Table 1 Baseline characteristics of osteogenesis imperfecta patients and controls
| Â | OI-Juveniles | Control-Juveniles | P | OI-Adults | Control-Adults | P |
|---|---|---|---|---|---|---|
Number of patients | 25 | 79 | / | 23 | 50 | / |
Age (± SD), year | 11.0 ± 4.4 | 12.6 ± 3.5 | 0.051 | 39.54 ± 12.18 | 41.00 ± 10.75 | 0.608 |
Sex, male/female | 18/7 | 42/37 | 0.097 | 6/17 | 25/25 | 0.055 |
Height (± SD), cm | 138.2 ± 26.2 | 156.7 ± 18.5 | 0.003 | 153.3 ± 9.9 | 166.7 ± 8.0 | <0.001 |
Weight (± SD), kg | 43.2 ± 24.3 | 51.9 ± 18.9 | 0.064 | 52.0 ± 10.2 | 65.7 ± 14.0 | <0.001 |
BSA (± SD), m2 | 1.3 ± 0.5 | 1.5 ± 0.4 | 0.013 | 1.5 ± 0.2 | 1.7 ± 0.2 | <0.001 |
SBP, mmHg | 109.2 ± 18.3 | 113.2 ± 9.8 | 0.348 | 115.8 ± 12.2 | 118.6 ± 10.9 | 0.352 |
DBP, mmHg | 70.1 ± 8.1 | 71.3 ± 8.1 | 0.700 | 75.8 ± 8.1 | 76.2 ± 8.1 | 0.855 |
Lumbar spine BMD(± SD), g/cm2 | 0.53 ± 0.19 | / | / | 0.81 ± 0.14 | / | / |
Lumbar spine BMD Z score (± SD) | -1.80 ± 1.87 | / | / | -2.20 ± 1.07 | / | / |
Femoral neck BMD(± SD), g/cm2 | 0.52 ± 0.19 | / | / | 0.71 ± 0.13 | / | / |
Femoral neck BMD Z score (± SD) | -3.0 ± 1.48 | / | / | -1.34 ± 0.96 | / | / |
Blue sclera, n (%) | 16 (64%) | / | / | 20 (87%) | / | / |
Dentinogenesis imperfecta, n (%) | 8 (32%) | / | / | 8 (35%) | / | / |
Hearing loss, n (%) | 1 (4%) | / | / | 11 (48%) | / | / |
Scoliosis, n (%) | 2 (8%) | / | / | 3 (13%) | / | / |
Cardiac diseases related symptoms/treatment, n (%) | 0 | / | / | 2 (9%) | / | / |
Type 1 | 15 (60%) | / | / | 20 (87%) | / | / |
Type 3 | 1 (4%) | / | / | 0 | / | / |
Type 4 Type 5 | 8 (32%) 1 (4%) | / / | / / | 2 (9%) 1 (4%) | / / | / / |