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Ketogenic diet for mitochondrial disease: potential role in treating the Multiple Symmetric Lipomatosis phenotype associated with the common MT-TK genetic mutation
Orphanet Journal of Rare Diseases volume 17, Article number: 12 (2022)
Dear Editor,
We read with appreciation the succinct and informative systematic review by Zweers et al. [1] on the effect of the Ketogenic Diet and/or the Modified Atkins Diet on various mitochondrial disease associated phenotypes.
While this review covered studies pertaining to epilepsy, skeletal and heart muscle, tonus dysregulation, movement disorder, developmental delay/intellectual disability, food intake, weight gain/growth, and hair growth, we note that the multiple symmetric lipomatosis phenotype, frequently associated with the MT-TK genetic mutation, was not covered.
We would like to highlight that a version of the ketogenic diet was employed successfully, along with other simultaneous lifestyle interventions, in treating a disabling multiple symmetric lipomatosis phenotype. This successful intervention was reported in 2020 [2] and warrants further consideration by care providers whose patients are in a similar predicament, and similarly motivated.
Sincerely,
Andre Mattman, MD, FRCPC
Adult Metabolic Diseases Clinic
Vancouver, Canada.
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References
Zweers H, van Wegberg AMJ, Janssen MCH, Wortmann SB. Ketogenic diet for mitochondrial disease: a systematic review on efficacy and safety. Orphanet J Rare Dis. 2021;16(1):295. https://doi.org/10.1186/s13023-021-01927-w (PMID: 34217336).
Nadeau E, Mezei MM, Cresswell M, Zhao S, Bosdet T, Sin DD, Guenette JA, Dupuis I, Allin E, Clarke DC, Mattman A. Self-initiated lifestyle interventions lead to potential insight into an effective, alternative, non-surgical therapy for mitochondrial disease associated multiple symmetric lipomatosis. Mitochondrion. 2020;52:183–9. https://doi.org/10.1016/j.mito.2020.03.009 (Epub 2020 Mar 29 PMID: 32234544).
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Mattman, A., Nadeau, E., Mezei, M.M. et al. Ketogenic diet for mitochondrial disease: potential role in treating the Multiple Symmetric Lipomatosis phenotype associated with the common MT-TK genetic mutation. Orphanet J Rare Dis 17, 12 (2022). https://doi.org/10.1186/s13023-021-02164-x
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DOI: https://doi.org/10.1186/s13023-021-02164-x