Clinical characteristics predicting internal neurofibromas in 357 children with neurofibromatosis-1: results from a cross-selectional study

Table 3 Characteristics independently associated with internal neurofibromas in the multivariate analysis on complete cases (n = 184) and after multiple imputation (n = 357)

	Complete-case analysis^a, n = 184			Imputed data^b, n = 357
	Odds ratios	95% CI†	P value‡	Odds ratios	95% CI*	P value**
Age	1.12 ^x	1.02-1.23	0.012	1.16 ^x	1.07-1.27	0.001
Subcutaneous/plexiform NFs
- None	1			1
- Either subcutaneous or plexiform NFs	1.15	0.42-3.15	0.781	1.06	0.40-2.80	0.901
- Both subcutaneous and plexiform NFs	4.95	1.80-13.64	0.002	5.89	2.18-15.89	<10^-4
Xanthogranuloma	4.51	0.94-21.73	0.06	6.80	1.52-30.44	0.012

^aExcluding individuals with missing values.
^bMissing data imputed using imputation with chain equations.
† Odds ratio with 95% confidence interval (95% CI) by logistic regression.
‡ P value by logistic regression.
^xOR with 95% CI giving the risk increase for a 1-year increase in age.
*Odds ratio with 95% confidence interval (95% CI) by logistic regression with multiple imputation.
** P value by logistic regression with multiple imputation.
NF neurofibroma.

ISSN: 1750-1172