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Table 2 Clinical manifestations and laboratory features

From: Elevated serum B-cell activator factor levels predict rapid progressive interstitial lung disease in anti-melanoma differentiation associated protein 5 antibody positive dermatomyositis

Parameters

non-RP-ILD

RP-ILD

p-value

Case number

19

20

 

Gender, female, no. (%)

13 (68.42%)

14 (70%)

0.915

Age, mean ± SD, years

51.05 ± 16.05

56.70 ± 10.10

0.194

Medical history, months

3.73 ± 2.90

2.35 ± 2.07

0.103

Medication

 - glucocorticoids, no. (%)

9 (47.37%)

9 (45%)

0.882

 - immunosuppressants, no. (%)

7 (36.84%)

6 (30%)

0.651

Myasthenia, no. (%)

5 (26.31%)

9 (45%)

0.224

Gottron’s sign, no. (%)

13 (68.42%)

10 (50%)

0.242

Heliotrope rash, no. (%)

5 (26.31%)

6 (30%)

0.798

V sign, no. (%)

9 (47.36%)

6 (30%)

0.265

Shawl sign, no. (%)

6 (31.57%)

4 (20%)

0.408

Periungual erythema, no. (%)

5 (26.31%)

5 (25%)

0.925

Skin ulcers, no. (%)

5 (26.31%)

2 (10%)

0.184

Mechanic’s hands, no. (%)

6 (27.27%)

7 (35%)

0.821

Arthritis, no. (%)

6 (21.21%)

4 (20%)

0.408

CK, median (range), IU/L

47.00 (35.00–122.00)

51.00 (25.50–98.25)

0.561

LDH, median (range), U/L

317.00 (253.00–418.00)

319.00 (277.25–423.00)

0.853

ESR, median (range), mm/H

33.50 (22.00–46.50)

41.00 (21.00–54.00)

0.348

SF, median (range), ng/mL

586.10 (453.25–876.70)

916.40 (641.75–1121.93)

0.692

CRP, median (range), mg/L

3.96 (2.17–7.99)

8.81 (2.93–31.88)

0.021

BAFF, mean ± SD, pg/mL

3297.28 ± 1794.69

4549.78 ± 1839.97

0.040

  1. Data are presented as mean ± SD or median (range) or case number (percentage). Student’s t-test, Pearson’s Chi square test and analysis of variance (ANOVA) were used to analysis. All of the clinical and laboratory parameters were obtained at the first evaluation
  2. Anti-MDA5+DM anti-melanoma differentiation-associated protein 5 antibody positive dermatomyositis, RP-ILD rapidly progressive interstitial lung disease, CK cytokeratin, LDH dehydrogenase, ESR erythrocyte sedimentation rate, SF serum ferritin, CRP C-reactive protein, BAFF B-cell activating factor