Fig. 4
From: Genetic analysis of 37 cases with primary periodic paralysis in Chinese patients
CACNA1S and SCN4A mutations included in our study are pictured in the same structural model channel. Both Cav1.1 and Nav1.4 channels are composed of four homologous transmembrane domains (DI–DIV); each containing six transmembrane domains (S1-S6). Plus (+) symbolizes the positive charges in segment 4 of the calcium/sodium channels. Black square: mutations in the Nav1.4 channel; Blue hexagon: mutations in the Cav1.1 channel. The figure is adapted from Brugnoni et al. (2022)