Fig. 2

Rare AATD variants reported in Europe. For countries with more than 10 rare variants reported (France, Germany, Italy, Netherlands, Poland, Portugal, Spain, Switzerland, and the UK) only the 10 most frequently reported rare variants are shown. The full list of all rare variants by geographical region and country are shown in Additional file 1: Tables S4, S5, S6. Countries are color-coded according to the most frequently reported variant in each country. For countries where the most frequently reported group was ‘unidentified Null/rare variants’, countries (Germany and Switzerland) are color-coded according to the next known rare variant. *Q0/rare = unidentified Null/rare variant at the time of source article publication. ^†Variants identified by IEF; all other variants were genetically identified