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Table 3 Logistic analysis of rapidly progressive interstitial lung disease influenced by characteristics of dermatomyositis patients

From: Elevated serum B-cell activator factor levels predict rapid progressive interstitial lung disease in anti-melanoma differentiation associated protein 5 antibody positive dermatomyositis

RP-ILD

Unadjusted

Adjusted

OR (95% CI)

p-value

OR (95% CI)

p-value

Gender, Female

1.077 (0.276–4.197)

0.915

  

Age

1.034 (0.988–1.078)

0.198

  

Myasthenia

2.291 (0.595–8.825)

0.228

  

Gottron’s sign

0.462 (0.125–1.703)

0.246

  

Heliotrope rash

1.350 (0.379–4.811)

0.643

  

V sign

0.690 (0.213–2.237)

0.536

  

shawl signs

0.675 (0.174–2.614)

0.570

  

Periungual erythema

1.333 (0.341–5.208)

0.679

  

arthritis

0.674 (0.174–2.614)

0.570

  

mechanic hands

1.185 (0.382–3.675)

0.769

  

skin ulcers

0.467(0.083–2.627)

0.387

  

CK, > 200 U/L

0.593 (0.088–4.009)

0.592

  

LDH, > 227 IU/L

2.235 (0.186–26.908)

0.526

  

ESR, > 21 mm/h

1.133(0.198–6.486)

0.888

  

CRP, > 8 mg/L

3.750 (0.917–15.342)

0.066

2.337 (0.487–11.228)

0.289

SF, > 336.2 ng/ml

1.373 (0.462–4.073)

0.568

  

BAFF, > 2971.5 pg/ml

11.250 (1.991–63.560)

0.006

9.389 (1.609–54.769)

0.013

  1. Binary logistical regression analysis was used in regression equation. CRP > 8 mg/L and BAFF > 2971.5 pg/mL were put into the multivariate regression analysis
  2. Anti-MDA5+DM anti-melanoma differentiation-associated protein 5 antibody positive dermatomyositis, RP-ILD rapidly progressive interstitial lung disease, CK cytokeratin, LDH lactate dehydrogenase, ESR erythrocyte sedimentation rate, CRP C-reactive protein, SF serum ferritin, BAFF B-cell activating factor
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172