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Table 6 Atypical hemolytic uremic syndrome in children: age at onset and plasma C3 concentration as indicators of complement anomaly to screen in priority

From: Atypical hemolytic uremic syndrome

Age at onset Complement abnormality to screen first
Birth to < 12 months ± decreased C3 CFH , CFI, C3 mutation
> 1 year + normal C3 MCP decreased expression/mutation
> 1 year + decreased C3 CFH, CFI, C3 mutation
7-11 years ± decreased C3 Anti-CFH antibodies
  1. CFH: factor H; CFI: factor I; MCP: membrane cofactor protein