New insights into pediatric idiopathic pulmonary hemosiderosis: the French RespiRare® cohort
- Jessica Taytard1,
- Nadia Nathan1,
- Jacques de Blic2,
- Mickael Fayon3,
- Ralph Epaud4,
- Antoine Deschildre5,
- Françoise Troussier6,
- Marc Lubrano7,
- Raphaël Chiron8,
- Philippe Reix9,
- Pierrick Cros10,
- Malika Mahloul1,
- Delphine Michon1,
- Annick Clement1,
- Harriet Corvol1Email author and
- for the French RespiRare® group
© Taytard et al.; licensee BioMed Central Ltd. 2013
Received: 12 July 2013
Accepted: 11 October 2013
Published: 14 October 2013
Idiopathic pulmonary hemosiderosis (IPH) is a rare cause of alveolar hemorrhage in children and its pathophysiology remains obscure. Classically, diagnosis is based on a triad including hemoptysis, diffuse parenchymal infiltrates on chest X-rays, and iron-deficiency anemia. We present the French pediatric cohort of IPH collected through the French Reference Center for Rare Lung Diseases (RespiRare®, http://www.respirare.fr).
Since 2008, a national network/web-linked RespiRare® database has been set up in 12 French pediatric respiratory centres. It is structured as a medical recording tool with extended disease-specific datasets containing clinical information relevant to all forms of rare lung diseases including IPH.
We identified 25 reported cases of IPH in children from the database (20 females and 5 males). Among them, 5 presented with Down syndrome. Upon diagnosis, median age was 4.3 [0.8-14.0] yrs, and the main manifestations were: dyspnea (n = 17, 68%), anemia (n = 16, 64%), cough (n = 12, 48%), febrile pneumonia (n = 11, 44%) and hemoptysis (n = 11, 44%). Half of the patients demonstrated diffuse parenchymal infiltrates on chest imaging, and diagnosis was ascertained either by broncho-alveolar lavage indicating the presence of hemosiderin-laden macrophages (19/25 cases), or lung biopsy (6/25). In screened patients, initial auto-immune screening revealed positive antineutrophilic cytoplasmic antibodies (ANCA) (n = 6, 40%), antinuclear antibodies (ANA) (n = 5, 45%) and specific coeliac disease antibodies (n = 4, 28%). All the patients were initially treated by corticosteroids. In 13 cases, immunosuppressants were introduced due to corticoresistance and/or major side effects. Median length of follow-up was 5.5 yrs, with a satisfactory respiratory outcome in 23/25 patients. One patient developed severe pulmonary fibrosis, and another with Down syndrome died as a result of severe pulmonary hemorrhage.
The present cohort provides substantial information on clinical expression and outcomes of pediatric IPH. Analysis of potential contributors supports a role of auto-immunity in disease development and highlights the importance of genetic factors.
KeywordsIdiopathic pulmonary hemosiderosis Child Interstitial lung disease Autoimmune lung disease Coeliac disease Down syndrome
Idiopathic pulmonary hemosiderosis (IPH) is a rare cause of alveolar hemorrhage of unknown etiology in children, leading to chronic infiltrative pulmonary disease [1–4]. It is classically characterized by a triad of hemoptysis, iron-deficiency anemia and pulmonary infiltrates on chest X-rays; and usually occurs before the age of 10 years (yrs) old [5–10]. The diagnosis of IPH is confirmed by bronchoscopy with bronchoalveolar lavage (BAL) showing hemosiderin-laden macrophages called siderophages, pathognomonic of the disease . Lung biopsies are sometimes required to eliminate differential diagnoses such as vasculitis . First line treatments usually include systemic corticosteroid therapy. This may be substituted by immunosuppressants in case of corticosteroid resistance or dependence and/or unfavorable outcome [2, 3, 13, 14].
Various hypotheses have been proposed to explain the pathophysiology of IPH: allergic, environmental, genetic and/or auto-immune. The allergic hypothesis is based on the frequent association between IPH and cow’s milk allergy . The environmental theory has been suggested after the emergence of IPH in children exposed to Stachybotris chartarum[16, 17]. IPH has also been described in siblings, leading to discuss a genetic theory, but no gene has yet been identified [18, 19]. Finally, the auto-immune theory is recognized as the most probable, considering the frequent association with auto-immune diseases such as coeliac disease, glomerulonephritis and/or rheumatoid arthritis [2, 5, 11, 17, 20–23].
Pediatric IPH is a rare respiratory disease whose incidence varies between 0.24 and 1.26 per million . This explains the limited knowledge on physiopathology and the lack of consensus regarding care. Through the organization of the French Reference Center for Rare Lung Diseases (RespiRare®) with the national network/web-linked database (described previously), we reviewed the IPH cases in the French pediatric population with two main goals: to update management strategies and to provide new insights into disease contributors and physiopathology .
Material and methods
Since 2008, the RespiRare® database has been set up in 12 French pediatric respiratory centres. This database is structured as a medical recording tool for the patient, with extended disease-specific datasets containing clinical information relevant to all kinds of rare lung diseases including interstitial lung disease and IPH . The database and the data collection have been approved by French national data protection authorities . Each patient and/or his legal representatives are informed prior to entering their data into the database. This study is a chart based retrospective study. Relevant clinical data of the French pediatric IPH patients were retrospectively collected via the RespiRare® database. Diagnosis is based on the triad of iron deficiency anemia, respiratory symptoms (including dyspnea, cough and hemoptysis), and pulmonary infiltrates on chest imaging, and is confirmed by the presence of hemosiderin laden macrophages in the BAL and/or on lung tissue specimens.
clinical features: age, body mass index (BMI), hemoptysis, dypnea, cough and/or febrile pneumonia; personal and/or familial history of allergy and/or auto-immune diseases;
imaging data: chest X-ray and chest CT scan;
respiratory function tests: spirometry measurements (vital capacity (VC), forced vital capacity (FVC), slow vital capacity (SVC) and forced expiratory volume in one second (FEV1)) and single-breath measure of carbon monoxide diffusion (DLCO);
BAL: the percentage of hemosiderin laden macrophages, and the Golde score. The Golde score is a semi-quantitative method for assessing the hemosiderin content of alveolar macrophages after Prussian blue stain: at least 200 alveolar macrophages are examined and, to each macrophage, is attributed a score ranging from 0 (absence of blue staining) to 4 (hemosiderin laden macrophages); the Golde score represents the mean score on 100 macrophages (that could range from 0 to 400). An alveolar hemorrhage is confirmed for a score higher than 20, and characterized as severe for a score above 100 ;
blood tests: hemoglobin, reticulocytes count, and autoimmune assessments: antitransglutaminase (ATA, IgA and IgG), antigliadin (AGA) and antiendomysium (AEA) antibodies, antinuclear antibodies (ANA), anti-double strand DNA and anti-smooth-muscle antibodies (SMA), rheumatoid factor (RF) and antineutrophilic cytoplasmic antibodies (ANCA).
The data collected during the follow up included treatments, side effects and clinical outcome.
Descriptive data analysis (medians and standard deviations for quantitative values, percentages for qualitative values) have been realised using the Excel 2010 software.
Population demographic description at diagnosis
Main manifestations at diagnosis
Severe anemia (<7 g/dl)
Median age at diagnosis was 4.3 [0.8-14.0] yrs. Diagnosis was made before the age of 2 yrs in 7 patients, and after the age of 10 yrs in 4 of them. Median BMI was 14.75 [13.3-25.5] with a median Z-score of −0.6 [−2.46-2.16]. The main manifestations at diagnosis were: dyspnea (n = 17, 68%), cough (n = 12, 48%), febrile pneumonia (n = 11, 44%) and hemoptysis (n = 11, 44%). Five patients out of the 25 IPH cases had a concomitant Down syndrome (20%).
Among the 25 patients, 2 had a personal history of coeliac disease and one of arthralgia. Five familial cases of autoimmune diseases were observed: 2 ankylosing polyarthritis, 1 coeliac disease, 1 telangiectasis, 1 type 1 diabetes, and one Minkowski-Chauffard disease. Furthermore, 2 patients were dizygote twins and another patient had 2 cousins with an IPH history.
Investigations at diagnosis
Anemia was present in 64% of cases, with a median hemoglobin of 7.2 g/dl [2.3-12.4]. Nine patients had a severe anemia (<7 g/dl). Reticulocytes, documented in only 4 out of the 25 patients, were systematically elevated, varying between 98,900 and 152,150/mm3.
Respiratory function tests
Spirometric analyses at onset were available for 18 patients. The 7 remaining patients had less than 3 yrs old at the time of diagnosis, and, thus, did not perform functional respiratory tests. The spirometric analyses were normal in 9/18 patients (50%), showed a restrictive pattern for 6 patients (37.5%) and an airway obstruction for 1 patient (6%). Medians of VC, FVC and SVC were respectively 69, 70 and 65%. For the patients presenting with a restrictive pattern, the median age was 9 yrs old . DLCO, measured for 9 patients, was either decreased (4/9: 44%), or normal.
The diagnosis was ascertained in 19/25 cases by the BAL that showed an accumulation of hemosiderin-laden macrophages. The Golde score, evaluated in 7 cases indicated a median of 158 [52–356].
Eight patients underwent a lung biopsy, which documented presence of red blood cells in the alveoli and in the interstitium.
Auto immune assessments
Auto-immune assessment at diagnosis
Coeliac disease Ig
Cow's milk allergy
Anti nuclear antibodies
Anti smooth muscle antibodies
Anti ds DNA antibodies
Anti glomerular basal membrane
During the follow-up, additional auto-antibodies were documented: RF (n = 3) and ANA (n = 2). Interestingly, repeated evaluation of the auto-immune status in the 6 positive ANCA patients showed variable evolution: ANCA disappeared for 4 patients at the end of the follow-up, decreased for one patient and remained stable for one patient.
Treatment and follow up
Thirteen patients had an unsatisfactory outcome, including in 6 of them a Cushing syndrome with important gain of weight, stretch marks and hyperthricosis. For these 13 patients, one or more immunosuppressants were added: hydroxychloroquine (4.5 to 6 mg/kg/day for n = 10 patients), mycophenolate mofetil (600 mg/m2/day for n = 7 patients), or azathioprine (1 mg/kg/day for n = 1 patient). No side effects were reported, allowing either to interrupt the corticosteroids (n = 6 patients), or to reduce their dosage (n=7 patients).
The median length of follow-up was 5.5 yrs (2 months to 14 yrs). Respiratory outcome was satisfactory in 23 patients, although 7 of them experienced several relapses. The 2 other patients, who were diagnosed at 5 months old, had a severe expression of the disease: 1 of them developed a pulmonary fibrosis, and the other one (with a Down syndrome) had a fatal pulmonary hemorrhage.
Although several pediatric IPH cases have been reported in the literature, few cohorts have been described so far. To our knowledge, this study is one of the largest ever reported, with 25 IPH pediatric cases, and a long median length of follow-up of 5.5 yrs .
IPH generally occurs in children below the age of 10 yrs, and commonly between the ages of 1–7 yrs [2, 5, 8, 21]. Although the classical triad of iron deficiency anemia, respiratory symptoms (including dyspnea, cough and hemoptysis), and pulmonary infiltrates on chest imaging is characteristic, clinical presentation is highly variable; anemia and dyspnea being the most frequent clinical features (64% and 68% respectively in our study). Hemoptysis only occurred in 50% of the patients, but its incidence could be underestimated in young children, who frequently swallow their sputum. So far, number of studies highlighted an important delay between onset of symptoms and IPH diagnostic, ranging from 1 to 6.3 yrs [3, 7, 11, 14, 21]. In our study, the highest delay reached 16 months. This delay in diagnosis may be due to several factors: insidious onset, and lack of awareness about the condition. Moreover, iron deficiency anemia can also be misleading, especially if respiratory signs are mild.
IPH pathogenesis remains controversial, with, so far, four main etiological hypotheses described in the literature: the environmental, the allergic, the auto-immune, and the genetic hypotheses. In this cohort, we found no evidence favouring an environmental etiology, with, however, little collected information on the various possible environmental factors. This theory was suggested after the occurrence of acute pulmonary hemorrhages in children exposed to Stachybotris chartarum in Cleveland, but was not further confirmed [16, 17]. Similarly, the allergic theory, based on the association with the hypersensitivity to proteins in cow's milk (Heiner syndrome), remains controversial . In the present cohort, 3 patients out of 25 had positive antibodies. As eviction of cow's milk proteins has been shown to benefit the patients with Heiner syndrome, the dosage of cow's milk IgE remains recommended.
Our present study provides support for an auto-immune contribution in IPH physiopathology. First, most of the patients (17 out of the 25) had auto-immune antibodies at onset, and, for 6 patients, additional auto-immune antibodies appeared during the follow-up. The most frequent auto-immune antibodies that were found in our cohort were: SMA (50% of the tested patients); ANA (45%) and ANCA (40%). These antibodies are usually associated with primitive vasculitis and systemic diseases, and rarely reported in IPH patients in the literature [26, 27]. Furthermore, several authors described that one out of 4 children with IPH who survive develops an immune disorder [21, 22]. In their IPH cohort, Le Clainche et al. reported 3 patients out of 15 who displayed rheumatoid arthritis-like symptoms, 6 months to 7 yrs after IPH diagnosis . In our study, the search for RF, performed in 10 patients, gave a positive result in 2 of them. Rheumatoid arthritis is known to be the most frequent systemic disease in the general population (0.5 to 1%) and arthritis is sometimes associated with respiratory symptoms, typically with a diffuse parenchymal lung disease . This would suggest to systematically screen IPH patients for rheumatoid arthritis. Moreover, along with the dosage of RF, we propose to associate the research of anti-citrullinated peptides (anti-CCP). Indeed, several studies have led to suggest that anti-CCPs may be more specific and appear earlier in the course of rheumatoid arthritis than the classical auto-antibodies, even in the absence of clinical manifestations of rheumatoid arthritis or connective tissue disease [28, 29]. Of interest, the levels of anti-CCPs were reported to strongly correlate with the variation in DLCO, and possibly to lung disease severity .
IPH has frequently been associated with the celiac disease, another auto-immune disorder. This association is well-known as the Lane-Hamilton syndrome, with 14 cases described in the literature [31, 32]. In the present study, specific celiac disease anti-bodies (anti-gliadin, anti-endomysium and anti-transglutaminase antibodies) were indeed present in 4 patients among the 14 patients tested (i.e. 28% of the tested patients). As a gluten-free diet has been proven beneficial to the evolution of the celiac disease, as well as to the respiratory outcome of the patients with a Lane-Hamilton syndrome, we recommend a systematic screening for celiac disease in IPH patients. Some authors even suggest to systematically perform gastrointestinal endoscopies and biopsies in IPH patients for whom the severity of anemia is disproportionate to radiological findings, even in the absence of gastrointestinal symptoms [7, 31]. In addition, it may be worth to include HLA screening to the panel of tests performed in IPH situations. Indeed, HLA DQ2 is present in 90 to 95% of the patients presenting with a celiac disease [33, 34].
Information derived from the present cases analysis supports a role of genetic contribution to IPH expression. Two of the patients were dizogote twins, 2 others had relatives with IPH, and 7 had a personal and/or a familial history of auto-immune disorders. An exhaustive research for family history will help developing appropriate genetic studies. We were surprised to find a high prevalence of Down syndromes in our cohort (5 patients out of 25, i.e. 20%), the prevalence of the Down syndrome in the French population being 1/2,000 birth per year. To our knowledge, no study had previously reported such an association, which may provide important insights into IPH physiopathology. Indeed, it is known that Down syndrome patients have more frequent autoimmune diseases, with a particular high frequency of celiac disease [35–38]. In our cohort, among the 4 patients tested positive for celiac disease antibodies, 2 had a Down syndrome. Furthermore, we observed that the Down’s syndrome patients with IPH had a worst prognosis compared to the others, including the patient with a fatal outcome, and the 4 others who experienced frequent relapses. One possible explanation may be the higher frequency of lower respiratory tract infections in Down syndrome patients, possibly linked to lower IgG2 serum levels, lower lymphocytes’ count, and/or lower T and NK lymphocytes counts .
Several therapeutic approaches have been reported in IPH with various results [3, 5, 13]. Disease rarity precludes the set-up of randomized controlled trials to evaluate the efficacy of immunomodulatory and/or anti-inflammatory agents for IPH. As indicated in small case series and/or case reports, the main treatments are corticosteroids with various regimens. Corticosteroids have been reported to be associated with decreased pulmonary bleeding relapses and pulmonary fibrosis progression, as well as with higher survival rates . Therapeutic regimens vary across the studies. Immunosuppressive therapies, mainly azathioprine and hydroxychloroquine, are mostly proposed in situations of patients with steroid-refractory disease [3, 14, 17, 21, 40, 41]. Similar therapeutical strategies were observed in the present cohort, with mainly corticosteroids at diagnosis, then introduction of hydroxychloroquin or mycophenolate mofetil in situations of cortico-dependence and or resistance. In the literature, 2 cases of lung transplantation were reported, but both experienced a recurrence of bleeding within the allograft [40, 41].
The major strengths of the present study are the large size of the cohort, with 25 IPH pediatric cases, and the long follow-up, with a median of 5.5 yrs. The largest pediatric cohort published so far was from India, with 26 children with IPH, but with a shorter length of follow-up (mean: 28 ± 27 months) . These strengths have been achieved thanks to the RespiRare® database, which offers a unique opportunity to collect clinical, biological and radiological data from patients with rare respiratory disorders followed in French pediatric respiratory expert centers. This study has, however, limitations, mainly the heterogeneity in investigation protocols and therapeutic regimens. This is a major challenge that will be efficiently addressed with the set-up of the RespiRare® network and the establishment of common procedures of IPH patient management.
To conclude, the review of this large pediatric cohort leads to suggest a probable concomitant auto-immune and genetic etiology of IPH. This implies that a systematic screening for auto-immune diseases should be included in the diagnostic procedure. An important finding is also the high number of IPH patients with Down syndrome, that will need to be further investigated. Furthermore, a structured follow-up including blood tests with reticulocyte counts is critical to improve patient management and to allow an earlier diagnosis and treatment of exacerbations.
The authors want to thank all members of the RespiRare® centres, the members of the coordination team and the patients’ parents for their involvement and their enthusiasm to create and to lead parents’ associations: Respirer c’est grandir, RespiRare, Belleherbe and A.F.P.I.E.
- Clement A, Nathan N, Epaud R, Fauroux B, Corvol H: Interstitial lung diseases in children. Orphanet J Rare Dis. 2010, 5: 22. 10.1186/1750-1172-5-22.PubMed CentralPubMedView ArticleGoogle Scholar
- Ioachimescu OC, Sieber S, Kotch A: Idiopathic pulmonary haemosiderosis revisited. Eur Respir J. 2004, 24: 162-170. 10.1183/09031936.04.00116302.PubMedView ArticleGoogle Scholar
- Saeed MM, Woo MS, MacLaughlin EF, Margetis MF, Keens TG: Prognosis in pediatric idiopathic pulmonary hemosiderosis. Chest. 1999, 116: 721-725. 10.1378/chest.116.3.721.PubMedView ArticleGoogle Scholar
- Vrielynck S, Mamou-Mani T, Emond S, Scheinmann P, Brunelle F, de Blic J: Diagnostic value of high-resolution CT in the evaluation of chronic infiltrative lung disease in children. AJR Am J Roentgenol. 2008, 191: 914-920. 10.2214/AJR.07.2710.PubMedView ArticleGoogle Scholar
- Bhatia S, Tullu MS, Vaideeswar P, Lahiri KR: Idiopathic pulmonary hemosiderosis: alveoli are an answer to anemia. J Postgrad Med. 2011, 57: 57-60. 10.4103/0022-3859.74290.PubMedView ArticleGoogle Scholar
- Kamienska E, Urasinski T, Gawlikowska-Sroka A, Glura B, Pogorzelski A: Idiopathic pulmonary hemosiderosis in a 9-year-old girl. Eur J Med Res. 2009, 14 (Suppl 4): 112-115.PubMed CentralPubMedGoogle Scholar
- Keskin O, Keskin M, Guler E, Tutar E, Saygili O, Kucukosmanoglu E, Kor Y, Celik H, Coskun E: Unusual presentation: pulmonary hemosiderosis with celiac disease and retinitis pigmentosa in a child. Pediatr Pulmonol. 2011, 46: 820-823. 10.1002/ppul.21420.PubMedView ArticleGoogle Scholar
- Kiper N, Gocmen A, Ozcelik U, Dilber E, Anadol D: Long-term clinical course of patients with idiopathic pulmonary hemosiderosis (1979–1994): prolonged survival with low-dose corticosteroid therapy. Pediatr Pulmonol. 1999, 27: 180-184. 10.1002/(SICI)1099-0496(199903)27:3<180::AID-PPUL5>3.0.CO;2-8.PubMedView ArticleGoogle Scholar
- Pedersen FM, Milman N: Idiopathic pulmonary hemosiderosis. Ugeskr Laeger. 1996, 158: 902-904.PubMedGoogle Scholar
- Poggi V, Lo Vecchio A, Menna F, Menna G: Idiopathic pulmonary hemosiderosis: a rare cause of iron-deficiency anemia in childhood. J Pediatr Hematol Oncol. 2011, 33: e160-e162. 10.1097/MPH.0b013e318212a6df.PubMedView ArticleGoogle Scholar
- Gencer M, Ceylan E, Bitiren M, Koc A: Two sisters with idiopathic pulmonary hemosiderosis. Can Respir J. 2007, 14: 490-493.PubMed CentralPubMedGoogle Scholar
- Godfrey S: Pulmonary hemorrhage/hemoptysis in children. Pediatr Pulmonol. 2004, 37: 476-484. 10.1002/ppul.20020.PubMedView ArticleGoogle Scholar
- Colombo JL, Stolz SM: Treatment of life-threatening primary pulmonary hemosiderosis with Cyclophosphamide. Chest. 1992, 102: 959-960. 10.1378/chest.102.3.959.PubMedView ArticleGoogle Scholar
- Luo XQ, Ke ZY, Huang LB, Guan XQ, Zhang XL, Zhu J, Zhang YC: Maintenance therapy with dose-adjusted 6-mercaptopurine in idiopathic pulmonary hemosiderosis. Pediatr Pulmonol. 2008, 43: 1067-1071. 10.1002/ppul.20894.PubMedView ArticleGoogle Scholar
- Moissidis I, Chaidaroon D, Vichyanond P, Bahna SL: Milk-induced pulmonary disease in infants (heiner syndrome). Pediatr Allergy Immunol. 2005, 16: 545-552. 10.1111/j.1399-3038.2005.00291.x.PubMedView ArticleGoogle Scholar
- Dearborn DG, Smith PG, Dahms BB, Allan TM, Sorenson WG, Montana E, Etzel RA: Clinical profile of 30 infants with acute pulmonary hemorrhage in Cleveland. Pediatrics. 2002, 110: 627-637. 10.1542/peds.110.3.627.PubMedView ArticleGoogle Scholar
- Nuesslein TG, Teig N, Rieger CH: Pulmonary haemosiderosis in infants and children. Paediatr Respir Rev. 2006, 7: 45-48. 10.1016/j.prrv.2005.11.003.PubMedView ArticleGoogle Scholar
- Matsaniotis N, Karpouzas J, Apostolopoulou E, Messaritakis J: Idiopathic pulmonary haemosiderosis in children. Arch Dis Child. 1968, 43: 307-309. 10.1136/adc.43.229.307.PubMed CentralPubMedView ArticleGoogle Scholar
- Beckerman RC, Taussig LM, Pinnas JL: Familial idiopathic pulmonary hemosiderosis. Am J Dis Child. 1979, 133: 609-611.PubMedGoogle Scholar
- Golde DW, Drew WL, Klein HZ, Finley TN, Cline MJ: Occult pulmonary haemorrhage in leukaemia. Br Med J. 1975, 2: 166-168. 10.1136/bmj.2.5964.166.PubMed CentralPubMedView ArticleGoogle Scholar
- Le Clainche L, Le Bourgeois M, Fauroux B, Forenza N, Dommergues JP, Desbois JC, Bellon G, Derelle J, Dutau G, Marguet C, et al: Long-term outcome of idiopathic pulmonary hemosiderosis in children. Medicine (Baltimore). 2000, 79: 318-326. 10.1097/00005792-200009000-00005.View ArticleGoogle Scholar
- Lemley DE, Katz P: Rheumatoid-like arthritis presenting as idiopathic pulmonary hemosiderosis: a report and review of the literature. J Rheumatol. 1986, 13: 954-957.PubMedGoogle Scholar
- Reading R, Watson JG, Platt JW, Bird AG: Pulmonary haemosiderosis and gluten. Arch Dis Child. 1987, 62: 513-515. 10.1136/adc.62.5.513.PubMed CentralPubMedView ArticleGoogle Scholar
- Nathan N, Taam RA, Epaud R, Delacourt C, Deschildre A, Reix P, Chiron R, de Pontbriand U, Brouard J, Fayon M, et al: A national internet-linked based database for pediatric interstitial lung diseases: the French network. Orphanet J Rare Dis. 2012, 7: 40. 10.1186/1750-1172-7-40.PubMed CentralPubMedView ArticleGoogle Scholar
- Kabra SK, Bhargava S, Lodha R, Satyavani A, Walia M: Idiopathic pulmonary hemosiderosis: clinical profile and follow up of 26 children. Indian Pediatr. 2007, 44: 333-338.PubMedGoogle Scholar
- Casian A, Jayne D: Current modalities in the diagnosis of pulmonary vasculitis. Expert Opin Med Diagn. 2012, 6: 499-516. 10.1517/17530059.2012.697895.PubMedView ArticleGoogle Scholar
- Ozen S, Pistorio A, Iusan SM, Bakkaloglu A, Herlin T, Brik R, Buoncompagni A, Lazar C, Bilge I, Uziel Y, et al: EULAR/PRINTO/PRES criteria for henoch-schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood takayasu arteritis: Ankara 2008. Part II: final classification criteria. Ann Rheum Dis. 2010, 69: 798-806. 10.1136/ard.2009.116657.PubMedView ArticleGoogle Scholar
- Nishimura K, Sugiyama D, Kogata Y, Tsuji G, Nakazawa T, Kawano S, Saigo K, Morinobu A, Koshiba M, Kuntz KM, et al: Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med. 2007, 146: 797-808. 10.7326/0003-4819-146-11-200706050-00008.PubMedView ArticleGoogle Scholar
- Fischer A, Solomon JJ, du Bois RM, Deane KD, Olson AL, Fernandez-Perez ER, Huie TJ, Stevens AD, Gill MB, Rabinovitch AM, et al: Lung disease with anti-CCP antibodies but not rheumatoid arthritis or connective tissue disease. Respir Med. 2012, 106: 1040-1047. 10.1016/j.rmed.2012.03.006.PubMed CentralPubMedView ArticleGoogle Scholar
- Wilsher M, Voight L, Milne D, Teh M, Good N, Kolbe J, Williams M, Pui K, Merriman T, Sidhu K, Dalbeth N: Prevalence of airway and parenchymal abnormalities in newly diagnosed rheumatoid arthritis. Respir Med. 2012, 106: 1441-1446. 10.1016/j.rmed.2012.06.020.PubMedView ArticleGoogle Scholar
- Mayes DH, Guerrero ML: A few good men: a marine with hemoptysis and diarrhea. Idiopathic pulmonary hemosiderosis and celiac sprue. Chest. 2008, 134: 644-647. 10.1378/chest.07-2834.PubMedView ArticleGoogle Scholar
- Sethi GR, Singhal KK, Puri AS, Mantan M: Benefit of gluten-free diet in idiopathic pulmonary hemosiderosis in association with celiac disease. Pediatr Pulmonol. 2011, 46: 302-305. 10.1002/ppul.21357.PubMedView ArticleGoogle Scholar
- Admou B, Essaadouni L, Krati K, Zaher K, Sbihi M, Chabaa L, Belaabidia B, Alaoui-Yazidi A: Atypical celiac disease: from recognizing to managing. Gastroenterol Res Pract. 2012, 2012: 637187.PubMed CentralPubMedView ArticleGoogle Scholar
- Nelsen DA: Gluten-sensitive enteropathy (celiac disease): more common than you think. Am Fam Physician. 2002, 66: 2259-2266.PubMedGoogle Scholar
- Chand N, Mihas AA: Celiac disease: current concepts in diagnosis and treatment. J Clin Gastroenterol. 2006, 40: 3-14. 10.1097/01.mcg.0000190644.01661.2b.PubMedView ArticleGoogle Scholar
- Niewinski MM: Advances in celiac disease and gluten-free diet. J Am Diet Assoc. 2008, 108: 661-672. 10.1016/j.jada.2008.01.011.PubMedView ArticleGoogle Scholar
- Nespoli L, Burgio GR, Ugazio AG, Maccario R: Immunological features of Down's syndrome: a review. J Intellect Disabil Res. 1993, 37 (Pt 6): 543-551.PubMedGoogle Scholar
- Pellegrini FP, Marinoni M, Frangione V, Tedeschi A, Gandini V, Ciglia F, Mortara L, Accolla RS, Nespoli L: Down syndrome, autoimmunity and T regulatory cells. Clin Exp Immunol. 2012, 169: 238-243. 10.1111/j.1365-2249.2012.04610.x.PubMed CentralPubMedView ArticleGoogle Scholar
- Broers CJ, Gemke RJ, Weijerman ME, Kuik DJ, van Hoogstraten IM, van Furth AM: Frequency of lower respiratory tract infections in relation to adaptive immunity in children with Down syndrome compared to their healthy siblings. Acta Paediatr. 2012, 101: 862-867. 10.1111/j.1651-2227.2012.02696.x.PubMedView ArticleGoogle Scholar
- Calabrese F, Giacometti C, Rea F, Loy M, Sartori F, Di Vittorio G, Abudureheman A, Thiene G, Valente M: Recurrence of idiopathic pulmonary hemosiderosis in a young adult patient after bilateral single-lung transplantation. Transplantation. 2002, 74: 1643-1645. 10.1097/00007890-200212150-00027.PubMedView ArticleGoogle Scholar
- Wroblewski BM, Stefanovic CR, McDonough VM, Kidik PJ: The challenges of idiopathic pulmonary hemosiderosis and lung transplantation. Crit Care Nurse. 1997, 17: 39-44.PubMedGoogle Scholar
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