenuates disease progression and reduces the risk of cardiovascular and renal diseases [83]. For instance, Hughes and colleagues demonstrated that prompt treatment with ERT reduces the risk of cardiovascular and renal events in both men and women with FD, and in classical and non-classical disease [84]. Moreover, treatment of younger patients with ERT may be more beneficial than delaying treatment into later adulthood. A study by Parini and colleagues found that, in patients aged under 18 years or 18–30 years who were treated with ERT, renal and cardiac functional decline was attenuated compared with patients who began ERT after the age of 30 [85]. In pediatric patients, ERT was effective in reducing the FD symptoms of pain in girls and gastrointestinal distress in boys, while maintaining stable cardiac and renal parameters [86]. Therefore, the delayed disease progression associated with ERT is likely to benefit patients’ QoL and may also offset some of the healthcare resource use and costs associated with the consequences of disease progression and disease complications, such as hospital visits.

Notwithstanding the clinical benefits of treatment and the expected improvement in patients’ QoL, certain limitations of treatment may also exert an effect on QoL. Limitations of ERT may include the inconvenience of lifelong intravenous infusions, the potential of adverse reactions (fever, chills) in response to infusions, and a potential loss of efficacy due to the production of antidrug neutralizing antibodies. For migalastat, limitations may include the fact that therapy is only an option for patients with amenable GLA mutations, as well as the potential occurrence of adverse events, such as headache [87]. Indeed, Lloyd and colleagues showed that such limitations of treatment are associated with health disutilities, which may influence patient treatment choices to an extent [72]. Consensus statements on the management of FD suggest that therapy-related burdens impacting QoL should be addressed by physicians if possible [74, 88], but studies are needed to further understand the association between the burden of current and emerging FD therapies on patients’ QoL, and these will be critical to better inform disease management.

Few systematic reviews reporting on the burden of FD have been published; here, we provide a comprehensive review, capturing several additional years of studies and combining the humanistic and economic evidence on the overall burden of FD. A systematic review of ERT in FD by Connock and colleagues in 2006 found insufficient data on health utility or economic evaluations to draw robust conclusions on the cost-effectiveness of ERT, likely due to the more limited evidence available at the time of reporting [89]. Similar to the present review, a systematic review by Arends and colleagues in 2015 reported reduced QoL in patients with FD compared with the general population, with renal disease, pain, and age all as influencing factors [4]. However, the economic burden of FD was not reported. A systematic review including an economic evaluation of ERT in FD concluded that FD carries a substantial cost burden, the majority of which can be attributed to treatment with ERT [90], in line with the findings of the present study. However, that review did not explore the humanistic burden of disease.

Although this comprehensive systematic review covered a wide range of QoL tools and various aspects of the economic and resource burden of FD, the findings are subject to some limitations. First, the heterogeneity in populations and measures used across studies, including differences in treatment status, limits the ability to make direct comparisons or to combine results. Second, we did not identify any studies that evaluated the impact of oral chaperone therapy on QoL. Moreover, there are limited data regarding the economic and resource burden of oral therapies. The included studies generally lacked comparison with other disease cohorts—for example, patients with cancer, CKD, heart failure, or type 2 diabetes—and, instead, favored comparisons with aged-matched healthy populations. This limits our ability to interpret these findings on FD in context with other clinical populations. Finally, inherent limitations of SLRs include potential publication bias and potential selection bias within the studies included in the review, particularly in relation to patient recruitment and outcome reporting. The quality of the economic studies included in this SLR was assessed using the CHEERS, Philips, and NICE single technology appraisal-adapted Drummond’s checklists. The included studies met most checklist criteria, suggesting that quality issues of the included studies and potential selection bias within the studies had minimal impact on the interpretation of the SLR results. An additional limitation of the present review is that the quality of the publications on the humanistic burden of disease was not also determined.

In conclusion, there remains a substantial disease burden in patients with FD, indicating an unmet management need. Closer monitoring of QoL with disease-specific instruments and a greater focus on QoL in patient management, as well as increased awareness and adoption of consensus recommendations, may help to address this unmet need. Disease-specific QoL instruments may improve the ability to measure the impact of FD and may provide more specific information on the effect of treatments on different disease phenotypes. The inclusion of key symptoms, such as fatigue, as clinical trial endpoints will also help to establish the impact of treatment on the burden of disease. Furthermore, increased efforts are required to reduce the high healthcare costs associated with FD, which may include utilizing community-based resources as an alternative to hospital visits. As suggested both by Milligan and colleagues and by Beck and colleagues, at-home infusions and self-administration may help to alleviate the burden associated with ERT [91, 92]. Overall, integrating information from QoL and economic assessments may help to identify interventions that are likely to be of most value for specific patient populations, in terms of impact on patients’ QoL and on cost to payers. This could potentially enable better targeting and earlier initiation of treatment, where appropriate, leading to a positive impact on cost-effectiveness in the management of FD.

Availability of data and materials

The data included in this report are from the published literature; all articles meeting the search criteria are listed and full publication details are provided.

Abbreviations

α-Gal A:

α-Galactosidase A

ABCL:

Adult behavior checklist

AFQOL:

Adult Fabry Quality of Life Scale

ASEBA:

Achenbach System of Empirically Based Assessment

ASR:

Adult self-report

BASC:

Behavior Assessment Scale for Children

BDI-II:

Beck Depression Inventory-II

BPI:

Brief Pain Inventory

BPI-SF3:

Brief Pain Inventory – Short-Form item 3

CDI:

Children’s Depression Inventory

CES-D:

Centre of Epidemiologic Studies Depression Scale

CHEERS:

Consolidated Health Economic Evaluation Reporting Standards

CHQ:

Child Health Questionnaire

CI:

Confidence interval

CKD:

Chronic kidney disease

EED:

Economic Evaluations Database

eGFR:

Estimated glomerular filtration rate

EMA:

European Medicines Agency

EQ-5D:

EuroQol five dimension

ERT:

Enzyme replacement therapy

ESRD:

End-stage renal disease

ESS:

Epworth Sleepiness Scale

FABPRO-GI:

Fabry Disease Patient-Reported Outcome – Gastrointestinal

FD:

Fabry disease

FDA:

Food and Drug Administration

FD-PRO:

Fabry Disease – Patient-Reported Outcome

FPHPQ:

Fabry-specific Pediatric Health and Pain Questionnaire

FSS:

Fatigue Severity Scale

Gb3:

Globotriaosylceramide

GL-3:

Globotriaosylceramide

GLA :

α-Galactosidase A gene

HADS:

Hospital Anxiety and Depression Scale

HAM-D:

Hamilton Rating Scale for Depression

HTA:

Health technology assessment

ICER:

Incremental cost-effectiveness ratio

IQR:

Interquartile range

ISPOR:

Professional Society for Health Economics and Outcomes Research

JPY:

Japanese yen

MMSE:

Mini Mental State Examination

MSSI:

Mainz Severity Score Index

NHS:

National Health Service

NICE:

National Institute for Health and Care Excellence

NIHR:

National Institute for Health Research

NRS:

Numerical Rating Scale

NUCOG:

Neuropsychiatric Unit Cognitive Screen

PedsQL:

Pediatric Quality of Life Inventory

PRISMA:

Preferred Reporting Items for Systematic Reviews and Meta-Analysis

PSS-4:

Perceived Stress Scale – 4 items

QALY:

Quality-adjusted life-year

QoL:

Quality of life

RBD:

Rapid eye movement sleep behavior disorder

RBDSQ:

RBD Screening Questionnaire

RRT:

Renal replacement therapy

SD:

Standard deviation

SF-12:

12-Item Short-Form Health Survey

SF-36:

36-Item Short-Form Health Survey

SGA:

Subgroup analysis

SLR:

Systematic literature review

SSIEM:

Society for the Study of Inborn Errors of Metabolism

SSN:

Servizio Sanitario Nazionale

VAS:

Visual analog scale

WHO:

World Health Organization

WHO QoL-100:

100-item World Health Organization Quality of Life scale

WORLD:

We’re Organizing Research on Lysosomal Diseases

YFEOD:

Year free of end-organ damage

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Acknowledgements

Under the direction of the authors, medical writing support was provided by Jessica Hardy, DPhil, of Oxford PharmaGenesis, funded by Takeda Development Center Americas, Inc. The authors would like to acknowledge Astha Jain and Meenu Verma, employees of Parexel, for their contribution to carrying out the systematic literature review.

Funding

The systematic literature review and medical writing support were funded by Takeda Development Center Americas, Inc.

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AJ contributed to the conception of the analysis, development of the protocol, performing the systematic literature review, and the interpretation of the results. EM-H contributed to the conception of the analysis, development of the protocol, and the interpretation of the results. FC and ST contributed to the development of the protocol, performing the systematic literature review, and the interpretation of the results. HH contributed to the conception of the analysis, development of the protocol, performing the systematic literature review, and the interpretation of the results. OA contributed to the conception of the analysis, development of the protocol, performing the systematic literature review, and the interpretation of the results. All authors contributed to drafting the manuscript or to revising it critically for important intellectual content. All authors approved the final version of the manuscript to be published and agree to be accountable for the work.

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Correspondence to Olulade Ayodele.

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Competing interests

AJ has received research grants from Takeda and Amicus and advisory board honoraria and speakers’ fees from Takeda, Sanofi, Amicus and Chiesi. EM-H has received consultancy fees from Takeda and Amicus, and speakers’ fees from Sanofi and Amicus. FC, HH and OA are employees of, and hold stock or stock options in, Takeda. ST is an ex-employee of Parexel. Parexel was commissioned to undertake the systematic literature review.

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Jovanovic, A., Miller-Hodges, E., Castriota, F. et al. A systematic literature review on the health-related quality of life and economic burden of Fabry disease. Orphanet J Rare Dis 19, 181 (2024). https://doi.org/10.1186/s13023-024-03131-y

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