Higgs DR, Engel JD, Stamatoyannopoulos G: Thalassaemia. Lancet. 2012, 379: 373-383. 10.1016/S0140-6736(11)60283-3.
CAS
Google Scholar
Viprakasit V, Lee-Lee C, Chong QT, Lin KH, Khuhapinant A: Iron chelation therapy in the management of thalassemia: the Asian perspectives. Int J Hematol. 2009, 90: 435-445. 10.1007/s12185-009-0432-0.
CAS
Google Scholar
Akhtar MS, Qaw F, Borgio JF, Albuali W, Suliman A, Nasserullah Z, Al-Jarrash S, Al-Ali A: Spectrum of alpha-thalassemia mutations in transfusion-dependent beta-thalassemia patients from the Eastern Province of Saudi Arabia. Hemoglobin. 2013, 37: 65-73. 10.3109/03630269.2012.753510.
CAS
Google Scholar
Thalassemia. http://www.cdc.gov/ncbddd/blooddisorders/documents/BBV_PNV_C0_1159_Thalassemia_R2mtr.pdf.
Nienhuis AW, Nathan DG: Pathophysiology and Clinical Manifestations of the beta-Thalassemias. Cold Spring Harb Perspect Med. 2012, 2: a011726. 10.1101/cshperspect.a011726.
PubMed Central
Google Scholar
Cappellini MD, Cohen A, Piga A, Bejaoui M, Perrotta S, Agaoglu L, Aydinok Y, Kattamis A, Kilinc Y, Porter J, Capra M, Galanello R, Fattoum S, Drelichman G, Magnano C, Verissimo M, Athanassiou-Metaxa M, Giardina P, Kourakli-Symeonidis A, Janka-Schaub G, Coates T, Vermylen C, Olivieri N, Thuret I, Opitz H, Ressayre-Djaffer C, Marks P, Alberti D: A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood. 2006, 107: 3455-3462. 10.1182/blood-2005-08-3430.
CAS
Google Scholar
Wood JC, Claster S, Carson S, Menteer JD, Hofstra T, Khanna R, Coates T: Vitamin D deficiency, cardiac iron and cardiac function in thalassaemia major. Br J Haematol. 2008, 141: 891-894. 10.1111/j.1365-2141.2008.07135.x.
CAS
PubMed Central
Google Scholar
Muncie HL, Campbell J: Alpha and beta thalassemia. Am Fam Physician. 2009, 80: 339-344.
Google Scholar
Quek L, Thein SL: Molecular therapies in beta-thalassaemia. Br J Haematol. 2007, 136: 353-365. 10.1111/j.1365-2141.2006.06408.x.
CAS
Google Scholar
Verma IC, Kleanthous M, Saxena R, Fucharoen S, Winichagoon P, Raizuddin S, Khan SN, Akbari MT, Izadyar M, Kotea N, Old JM, Ioannou PA, Khan B: Multicenter study of the molecular basis of thalassemia intermedia in different ethnic populations. Hemoglobin. 2007, 31: 439-452. 10.1080/03630260701641245.
CAS
Google Scholar
Alamiry AAN, Ali TH, Majeed MN: Detection of Hemoglobinopathies in Hypochromic, Microcytic and Sickeled Cell Blood Films by Hemoglobin Electrophoresis. Thi-Qar Med J. 2011, 5: 139-148.
Google Scholar
Al-Sulaiman A: Prevalence of β-thalassemia trait in premarital screening in Al-Hassa, Saudi Arabia. Ann Saudi Med. 2006, 26: 14-16.
Google Scholar
Nadkarni KV, Al-Arrayed SS, Bapat JP: Incidence of Genetic Disorders of Hemoglobins in the Hospital Population of Bahrain. Bahrain Med Bull. 1991, 13.
Google Scholar
Fawzi ZO, Al Hilali A, Fakhroo N, Al Bin Ali A, Al Mansour S: Distribution of Hemoglobinopathies and Thalassemias in Qatari Nationals Seen at Hamad Hospital in Qatar. Qatar Med J. 2003, 12.
Google Scholar
White JM, Byrne M, Richards R, Buchanan T, Katsoulis E, Weerasingh K: Red cell genetic abnormalities in Peninsular Arabs: sickle haemoglobin, G6PD deficiency, and alpha and beta thalassaemia. J Med Genet. 1986, 23: 245-251. 10.1136/jmg.23.3.245.
CAS
PubMed Central
Google Scholar
Rajab AG, Patton MA, Modell B: Study of hemoglobinopathies in Oman through a national register. Saudi Med J. 2000, 21: 1168-1172.
CAS
Google Scholar
Al-Riyami A, Ebrahim GJ: Genetic Blood Disorders Survey in the Sultanate of Oman. J Trop Pediatr. 2003, 49 (Suppl 1): i1-20.
Google Scholar
Al-Sultan A, Phanasgaonkar S, Suliman A, Al-Baqushi M, Nasrullah Z, Al-Ali A: Spectrum of beta-thalassemia mutations in the eastern province of Saudi Arabia. Hemoglobin. 2011, 35: 125-134. 10.3109/03630269.2011.553567.
CAS
Google Scholar
Pembrey ME, Perrine RP, Wood WG, Weatherall DJ: Sickle beta 0 thalassemia in Eastern Saudi Arabia. Am J Hum Genet. 1980, 32: 26-41.
CAS
PubMed Central
Google Scholar
Flint J, Harding RM, Boyce AJ, Clegg JB: The population genetics of the haemoglobinopathies. Baillieres Clin Haematol. 1998, 11: 1-51. 10.1016/S0950-3536(98)80069-3.
CAS
Google Scholar
Zahed L: The Spectrum of beta-Thalassemia Mutations in the Arab Populations. J Biomed Biotechnol. 2001, 1: 129-132. 10.1155/S1110724301000298.
CAS
PubMed Central
Google Scholar
El-Hazmi MA, Warsy AS, Al-Swailem AR: The frequency of 14 beta-thalassemia mutations in the Arab populations. Hemoglobin. 1995, 19: 353-360. 10.3109/03630269509005827.
CAS
Google Scholar
Baysal E: Molecular heterogeneity of beta-thalassemia in the United Arab Emirates. Community Genet. 2005, 8: 35-39. 10.1159/000083336.
CAS
Google Scholar
Aydinok Y: Thalassemia. Hematology. 2012, 17 (Suppl 1): S28-31.
CAS
Google Scholar
Tassiopoulos T, Rombos Y, Konstantopoulos K, Revenas K, Tassiopoulos S, Aessopos A: Spleen size in beta-thalassaemia heterozygotes. Haematologia (Budap). 1995, 26: 205-209.
CAS
Google Scholar
Karimi M, Bagheri MH, Tahmtan M, Shakibafard A, Rashid M: Prevalence of hepatosplenomegaly in beta thalassemia minor subjects in Iran. Eur J Radiol. 2009, 69: 120-122. 10.1016/j.ejrad.2007.09.027.
Google Scholar
Olivieri NF: The beta-thalassemias. N Engl J Med. 1999, 341: 99-109. 10.1056/NEJM199907083410207.
CAS
Google Scholar
Aessopos A, Farmakis D, Karagiorga M, Voskaridou E, Loutradi A, Hatziliami A, Joussef J, Rombos J, Loukopoulos D: Cardiac involvement in thalassemia intermedia: a multicenter study. Blood. 2001, 97: 3411-3416. 10.1182/blood.V97.11.3411.
CAS
Google Scholar
Taher AT, Musallam KM, El-Beshlawy A, Karimi M, Daar S, Belhoul K, Saned MS, Graziadei G, Cappellini MD: Age-related complications in treatment-naive patients with thalassaemia intermedia. Br J Haematol. 2010, 150: 486-489.
Google Scholar
Forget B: Thalassemia Syndromes. Hematology: Basic Principles and Practice. 3 edition. Edited by: Hoffman R, Benz EJ, Shattil S, Furie B, Cohen H, Silberstein L, McGlave P. New York: Churchill Livingstone; 2000.
Google Scholar
Galanello R, Origa R: Beta-thalassemia. Orphanet J Rare Dis. 2010, 5: 11. 10.1186/1750-1172-5-11.
PubMed Central
Google Scholar
Cao A, Galanello R: Beta-thalassemia. Genet Med. 2010, 12: 61-76. 10.1097/GIM.0b013e3181cd68ed.
CAS
Google Scholar
Cappellini MD, Musallam KM, Taher AT: Insight onto the pathophysiology and clinical complications of thalassemia intermedia. Hemoglobin. 2009, 33 (Suppl 1): S145-159.
CAS
Google Scholar
Daar S, Gravell D, Hussein HM, Pathare AV, Wali Y, Krishnamoorthy R: Haematological and clinical features of beta-thalassaemia associated with Hb Dhofar. Eur J Haematol. 2008, 80: 67-70.
CAS
Google Scholar
Tony S, Daar S, Elshinawy M, Al-Zadjaly S, Al-Khabori M, Wali Y: T2* MRI in regularly transfused children with thalassemia intermedia: serum ferritin does not reflect liver iron stores. Pediatr Hematol Oncol. 2012, 29: 579-584. 10.3109/08880018.2012.708891.
CAS
Google Scholar
Bunn H, Forget B: Hemoglobin: Molecular, Genetic and Clinical Aspects.Philadelphia: W B Saunders Co; 1986.
Google Scholar
Weatherall D: The Thalessemias. Molecular Basis of Blood Diseases. 2 edition. Edited by: Stamatoyannopoulos G, Nienhuis A, Majerus P. Philadelphia: W B Saunders Co; 1994.
Google Scholar
Adams JG, Coleman MB: Structural hemoglobin variants that produce the phenotype of thalassemia. Semin Hematol. 1990, 27: 229-238.
CAS
Google Scholar
Forget B, Pearson H: Hemoglobin Synthesis and the Thalassemias. Blood: Principles and Practice of Hematology. Edited by: Handin R, Lux S, Stoesel T. Philadelphia: JB Lippincott; 1995.
Google Scholar
Schwartz E, Benx E: Thalassemia Syndromes. Smith's Blood Diseases of Infancy and Childhood. Edited by: Miller D, Baehner R. St Louis: CV Mosby; 1989: 428-6.
Google Scholar
Vento S, Cainelli F, Cesario F: Infections and thalassaemia. Lancet Infect Dis. 2006, 6: 226-233. 10.1016/S1473-3099(06)70437-6.
Google Scholar
Rahav G, Volach V, Shapiro M, Rund D, Rachmilewitz EA, Goldfarb A: Severe infections in thalassaemic patients: prevalence and predisposing factors. Br J Haematol. 2006, 133: 667-674. 10.1111/j.1365-2141.2006.06082.x.
Google Scholar
Vichinsky EP: The morbidity of bone disease in thalassemia. Ann N Y Acad Sci. 1998, 850: 344-348. 10.1111/j.1749-6632.1998.tb10491.x.
CAS
Google Scholar
Voskaridou E, Terpos E, Spina G, Palermos J, Rahemtulla A, Loutradi A, Loukopoulos D: Pamidronate is an effective treatment for osteoporosis in patients with beta-thalassaemia. Br J Haematol. 2003, 123: 730-737. 10.1046/j.1365-2141.2003.04657.x.
CAS
Google Scholar
Farmaki K, Angelopoulos N, Anagnostopoulos G, Gotsis E, Rombopoulos G, Tolis G: Effect of enhanced iron chelation therapy on glucose metabolism in patients with beta-thalassaemia major. Br J Haematol. 2006, 134: 438-444. 10.1111/j.1365-2141.2006.06203.x.
CAS
Google Scholar
Cunningham M, Sankaran V, Nathan D, Orkin S: The Thalassemias. In Nathan And Oski’s Hematology Of Infancy And Childhood. 7th edition. Philadelphia: Saunders Elsevier; 2009.
Google Scholar
British Committee for Standards in Haematology Blood Transfusion Task Force: The administration of blood and blood components and the management of transfused patients. British Committee for Standards in Haematology, Blood Transfusion Task Force. Royal College of Nursing and the Royal College of Surgeons of England. Transfus Med. 1999, 9: 227-238. 10.1046/j.1365-3148.1999.00203.x.
Google Scholar
Swanson K, Dwyre DM, Krochmal J, Raife TJ: Transfusion-related acute lung injury (TRALI): current clinical and pathophysiologic considerations. Lung. 2006, 184: 177-185. 10.1007/s00408-005-2578-8.
Google Scholar
Cazzola M, De Stefano P, Ponchio L, Locatelli F, Beguin Y, Dessi C, Barella S, Cao A, Galanello R: Relationship between transfusion regimen and suppression of erythropoiesis in beta-thalassaemia major. Br J Haematol. 1995, 89: 473-478. 10.1111/j.1365-2141.1995.tb08351.x.
CAS
Google Scholar
Royal College of Physicians of Edinburgh: Consensus statement on red cell transfusion. Transfus Med. 1994, 4: 177-178.
Google Scholar
Goodnough LT, Brecher ME, Kanter MH, AuBuchon JP: Transfusion medicine. First of two parts–blood transfusion. N Engl J Med. 1999, 340: 438-447. 10.1056/NEJM199902113400606.
CAS
Google Scholar
Borgna-Pignatti C, Rugolotto S, De Stefano P, Zhao H, Cappellini MD, Del Vecchio GC, Romeo MA, Forni GL, Gamberini MR, Ghilardi R, Piga A, Cnaan A: Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica. 2004, 89: 1187-1193.
Google Scholar
Modell B, Khan M, Darlison M: Survival in beta-thalassaemia major in the UK: data from the UK Thalassaemia Register. Lancet. 2000, 355: 2051-2052. 10.1016/S0140-6736(00)02357-6.
CAS
Google Scholar
Evangeli M, Mughal K, Porter JB: Which psychosocial factors are related to chelation adherence in thalassemia? A systematic review. Hemoglobin. 2010, 34: 305-321. 10.3109/03630269.2010.485080.
CAS
Google Scholar
Andrews NC: Disorders of iron metabolism. N Engl J Med. 1999, 341: 1986-1995. 10.1056/NEJM199912233412607.
CAS
Google Scholar
Gardenghi S, Marongiu MF, Ramos P, Guy E, Breda L, Chadburn A, Liu Y, Amariglio N, Rechavi G, Rachmilewitz EA, Breuer W, Cabantchik ZI, Wrighting DM, Andrews NC, de Sousa M, Giardina PJ, Grady RW, Rivella S: Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. Blood. 2007, 109: 5027-5035. 10.1182/blood-2006-09-048868.
CAS
PubMed Central
Google Scholar
Kohgo Y, Ikuta K, Ohtake T, Torimoto Y, Kato J: Body iron metabolism and pathophysiology of iron overload. Int J Hematol. 2008, 88: 7-15. 10.1007/s12185-008-0120-5.
CAS
PubMed Central
Google Scholar
Olivieri NF, Brittenham GM: Iron-chelating therapy and the treatment of thalassemia. Blood. 1997, 89: 739-761.
CAS
Google Scholar
Morrison ED, Brandhagen DJ, Phatak PD, Barton JC, Krawitt EL, El-Serag HB, Gordon SC, Galan MV, Tung BY, Ioannou GN, Kowdley KV: Serum ferritin level predicts advanced hepatic fibrosis among U.S. patients with phenotypic hemochromatosis. Ann Intern Med. 2003, 138: 627-633. 10.7326/0003-4819-138-8-200304150-00008.
CAS
Google Scholar
Angelucci E, Brittenham GM, McLaren CE, Ripalti M, Baronciani D, Giardini C, Galimberti M, Polchi P, Lucarelli G: Hepatic iron concentration and total body iron stores in thalassemia major. N Engl J Med. 2000, 343: 327-331. 10.1056/NEJM200008033430503.
CAS
Google Scholar
St Pierre TG, Clark PR, Chua-anusorn W, Fleming AJ, Jeffrey GP, Olynyk JK, Pootrakul P, Robins E, Lindeman R: Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood. 2005, 105: 855-861. 10.1182/blood-2004-01-0177.
CAS
Google Scholar
Anderson LJ, Holden S, Davis B, Prescott E, Charrier CC, Bunce NH, Firmin DN, Wonke B, Porter J, Walker JM, Pennell DJ: Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J. 2001, 22: 2171-2179. 10.1053/euhj.2001.2822.
CAS
Google Scholar
Elalfy M, Shebl S, Badr M, Elsafy U, Salama M, Al-Tonbary Y, Abdel Rahman Y, Qari M, Al Damnhouri G, Al Hawsawi Z, Wali Y, Yesilipek M, Kilinc Y, Yazman D, Karakas Z, Tricta F: Frequency of Agranulocytosis and Mild Neutropenia During Deferiprone Therapy in Clinical Practice. ASH Annual Meeting. 2012, 120: 996.
Google Scholar
Vermylen C: What is new in iron overload?. Eur J Pediatr. 2008, 167: 377-381. 10.1007/s00431-007-0604-y.
PubMed Central
Google Scholar
Uygun V, Kurtoglu E: Iron-chelation therapy with oral chelators in patients with thalassemia major. Hematology. 2013, 18: 50-55. 10.1179/1607845412Y.0000000046.
CAS
Google Scholar
Lucarelli G, Galimberti M, Polchi P, Angelucci E, Baronciani D, Giardini C, Politi P, Durazzi SM, Muretto P, Albertini F: Bone marrow transplantation in patients with thalassemia. N Engl J Med. 1990, 322: 417-421. 10.1056/NEJM199002153220701.
CAS
Google Scholar
Lucarelli G, Galimberti M, Polchi P, Angelucci E, Baronciani D, Giardini C, Andreani M, Agostinelli F, Albertini F, Clift RA: Marrow transplantation in patients with thalassemia responsive to iron chelation therapy. N Engl J Med. 1993, 329: 840-844. 10.1056/NEJM199309163291204.
CAS
Google Scholar
Sodani P, Gaziev D, Polchi P, Erer B, Giardini C, Angelucci E, Baronciani D, Andreani M, Manna M, Nesci S, Lucarelli B, Clift RA, Lucarelli G: New approach for bone marrow transplantation in patients with class 3 thalassemia aged younger than 17 years. Blood. 2004, 104: 1201-1203. 10.1182/blood-2003-08-2800.
CAS
Google Scholar
Al-Jefri A, Ayas A, Al Musa A, Al Mahr M, Al Saleh M, Rifai S, Sabbah R, Al Seraihy A, Al Ahmari A, Khairy E, Al Hassan I, El Solh H: Allogeneic stem cell transplantation in patients with beta-thalassemia: King Faisal Specialist Hospital and Research Centre Experience. Hemoglobin. 2009, 33 (Suppl 1): S183-187.
CAS
Google Scholar
Smiers FJ, Krishnamurti L, Lucarelli G: Hematopoietic stem cell transplantation for hemoglobinopathies: current practice and emerging trends. Pediatr Clin North Am. 2010, 57: 181-205. 10.1016/j.pcl.2010.01.003.
Google Scholar
Al Jefri AH: Advances in allogeneic stem cell transplantation for hemoglobinopathies. Hemoglobin. 2011, 35: 469-475. 10.3109/03630269.2011.618567.
CAS
Google Scholar
Gaziev J, Sodani P, Lucarelli G, Polchi P, Marktel S, Paciaroni K, Marziali M, Isgro A, Simone MD, Roveda A, Montuoro A, Lanti A, Alfieri C, De Angelis G, Gallucci C, Ciceri F, Roncarolo MG: Second hematopoietic SCT in patients with thalassemia recurrence following rejection of the first graft. Bone Marrow Transplant. 2008, 42: 397-404. 10.1038/bmt.2008.175.
CAS
Google Scholar
Lucarelli G, Gaziev J: Advances in the allogeneic transplantation for thalassemia. Blood Rev. 2008, 22: 53-63. 10.1016/j.blre.2007.10.001.
Google Scholar
Bernardo ME, Piras E, Vacca A, Giorgiani G, Zecca M, Bertaina A, Pagliara D, Contoli B, Pinto RM, Caocci G, Mastronuzzi A, La Nasa G, Locatelli F: Allogeneic hematopoietic stem cell transplantation in thalassemia major: results of a reduced-toxicity conditioning regimen based on the use of treosulfan. Blood. 2012, 120: 473-476. 10.1182/blood-2012-04-423822.
CAS
Google Scholar
Li C, Wu X, Feng X, He Y, Liu H, Pei F, Liao J, He L, Shi L, Li N, Liu Q, Liu S, Chen G, Su Q, Ren Y, Wang Y, Tan W: A novel conditioning regimen improves outcomes in beta-thalassemia major patients using unrelated donor peripheral blood stem cell transplantation. Blood. 2012, 120: 3875-3881. 10.1182/blood-2012-03-417998.
CAS
Google Scholar
Locatelli F, Rocha V, Reed W, Bernaudin F, Ertem M, Grafakos S, Brichard B, Li X, Nagler A, Giorgiani G, Haut PR, Brochstein JA, Nugent DJ, Blatt J, Woodard P, Kurtzberg J, Rubin CM, Miniero R, Lutz P, Raja T, Roberts I, Will AM, Yaniv I, Vermylen C, Tannoia N, Garnier F, Ionescu I, Walters MC, Lubin BH, Gluckman E: Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease. Blood. 2003, 101: 2137-2143. 10.1182/blood-2002-07-2090.
CAS
Google Scholar
Alkindi S, Dennison D: Umbilical Cord Blood Banking and Transplantation: A short review. Sultan Qaboos Univ Med J. 2011, 11: 455-461.
PubMed Central
Google Scholar
Cianciulli P: Treatment of iron overload in thalassemia. Pediatr Endocrinol Rev. 2008, 6 (Suppl 1): 208-213.
Google Scholar
De Sanctis V: Growth and puberty and its management in thalassaemia. Horm Res. 2002, 58 (Suppl 1): 72-79.
CAS
Google Scholar
Low LC: Growth, puberty and endocrine function in beta-thalassaemia major. J Pediatr Endocrinol Metab. 1997, 10: 175-184.
CAS
Google Scholar
Wonke B: Bone disease in beta-thalassaemia major. Br J Haematol. 1998, 103: 897-901. 10.1046/j.1365-2141.1998.01107.x.
CAS
Google Scholar
Perera NJ, Lau NS, Mathews S, Waite C, Ho PJ, Caterson ID: Overview of endocrinopathies associated with beta-thalassaemia major. Intern Med J. 2010, 40: 689-696. 10.1111/j.1445-5994.2010.02254.x.
CAS
Google Scholar
Raiola G, Galati MC, De Sanctis V, Caruso Nicoletti M, Pintor C, De Simone M, Arcuri VM, Anastasi S: Growth and puberty in thalassemia major. J Pediatr Endocrinol Metab. 2003, 16 (Suppl 2): 259-266.
Google Scholar
Chatterjee R, Bajoria R: Osteopenia-osteoporosis syndrome in patients with thalassemia: understanding of type of bone disease and response to treatment. Hemoglobin. 2009, 33 (Suppl 1): S136-138.
CAS
Google Scholar
De Sanctis V, Skordis N, Galati MC, Raiola G, Giovannini M, Candini G, Kaffe K, Savvides I, Christou S: Growth hormone and adrenal response to intramuscular glucagon test and its relationship to IGF-1 production and left ventricular ejection fraction in adult B-thalassemia major patients. Pediatr Endocrinol Rev. 2011, 8 (Suppl 2): 290-294.
Google Scholar
Bajoria R, Chatterjee R: Hypogonadotrophic hypogonadism and diminished gonadal reserve accounts for dysfunctional gametogenesis in thalassaemia patients with iron overload presenting with infertility. Hemoglobin. 2011, 35: 636-642. 10.3109/03630269.2011.623809.
CAS
Google Scholar
Merchant RH, Shirodkar A, Ahmed J: Evaluation of growth, puberty and endocrine dysfunctions in relation to iron overload in multi transfused Indian thalassemia patients. Indian J Pediatr. 2011, 78: 679-683. 10.1007/s12098-010-0351-3.
Google Scholar
Chatterjee R, Mukhopadhyay TN, Chandra S, Bajoria R: Sex steroid priming for induction of puberty in thalassemia patients with pulsatile reversible hypogonadotrophic hypogonadism. Hemoglobin. 2011, 35: 659-664. 10.3109/03630269.2011.630121.
CAS
Google Scholar
Eldor A, Rachmilewitz EA: The hypercoagulable state in thalassemia. Blood. 2002, 99: 36-43. 10.1182/blood.V99.1.36.
CAS
Google Scholar
Barnett CF, Hsue PY, Machado RF: Pulmonary hypertension: an increasingly recognized complication of hereditary hemolytic anemias and HIV infection. JAMA. 2008, 299: 324-331. 10.1001/jama.299.3.324.
CAS
Google Scholar
Rasekhi AR, Naderifar M, Bagheri MH, Shahriari M, Foroutan H, Karimi M, Nabavizadeh SA: Radiofrequency ablation of the spleen in patients with thalassemia intermedia: a pilot study. Am J Roentgenol. 2009, 192: 1425-1429. 10.2214/AJR.08.1382.
CAS
Google Scholar
Machado NO, Grant CS, Alkindi S, Daar S, Al-Kindy N, Al Lamki Z, Ganguly SS: Splenectomy for haematological disorders: a single center study in 150 patients from Oman. Int J Surg. 2009, 7: 476-481. 10.1016/j.ijsu.2009.08.004.
Google Scholar
ACOG Committee: ACOG Practice Bulletin. Clinical Management Guidelines for Obstetrician-Gynecologists Number 64, July 2005 (Replaces Committee Opinion Number 238, July 2000): hemoglobinpathies in pregnancy. Obstetrics and Gynecology. 2005, 106: 203-210. 10.1097/00006250-200507000-00052.
Google Scholar
Cogliandro T, Derchi G, Mancuso L, Mayer MC, Pannone B, Pepe A, Pili M, Bina P, Cianciulli P, De Sanctis V, Maggio A: Society for the Study of T, Hemoglobinopathies: Guideline recommendations for heart complications in thalassemia major. J Cardiovasc Med (Hagerstown). 2008, 9: 515-525. 10.2459/JCM.0b013e3282f20847.
Google Scholar
Origa R, Piga A, Quarta G, Forni GL, Longo F, Melpignano A, Galanello R: Pregnancy and beta-thalassemia: an Italian multicenter experience. Haematologica. 2010, 95: 376-381. 10.3324/haematol.2009.012393.
PubMed Central
Google Scholar
Exjade product monograph USA. 2011,http://www.drugs.com/monograph/exjade.html.
Ferriprox product monograph.http://www.drugs.com/monograph/deferiprone.html.
Deugnier Y, Turlin B, Ropert M, Cappellini MD, Porter JB, Giannone V, Zhang Y, Griffel L, Brissot P: Improvement in liver pathology of patients with beta-thalassemia treated with deferasirox for at least 3 years. Gastroenterology. 2011, 141: e1201-1203. 1202–1211, 1211.
Google Scholar
Patel H, Qari M, Mousa S: Iron Balance in β-thalassemia: Maintaining an Oxidant/Antioxidant Ratio. J App Hematol. 2012, 3: 4-11.
Google Scholar
Cappellini M-D, Cohen A, Eleftheriou A, Piga A, Porter J, Taher A: Guidelines for the clinical management of thalassemia. 2 edition. Nicosia, Cyprus: Thalassemia International Federation; 2008.
Google Scholar
Mahachoklertwattana P, Sirikulchayanonta V, Chuansumrit A, Karnsombat P, Choubtum L, Sriphrapradang A, Domrongkitchaiporn S, Sirisriro R, Rajatanavin R: Bone histomorphometry in children and adolescents with beta-thalassemia disease: iron-associated focal osteomalacia. J Clin Endocrinol Metab. 2003, 88: 3966-3972. 10.1210/jc.2002-021548.
CAS
Google Scholar
Tsay J, Yang Z, Ross FP, Cunningham-Rundles S, Lin H, Coleman R, Mayer-Kuckuk P, Doty SB, Grady RW, Giardina PJ, Boskey AL, Vogiatzi MG: Bone loss caused by iron overload in a murine model: importance of oxidative stress. Blood. 2010, 116: 2582-2589. 10.1182/blood-2009-12-260083.
CAS
PubMed Central
Google Scholar
Lasco A, Morabito N, Gaudio A, Buemi M, Wasniewska M, Frisina N: Effects of hormonal replacement therapy on bone metabolism in young adults with beta-thalassemia major. Osteoporos Int. 2001, 12: 570-575. 10.1007/s001980170079.
CAS
Google Scholar
Taksande A, Prabhu S, Venkatesh S: Cardiovascular aspect of Beta-thalassaemia. Cardiovasc Hematol Agents Med Chem. 2012, 10: 25-30. 10.2174/187152512799201172.
CAS
Google Scholar
Borgna Pignatti C, Carnelli V, Caruso V, Dore F, De Mattia D, Di Palma A, Di Gregorio F, Romeo MA, Longhi R, Mangiagli A, Melevendi C, Pizzarelli G, Musumeci S: Thromboembolic events in beta thalassemia major: an Italian multicenter study. Acta Haematol. 1998, 99: 76-79. 10.1159/000040814.
CAS
Google Scholar
Cogliandro T, Derchi G, Mancuso L, Mayer MC, Pannone B, Pepe A, Pili M, Bina P, Cianciulli P, De Sanctis V, Maggio A: Guideline recommendations for heart complications in thalassemia major. J Cardiovasc Med (Hagerstown). 2008, 9: 515-525. 10.2459/JCM.0b013e3282f20847.
Google Scholar
Maggio A, Filosa A, Vitrano A, Aloj G, Kattamis A, Ceci A, Fucharoen S, Cianciulli P, Grady RW, Prossomariti L, Porter JB, Iacono A, Cappellini MD, Bonifazi F, Cassara F, Harmatz P, Wood J, Gluud C: Iron chelation therapy in thalassemia major: a systematic review with meta-analyses of 1520 patients included on randomized clinical trials. Blood Cells Mol Dis. 2011, 47: 166-175. 10.1016/j.bcmd.2011.07.002.
CAS
Google Scholar
Modell B, Khan M, Darlison M, Westwood MA, Ingram D, Pennell DJ: Improved survival of thalassaemia major in the UK and relation to T2* cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2008, 10: 42-10.1186/1532-429X-10-42.
PubMed Central
Google Scholar
Bourli E, Dimitriadou M, Economou M, Vlachaki E, Christoforidis A, Maratou E, Stanopoulos I, Argyropoulou P, Aivazis V: Restrictive pulmonary dysfunction and its predictors in young patients with beta-thalassaemia major. Pediatr Pulmonol. 2012, 47: 801-807. 10.1002/ppul.22506.
Google Scholar
Morris CR, Vichinsky EP: Pulmonary hypertension in thalassemia. Ann N Y Acad Sci. 2010, 1202: 205-213. 10.1111/j.1749-6632.2010.05580.x.
CAS
Google Scholar
Chueamuangphan N, Wongtheptien W, Nawarawong W, Sukornthasarn A, Chuncharunee S, Tawichasri C, Patumanond J: Clinical indicators for pulmonary arterial hypertension in thalassemia. J Med Assoc Thai. 2012, 95: 16-21.
Google Scholar
Aydinok Y, Erermis S, Bukusoglu N, Yilmaz D, Solak U: Psychosocial implications of Thalassemia Major. Pediatr Int. 2005, 47: 84-89. 10.1111/j.1442-200x.2004.02009.x.
Google Scholar
Aydin B, Yaprak I, Akarsu D, Okten N, Ulgen M: Psychosocial aspects and psychiatric disorders in children with thalassemia major. Acta Paediatr Jpn. 1997, 39: 354-357. 10.1111/j.1442-200X.1997.tb03752.x.
CAS
Google Scholar
Pakbaz Z, Treadwell M, Yamashita R, Quirolo K, Foote D, Quill L, Singer T, Vichinsky EP: Quality of life in patients with thalassemia intermedia compared to thalassemia major. Ann N Y Acad Sci. 2005, 1054: 457-461. 10.1196/annals.1345.059.
Google Scholar
Guideline: Alternative approaches to the treatment of thalassemia. http://www.ithanet.eu/ithapedia/index.php/Guideline:Alternative_approaches_to_the_treatment_of_thalassemia.
Wang H: Prediction, validation and targeted interference of erythroid regulatory modules. Dissertation. University Park, PA, USA: The Pennsylvania State University, Eberly College of Science; 2006.
Google Scholar
Alhamdan NA, Almazrou YY, Alswaidi FM, Choudhry AJ: Premarital screening for thalassemia and sickle cell disease in Saudi Arabia. Genet Med. 2007, 9: 372-377. 10.1097/GIM.0b013e318065a9e8.
Google Scholar
Kuliev A, Rechitsky S, Verlinsky O, Ivakhnenko V, Evsikov S, Wolf G, Angastiniotis M, Georghiou D, Kukharenko V, Strom C, Verlinsky Y: Preimplantation diagnosis of thalassemias. J Assist Reprod Genet. 1998, 15: 219-225. 10.1023/A:1022571822585.
CAS
PubMed Central
Google Scholar