Echocardiographic abnormalities and joint hypermobility in Chinese patients with Osteogenesis imperfecta

Mei, Yazhao; Jiang, Yunyi; Shen, Li; Meng, Zheying; Zhang, Zhenlin; Zhang, Hao

doi:10.1186/s13023-024-03089-x

Orphanet Journal of Rare Diseases

Table 3 Simple regression analysis of echocardiographic parameters

From: Echocardiographic abnormalities and joint hypermobility in Chinese patients with Osteogenesis imperfecta

	Dependent variable
Independent variable	AD		LAD		IVST		LVPWT		LVEDd		LVESd		LVEF		FS		LVM
Independent variable	β	P	β	P	β	P	β	P	β	P	β	P	β	P	β	P	β	P
A. In the juvenile group
Age	0.669	<0.001	0.838	<0.001	0.225	<0.001	0.231	<0.001	1.128	<0.001	0.714	<0.001	-0.081	0.316	0.012	0.932	6.905	<0.001
Sex	-2.283	<0.001	-2.067	0.047	-0.448	0.074	-0.462	0.055	-4.765	<0.001	-3.144	<0.001	0.526	0.393	1.719	0.121	-25.242	<0.001
BSA	6.616	<0.001	10.006	<0.001	2.241	<0.001	2.150	<0.001	12.425	<0.001	8.030	<0.001	-0.938	0.220	-1.246	0.370	73.623	<0.001
SBP	0.164	<0.001	0.203	<0.001	0.051	<0.001	0.039	<0.001	0.237	<0.001	0.129	<0.001	0.026	0.322	0.071	0.134	1.396	<0.001
DBP	0.161	<0.001	0.209	<0.001	0.045	0.001	0.041	0.001	0.220	<0.001	0.118	0.006	0.036	0.274	0.083	0.168	1.351	<0.001
OI	0.497	0.512	-0.682	0.574	0.523	0.072	0.605	0.034	1.178	0.396	0.590	0.535	-0.091	0.900	2.049	0.119	8.252	0.328
B. In the adult group
Age	0.062	<0.001	0.110	0.008	0.009	0.480	0.007	0.510	0.003	0.940	-0.035	0.213	0.076	0.047	0.069	0.027	0.302	0.602
Sex	-1.261	0.025	-0.327	0.729	-0.540	0.060	-0.426	0.083	-2.436	0.003	-1.649	0.009	0.452	0.601	0.356	0.614	-45.668	<0.001
BSA	5.201	<0.001	7.107	<0.001	1.510	0.013	1.412	0.008	7.217	<0.001	4.406	0.001	-0.128	0.946	-0.051	0.973	169.534	<0.001
SBP	0.034	0.185	0.002	0.960	0.005	0.697	0.007	0.516	0.015	0.705	-0.012	0.678	0.047	0.229	0.039	0.223	0.444	0.435
DBP	0.031	0.385	0.053	0.382	0.009	0.635	0.017	0.269	0.065	0.231	0.024	0.554	0.003	0.952	0.004	0.930	0.689	0.386
OI	1.245	0.038	-0.523	0.603	0.110	0.723	0.131	0.627	1.136	0.208	0.577	0.398	0.531	0.571	0.195	0.796	86.304	<0.001

Abbreviations OI: osteogenesis imperfecta; BSA: body surface area; SBP: systolic blood pressure; DBP: diastolic blood pressure; AD: aorta diameter; LAD: left atrium diameter; IVST: interventricular septum thickness; LVPWT: left ventricular posterior wall thickness; LVEDd: left ventricular end-diastolic diameter; LVESd: left ventricular end-systolic diameter; LVEF: left ventricular ejection fraction; FS: fractional shortening; LVM: Left ventricular mass. Bold P values indicate significance.

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ISSN: 1750-1172

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