Table 4 Prevalence rates of pathogenic chromosomal aberrations in different soft marker groups (n = 6647)
Ultrasound category | N | Chromosomal aberrations | p value | Aneuploidies | p value | P CNVs | p value |
|---|---|---|---|---|---|---|---|
Multiple soft markers | 192 | 0 (0.00) | 1.000 | 0 (0.00) | – | 0 (0.00) | – |
EIF | 5429 | 12 (0.22) | 0.008 | 8 (0.15) | 0.012 | 4 (0.07) | 0.672 |
Mild ventriculomegaly | 7 | 0 (0.00) | 1.000 | 0 (0.00) | – | 0 (0.00) | – |
CPCs | 609 | 3 (0.50) | 0.663 | 3 (0.50) | 0.313 | 0 (0.00) | – |
Echogenic bowel | 24 | 1 (4.17) | 0.073 | 1 (4.17) | 0.053 | 0 (0.00) | – |
Mild pyelectasis | 154 | 0 (0.00) | 1.000 | 0 (0.00) | – | 0 (0.00) | – |
SUA | 141 | 1 (0.71) | 0.363 | 1 (0.71) | 0.275 | 0 (0.00) | – |
Absent or hypoplastic nasal bone | 63 | 2 (3.17) | 0.017 | 2 (3.17) | 0.009 | 0 (0.00) | – |
ARSA | 28 | 2 (7.14) | 0.003 | 0 (0.00) | – | 2 (7.14) | < 0.001 |
Total (n) | 6647 | 21 (0.32) | 15 (0.23) | 6 (0.09) |