Table 2 The symptoms and signs of the patients with AGel amyloidosis in the FIN-GAR phase II registry by order of frequency and the age at the onset of symptoms
Frequency (95% CI) | n | Total | Median age (y) | Interquartile range (y) | |
|---|---|---|---|---|---|
Eyes | |||||
Dry eyes | 93% (90–96) | 242 | 261 | 45 | 37–51 |
Corneal lattice amyloidosis | 89% (85–92) | 231 | 261 | 42 | 34–51 |
Photophobia | 78% (71–86) | 101 | 129 | 49 | 39–61 |
Impaired vision | 78% (73–83) | 204 | 261 | 51 | 41–61 |
Corneal ulcer | 50% (44–56) | 131 | 261 | 49 | 40–60 |
Cataract | 47% (41–53) | 123 | 261 | 62 | 57–68 |
Tearing | 26% (19–34) | 34 | 129 | 56 | 46–62 |
Glaucoma | 23% (18–28) | 60 | 261 | 61 | 51–66 |
Skin and soft tissues | |||||
Drooping eye lids | 86% (82–90) | 225 | 261 | 50 | 42–57 |
Cutis laxa | 84% (79–88) | 219 | 261 | 50 | 42–57 |
Dry skin | 79% (74–84) | 206 | 261 | 40 | 17–54 |
Bruising | 69% (63–75) | 180 | 261 | 39 | 26–47 |
Wounds, skin vulnerability | 64% (55–72) | 82 | 129 | 34 | 15–49 |
Itchy skin | 33% (27–38) | 85 | 261 | 49 | 29–60 |
Varicose veins | 30% (22–38) | 39 | 129 | 36 | 29–47 |
Haemorrhoids | 29% (21–37) | 38 | 129 | 42 | 30–52 |
Hernia of any type | 11% (8–15) | 30 | 261 | 49 | 41–63 |
Prolapse of any type | 8% (5–11) | 21 | 261 | 41 | 32–53 |
Neurology | |||||
Numbness, tingling and other paresthesias | 75% (69–80) | 195 | 261 | 56 | 44–63 |
Facial paresis | 67% (62–73) | 176 | 261 | 50 | 44–59 |
Myokymia | 54% (48–60) | 140 | 261 | 48 | 41–58 |
Carpal tunnel syndrome | 43% (36–49) | 111 | 261 | 50 | 37–61 |
Balance impairement | 39% (33–45) | 103 | 261 | 64 | 55–70 |
Dysarthria | 31% (26–37) | 81 | 261 | 61 | 54–68 |
Kidneys | |||||
Proteinuria | 13% (9–18) | 35 | 261 | 54 | 35–59 |
Renal failure | 5% (3–8) | 14 | 261 | 63 | 61–71 |
Heart | |||||
Arrhytmias | 16% (9–22) | 20 | 129 | 52 | 30–66 |
Ischaemic heart disease | 9% (4–14) | 12 | 129 | 54 | 43–73 |
Cardiomyopathy | 5% (2–8) | 13 | 261 | 58 | 43–65 |
Valvulopathy | 5% (3–8) | 14 | 261 | 61 | 35–73 |
Atrial fibrillation | 5% (1–8) | 6 | 129 | 54 | N/A |
Cardiac failure | 5% (1–8) | 6 | 129 | 61 | 42–74 |
Oral health | |||||
Dry mouth | 43% (36–49) | 111 | 261 | 55 | 41–63 |
Caries | 43% (34–51) | 55 | 129 | 24 | 6–39 |
Gingivitis | 19% (12–26) | 25 | 129 | 54 | 32–59 |
Other symptoms | |||||
Pain | 38% (32–44) | 99 | 261 | ||
Oedema | 28% (22–33) | 72 | 261 | ||
Malignancy | 15% (9–21) | 19 | 129 | ||
Depression | 13% (7–19) | 17 | 129 | ||
Impaired hearing | 43% (37–49) | 112 | 261 | ||
Hypothyreosis | 10% (6–13) | 25 | 261 | ||
Sleep apnoea | 6% (3–9) | 15 | 261 | ||