Table 3 Milestone acquisition and regression
From: The spectrum of neurological presentation in individuals affected by TBL1XR1 gene defects
Developmental milestone | Number acquired n (%) | Number regressed n (%) | Acquisition age (mo) Median (range) | Regression age (mo) Median (range) |
|---|---|---|---|---|
Social smile | 38 (93) | 3 (8) | 4 (2–48) | 12 (7–204) |
Sustained eye contact | 30 (73) | 1 (3) | 6 (3–72) | 12 (12) |
Reach for an object | 39 (95) | 0 (0) | 6 (1–60) | N/A |
Transfer from hand to hand | 35 (85) | 1 (3) | 9 (4–48) | NR |
Sit without propping | 34 (83) | 3 (9) | 10 (5–48) | 48 (7–192) |
Speak first words | 25 (61) | 10 (40)a | 14 (7–48) | 36 (12–144)a |
2–3 word sentences | 19 (46) | 24 (15–72) | ||
Walk without support | 29 (71) | 1 (3) | 18 (11–43) | NR |
Grasp (regression only) | NR | 4 (10)b | NR | 24 (12–36) |