Table 2 Distribution-based MCID for 6MWD (% predicted)

Overall

122

8.11

6.48

5.40

3.40

2.72

2.27

Baseline 6MWD subgroups

 Baseline 6MWD < 150 m

8

3.37

2.70

2.25

2.16

1.73

1.44

 Baseline 6MWD < 300 m

33

6.16

4.93

4.11

3.23

2.58

2.15

 Baseline 6MWD < 400 m

84

7.41

5.93

4.94

3.79

3.03

2.53

 Baseline 6MWD < 450 m

95

7.59

6.07

5.06

3.61

2.89

2.41

 Baseline 6MWD ≥ 450 m

27

3.73

2.98

2.49

2.50

2.00

1.67

BMI subgroups

 Underweight

7

6.49

5.19

4.33

3.47

2.78

2.32

 Normal weight

63

7.99

6.39

5.33

3.63

2.91

2.42

 Normal weight

30

7.75

6.20

5.17

3.24

2.59

2.16

 Obese

22

9.57

7.65

6.38

2.91

2.33

1.94

Comorbidities subgroups

 Having had knee or hip surgery in the past

8

7.32

5.85

4.88

3.2

2.56

2.13

 COPD

3

8.63

6.9

5.75

1.85

1.48

1.23

 Heart failure

1

NA

NA

NA

NA

NA

NA