Table 2 Differential diagnosis of cerebellar ataxia other than ADCA
Drug Effect | Phenytoin, 5-fluorouracil, cytosine arabinoside, bismuth (Pepto-Bismol®), mercury-containing fungicides, and lithium |
|---|---|
Toxin | Ethanol, methyl mercurial compounds, solvents containing toluene and metals such as lead, manganese, and tin |
Nutritional | Vitamin E deficiency, thiamine deficiency (Wernike-Korsakoff syndrome), Gluten sensitivity (Celiac sprue) |
Endocrinopathy | Hypothyroidism and hypopituitarism |
Infection | HIV, varicella, Epstein-Barr, prion (Creutzfeldt-Jakob, Kuru etc.) |
Postinfection | Guillain-Barre and Bickerstaff's encephalitis |
Structural or lesional | Ischemic infarction, hemorrhage, neoplasm, demyelination, abscess etc. |
Neurodegeneration | Multiple systems atrophy and recessively inherited cerebellar ataxias |
Paraneoplastic | Small cell, breast, and ovarian cancer |
Other | Idiopathic late onset cerebellar ataxia and ataxia with antiglutamate decarboxylase antibodies |