Table 1 The distribution of DM1 clinical features based on CTG repeats ranges
Feature | Total patients (n = 64) | CTG repeats 100–300 (n = 18) | CTG repeats 300–600 (n = 27) | CTG repeats 600–1900 (n = 19) | p |
|---|---|---|---|---|---|
Age (mean (SD)) | 41 (12) | 44 (15) | 39 (11) | 43 (9) | 0.31 |
Male (%) | 36 (56.2) | 11 (61.1) | 19 (70.4) | 6 (31.6) | 0.02 |
CTG repeat (mean (SD)) | 468 (139) | 174 (44) | 447 (81) | 754 (105) | 0.33 |
Onset age (%) | 29 (13) | 38 (11) | 25 (12) | 31 (13) | 0.24 |
Muscle weakness | 59 (92.2) | 15 (83.3) | 25 (92.6) | 19 (100) | 0.42 |
Myotonia (%) | 55 (85.9) | 16 (88.9) | 25 (92.6) | 14 (73.7) | 0.18 |
Fatigue (%) | 47 (73.4) | 11 (61.1) | 21 (77.8) | 15 (78.9) | 0.38 |
Heart palpitation (%) | 20 (31.3) | 8 (44.4) | 9 (33.3) | 3 (15.8) | 0.16 |
Cataract surgery (%) | 9 (14.1) | 3 (16.7) | 4 (14.8) | 2 (10.5) | 0.86 |
Tumor (%) | 3 (4.7) | 1 (5.6) | 0 (0.0) | 2 (10.5) | 0.25 |
Diabetes (%) | 11 (17.2) | 5 (27.8) | 5 (18.5) | 1 (5.3) | 0.19 |
Dyspnea (%) | 15 (23.4) | 4 (22.2) | 6 (22.2) | 5 (26.3) | 0.94 |
Insomnia (%) | 18 (28.1) | 7 (38.9) | 7 (25.9) | 4 (21.1) | 0.46 |
Daytime sleepiness (%) | 45 (70.3) | 13 (72.2) | 23 (85.2) | 9 (47.4) | 0.02 |
FSS score (mean (SD)) | 42.02 (15.01) | 42.44 (14.96) | 43.04 (14.29) | 44.42 (16.44) | 0.62 |
ESS score (mean (SD)) | 10.50 (6.18) | 11.50 (7.67) | 10.85 (5.62) | 9.05 (5.40) | 0.46 |