The male-to-female ratio in late-onset multiple acyl-CoA dehydrogenase deficiency: a systematic review and meta-analysis

Table 3 Univariable meta-regressions model for investigating influence on the male frequency of late-onset MADD

Variants	Number of tudies	Unadjusted association with male frequency of late-onset MADD				Adjusted association with male frequency of late-onset MADD
Variants	Number of tudies	Coef	Standard Error	P value	95% CI	Coef	Standard Error	P value	95% CI
Ethnic group*	34	0.350	0.100	< 0.001	0.154–0.547	0.316	0.158	0.045	0.007–0.625
Risk of bias	34	0.940	0.495	0.058	-0.030-1.910	-	-	-	-
Onset age	33	0.010	0.005	0.026	0.001–0.019	0.005	0.006	0.392	-0.006-0.016
MFR of general population of country	34	-0.077	0.242	0.750	-0.551-0.397	-	-	-	-
HDI of country	34	0.289	0.098	0.003	0.097–0.481	-0.003	0.173	0.987	-0.342-0.337

Legend: MADD, multiple acyl-CoA dehydrogenase deficiency; MFR, male to female ratio; Coef, coefficient; CI, confidence interval; HDI, Human Development Index
*Ethnic group: East-Asians or non-East-Asians

ISSN: 1750-1172