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Fig. 4 | Orphanet Journal of Rare Diseases

Fig. 4

From: Identification and characterization of a new pathologic mutation in a large Leber hereditary optic neuropathy pedigree

Fig. 4

Phenotypic results from the study of negative control (Oc, white), positive control (O3460, red), and mutant (O3734, green) cybrids. a Levels of different protein subunits from oxidative phosphorylation (OXPHOS) complexes (in brackets) (N = 3). Picture of a Western blot immunodetection and quantitative graphic. M, molecular weight marker. b Citrate synthase specific activities (N = 3). c Oxygen consumption in cybrids exposed to growing concentrations of capsaicin. Means and standard deviations are shown (N = 4). Hashtags (#) and asterisks (*) indicate statistically significant differences (p < 0.050) versus the same cybrid without capsaicin and the negative control cybrid (Oc) at the same capsaicin concentration, respectively

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