Table 6 Atypical hemolytic uremic syndrome in children: age at onset and plasma C3 concentration as indicators of complement anomaly to screen in priority
Age at onset | Complement abnormality to screen first |
|---|---|
Birth to < 12 months ± decreased C3 | CFH , CFI, C3 mutation |
> 1 year + normal C3 | MCP decreased expression/mutation |
> 1 year + decreased C3 | CFH, CFI, C3 mutation |
7-11 years ± decreased C3 | Anti-CFH antibodies |