Fig. 3From: Transcriptional profiling of peripheral blood mononuclear cells identifies inflammatory phenotypes in Ataxia TelangiectasiaA-T classic affected individuals show heterogeneous inflammatory pathway activities. (A) Kernel density estimate plot showing distribution of hallmark inflammatory response scores stratified by condition. (B) Stacked barplot showing proportion of samples with low [0,0.5), moderate [0.5, 0.8), or high [0.8, 1] inflammatory response levels, based on scores in (A). (C) Matrixplot showing expression of genes differentially expressed across inflammatory response levels in classic A-T affected individuals only (Wilcoxon rank-sum, FDR < 0.05). D,E,F) Boxplots of measured alpha-fetoprotein (D), % forced vital capacity (E), and rlog-normalized ATM mRNA expression (F) in mild A-T and classic A-T affected individuals, stratified by inflammatory response levelBack to article page