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Table 2 Differential diagnosis of cerebellar ataxia other than ADCA

From: Autosomal dominant cerebellar ataxia type I: A review of the phenotypic and genotypic characteristics

Drug Effect Phenytoin, 5-fluorouracil, cytosine arabinoside, bismuth (Pepto-Bismol®), mercury-containing fungicides, and lithium
Toxin Ethanol, methyl mercurial compounds, solvents containing toluene and metals such as lead, manganese, and tin
Nutritional Vitamin E deficiency, thiamine deficiency (Wernike-Korsakoff syndrome), Gluten sensitivity (Celiac sprue)
Endocrinopathy Hypothyroidism and hypopituitarism
Infection HIV, varicella, Epstein-Barr, prion (Creutzfeldt-Jakob, Kuru etc.)
Postinfection Guillain-Barre and Bickerstaff's encephalitis
Structural or lesional Ischemic infarction, hemorrhage, neoplasm, demyelination, abscess etc.
Neurodegeneration Multiple systems atrophy and recessively inherited cerebellar ataxias
Paraneoplastic Small cell, breast, and ovarian cancer
Other Idiopathic late onset cerebellar ataxia and ataxia with antiglutamate decarboxylase antibodies
  1. ADCA = autosomal dominant cerebellar ataxia; HIV = human immunodeficiency virus