Table 1 Anchor-based MCID for 6MWD (% predicted)
From: Minimal clinically important differences in six-minute walking distance in late-onset Pompe disease
Subgroup | PROMIS PF as Anchor MCID≥0 | SGIC as Anchor MCID≥4 | FVC as Anchor MCID≥3% | |
|---|---|---|---|---|
Overall | N | 71 | 94 | 22 |
MCID (SD), % | 4.93 (7.05) | 4.45 (6.84) | 4.85 (6.99) | |
Baseline 6MWD subgroups | ||||
Baseline 6MWD < 150 m | N | 4 | 4 | 3 |
MCID (SD), % | -0.74 (4.89) | 1.49 (2.40) | -0.63 (2.07) | |
Baseline 6MWD < 300 m | N | 20 | 24 | 9 |
MCID (SD), % | 4.16 (6.79) | 4.04 (6.34) | 3.59 (6.16) | |
Baseline 6MWD < 400 m | N | 46 | 65 | 18 |
MCID (SD), % | 5.00 (8.28) | 4.78 (7.69) | 4.99 (7.33) | |
Baseline 6MWD < 450 m | N | 52 | 74 | 19 |
MCID (SD), % | 4.80 (7.89) | 4.54 (7.33) | 4.65 (7.27) | |
Baseline 6MWD ≥ 450 m | N | 19 | 20 | 3 |
MCID (SD), % | 5.28 (4.10) | 4.11 (4.77) | 6.12 (5.82) | |
BMI subgroups | ||||
Underweight | N | 5 | 6 | 1 |
MCID (SD), % | 4.00 (7.56) | 3.33 (6.95) | 0.50 (NA) | |
Normal weight | N | 36 | 45 | 11 |
MCID (SD), % | 7.20 (7.02) | 5.87 (7.14) | 5.95 (5.70) | |
Overweight | N | 17 | 25 | 6 |
MCID (SD), % | 1.94 (5.95) | 3.01 (6.66) | 6.34 (10.23) | |
Obese | N | 13 | 18 | 4 |
MCID (SD), % | 2.92 (6.87) | 3.24 (6.09) | 0.66 (4.51) | |
Comorbidities subgroups | ||||
Having had knee or hip surgery in the past | N | 8 | 8 | 1 |
MCID (SD), % | 9.13 (6.40) | 9.13 (6.40) | 7.25 (NA) | |
COPD | N | 3 | 2 | 1 |
MCID (SD), % | 0.37 (3.70) | -0.83 (4.35) | 2.25 (NA) | |
Heart failure | N | 1 | 1 | 0 |
MCID (SD), % | -3.90 (NA) | -3.90 (NA) | - | |