Table 1 Demographics of the study population
Overall (N = 64,057) | Male (N = 21,823) | Female (N = 42,234) | |||||||
|---|---|---|---|---|---|---|---|---|---|
Normal (N = 55,942) | Osteoporosis (N = 8115) | P value | Normal (N = 18,444) | Osteoporosis (N = 3379) | P value | Normal (N = 37,498) | Osteoporosis (N = 4736) | P value | |
Age (year) | 47.30 (10.53) | 56.93 (9.13) | < 0.001* | 48.07 (11.42) | 54.46 (10.16) | < 0.001* | 46.93 (10.04) | 58.68 (7.86) | < 0.001* |
Gender | < 0.001* | - | - | ||||||
Male | 18,444 (33.0%) | 3379 (41.6%) | 18,444 (100.0%) | 3379 (100.0%) | 0 (0.0%) | 0 (0.0%) | |||
Female | 37,498 (67.0%) | 4736 (58.4%) | 0 (0.0%) | 0 (0.0%) | 37,498 (100.0%) | 4736 (100.0%) | |||
BMI (kg/m2) | 24.38 (3.85) | 23.65 (3.69) | < 0.001* | 25.60 (3.54) | 24.62 (3.64) | < 0.001* | 23.78 (3.86) | 22.95 (3.56) | < 0.001* |
Smoking | 14,387 (25.7%) | 2464 (30.4%) | < 0.001* | 10,186 (55.2%) | 2153 (63.7%) | < 0.001* | 4201 (11.2%) | 311 (6.6%) | < 0.001* |
Alcohol | 2983 (5.3%) | 533 (6.6%) | < 0.001* | 2259 (12.3%) | 462 (13.7%) | 0.001* | 724 (1.9%) | 71 (1.5%) | 0.100 |
Sport Habit | 21,699 (38.8%) | 3788 (46.7%) | < 0.001* | 7986 (43.3%) | 1444 (42.7%) | 0.535 | 13,713 (36.6%) | 2344 (49.5%) | < 0.001* |
Menopause | 13,341 (35.6%) | 4172 (88.1%) | < 0.001* | – | – | – | 13,341 (35.6%) | 4172 (88.1%) | < 0.001* |
eGFRf (mL/min/1.73m2) | 104.41 (14.6) | 97.05 (15.01) | < 0.001* | 97.83 (15.22) | 94.68 (16.58) | < 0.001* | 107.64 (13.12) | 98.74 (13.53) | < 0.001* |
rs11264345 | 0.001* | 0.002* | 0.143 | ||||||
TT | 5027 (9.1%) | 635 (7.9%) | 1681 (9.2%) | 247 (7.4%) | 3346 (9.0%) | 388 (8.3%) | |||
TA | 22,979 (41.5%) | 3302 (41.1%) | 7561 (41.5%) | 1371 (41.2%) | 15,418 (41.5%) | 1931 (41.1%) | |||
AA | 27,411 (49.5%) | 4097 (51.0%) | 8987 (49.3%) | 1713 (51.4%) | 18,424 (49.5%) | 2384 (50.7%) | |||