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Table 1 Clinical signs in ADCA type 1

From: Autosomal dominant cerebellar ataxia type I: A review of the phenotypic and genotypic characteristics

Clinical Signs (other than ataxia)

ADCA type 1

Slow Saccades

SCA1, SCA2, SCA3, and SCA7

Ophthalmoplegia

SCA1, SCA2 and SCA3

UMN signs

SCA1, SCA3, and SCA12 (sometimes SCA8)

Extrapyramidal

SCA3, and SCA12 (Parkinsonism)

SCA3 (Dystonia)

SCA2, and occasionally SCA1, SCA3, and SCA19(Myoclonus)

SCA12, SCA16, SCA19

Cortical

SCA13, SCA21

SCA17 (Dementia, psychosis, and epilepsy)

Pontine Signs

SCA1, SCA2, and SCA3

Fasciculations

SCA3

Peripheral Neuropathy

SCA3, SCA4, SCA18

  1. ADCA = autosomal dominant cerebellar ataxia; SCA = spinocerebellar ataxia; UMN = upper motor neuron