Table 4 Clinical score of symptoms

Inflammatory symptoms

 Rash (area of rash)

 > 25%

2

5 -25%

1

 < 5%

0

 Ear canal lesions

Pus, itching, oozing

2

Hearing abnormalities

1

None

0

 Bone damage

Pain, abnormal posture

1

None

0

 Gastrointestinal symptoms

Diarrhea

1

None

0

 Pulmonary symptoms

Need oxygen

2

Symptomatic, no need for oxygen

1

None

0

 Liver symptoms (Child–Pugh classification)

Grade C

3

Grade B

2

Grade A

0

 Endocrine system (excluding diabetes insipidus)

Replacement therapy

2

No replacement therapy required

0

 Central nervous system symptoms

Central nervous system mass or diabetes insipidus

3

Decreased urine output

1

Asymptomatic

0

Malignant symptoms

 Non-infectious fever

 ≥ 38 ℃

3

None

0

 Gingival or palatal swelling

Loose teeth, swollen gums

1

None

0

 Splenomegaly

Flat umbilicus under spleen ribs

3

Spleen subcostal > 2 cm

2

Spleen subcostal < 2 cm

1

Spleen under rib

0

 Mass of body or organ

Mediastinal mass

3

No placeholder

0

 Lymphadenopathy

Lymph nodes > 2 cm

2

Lymph nodes < 2 cm

0

 Hematologic symptoms

Hemoglobin < 110 g/L

or platelet < 140 × 10 ⁹ /L

3

normal

0