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Table 5 Genetic screening of the complement system

From: Atypical hemolytic uremic syndrome

Gene Location Method of choice for mutation screening Number of exons
CFH RCA, Chr 1q32 Direct sequencing analysis 22
CFI Chr 4q25 Direct sequencing analysis 13
MCP RCA, Chr 1q32 Direct sequencing analysis 14
C3 Chr 19p13.3 Direct sequencing analysis 42
CFB Chr 6p21.3 Direct sequencing analysis 18
THBD Chr 20p11.2 Direct sequencing analysis 1
  1. Chr, chromosome; CFH, factor H; CFHR1, factor H-related protein 1; CFI, factor I; MCP, membrane cofactor protein; CFB, factor B; THBD, thrombomodulin.