Fig. 2

Cohen’s kappa coefficient showing the correlation between patient and physician questionnaires concerning the estimation of different disease manifestations. A Plot of Cohen’s kappa coefficient with (light blue) and without (dark blue) response option ‘unknown’, based on all patients and physicians’ questionnaires. B Plot of Cohen’s kappa coefficient based on ‘yes’ or ‘no’ responses, divided into physicians with TSC centre association (green) and without TSC centre association (red)