Skip to main content

Hypothalamic involvement in premature aging laminopathies

Caloric restriction (CR), the reduced intake of calories without malnutrition, extends lifespan of many organisms, from yeast to mammals, and delays the progression of age-related diseases. Evidence show that hypothalamus is a crucial brain region for the progress of whole-body aging[1] and the beneficial effects induced by CR are regulated by nutrient-sensing neurons located in the hypothalamus[2]. Although CR's beneficial effects in delaying human aging are promising, its application for long periods is very difficult to maintain and not feasible to apply to fragile children with progeria. To overcome this problem, the induction of protective endogenous mechanisms, or pharmacological agents, could theoretically be used to mimic the beneficial effects of CR without its discomfort. Our group showed that hypothalamus of Zmpste24-/- mouse has lower levels of Neuropeptide Y, comparing to wild-type animals. Moreover, they showed that targeting the Neuropeptide Y system in hypothalamus, as a CR mimetic strategy, delays or reverts some ageing features of Zmpste24-/- mice. Further studies are needed to confirm this innovative approach and if it could be translational to progeria children.

References

  1. 1.

    Zhang G, Li J, Purkayastha S, Tang Y, Zhang H, Yin Y, et al: Hypothalamic programming of systemic ageing involving IKK-beta, NF-kappaB and GnRH. Nature. 2013, 497 (7448): 211-6.

    PubMed  CAS  PubMed Central  Article  Google Scholar 

  2. 2.

    Dacks PA, Moreno CL, Kim ES, Marcellino BK, Mobbs CV: Role of the hypothalamus in mediating protective effects of dietary restriction during aging. Frontiers in neuroendocrinology. 2013, 34 (2): 95-106.

    PubMed  CAS  PubMed Central  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Claudia Cavadas.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Cavadas, C. Hypothalamic involvement in premature aging laminopathies. Orphanet J Rare Dis 10, O6 (2015). https://doi.org/10.1186/1750-1172-10-S2-O6

Download citation

Keywords

  • Public Health
  • Beneficial Effect
  • Brain Region
  • Caloric Restriction
  • Pharmacological Agent