Table 1 Clinical manifestations and laboratory features
Parameters | NC | ASS | MDA5+ | p-value |
|---|---|---|---|---|
Case number | 20 | 20 | 39 |  |
Gender, female, no. (%) | 11(55%) | 14(70%) | 27(69.23%) | 0.704 |
Age, mean ± SD, years | 48.95 ± 11.71 | 54.70 ± 11.87 | 53.94 ± 13.46 | 0.834 |
Medical history, months |  | 10.90 ± 16.35 | 3.00 ± 2.75 | 0.051 |
Medication | ||||
 - glucocorticoids, no. (%) |  | 8 (40%) | 18 (46.15%) | 0.652 |
 - immunosuppressants, no. (%) |  | 7(35%) | 13 (33.33%) | 0.898 |
Interstitial lung disease, no. (%) | Â | Â | Â | 0.120 |
 non-ILD |  | 2 (10%) | 7 (17.95%) |  |
 ILD |  | 12 (60%) | 12 (30.77%) |  |
 RP-ILD |  | 6 (30%) | 20 (51.28%) |  |
Myasthenia, no. (%) |  | 1 (5%) | 14 (35.89%) | 0.010 |
Gottron’s sign, no. (%) |  | 4 (20%) | 23 (58.90%) | 0.004 |
Heliotrope rash, no. (%) |  | 1 (5%) | 11 (28.20%) | 0.044 |
V sign, no. (%) |  | 1 (5%) | 15 (38.46%) | 0.006 |
Shawl sign, no. (%) |  | 1 (5%) | 10 (25.64%) | 0.079 |
Periungual erythema, no. (%) |  | 0 (0%) | 10 (25.64%) | 0.012 |
Skin ulcers, no. (%) |  | 0 (0%) | 7 (17.95%) | 0.083 |
Mechanic’s hands, no. (%) |  | 4 (20%) | 13 (33.33%) | 0.284 |
Arthritis, no. (%) |  | 1 (5%) | 10 (25.64%) | 0.079 |
CK, median (range), IU/L |  | 64.00 (39.75–92.50) | 47.00 (29.00–105.00) | 0.659 |
LDH, median (range), U/L |  | 268.50 (210.25–367.00) | 319.00 (276.00–418.00) | 0.070 |
ESR, median (range), mm/H |  | 36.00 (7.00–45.00) | 36.00 (25.00–48.75) | 0.761 |
SF, mean ± SD, ng/mL |  | 258.20 ± 156.77 | 916.94 ± 771.48 | 0.001 |
CRP, median (range), mg/L |  | 6.30 (1.62–27.82) | 4.94 (2.30–11.40) | 0.692 |
BAFF, mean ± SD, pg/mL | 2486.28 ± 767.97 | 2540.89 ± 1403.04 | 3882.32 ± 1880.09 | 0.001 |