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Table 4 Surgery Costs of Patients with VHL-CNS-Hb or VHL-pNET

From: Epidemiology and economic burden of Von Hippel-Lindau Disease-associated central nervous system hemangioblastomas and pancreatic neuroendocrine tumors in the United States

 

Unadjusted Costs for VHL-CNS-Hb Cohort

Unadjusted Costs for VHL-pNET Cohort

Healthcare Costs (2020 USD)

(N = 220)

(N = 20)

 

Mean (SD)

Median [IQR]

Mean (SD)

Median [IQR]

Nephrectomies

    

All patients (mean cost, annualized)

$408 (± $2,038)

$0 [$0, $0]

--

--

Average hospitalization cost for a nephrectomy procedure

$36,249 (± $10,568)

$35,443 [$29,338, $42,256]

--

--

Laser therapy to retina

    

All patients (mean cost, annualized)

$59 (± $441)

$0 [$0, $0]

$10 (± $43)

$0 [$0, $0]

Average outpatient cost for laser therapy to retina

$2,234 (± $2,899)

$1,154 [$738, $1,691]

$699 (± $0)

$699 [$699, $699]

Surgical removal of CNS-Hb

    

All patients (mean cost, annualized)

$9,297 (± $38,566)

$0 [$0, $0]

--

--

Average hospitalization cost for surgical removal of cerebellar and spinal Hb

$94,439 (± $70,100)

$81,786 [$54,598, $92,065]

--

--

Surgical removal of adrenal pheochromocytomas

    

All patients (mean cost, annualized)

$123 (± $1,060)

$0 [$0, $0]

$9,837 (± $25,607)

$0 [$0, $0]

Average hospitalization cost for surgical removal of adrenal pheochromocytoma

$39,291 (± $367)

$39,399 [$38,882, $39,592]

$87,880 (± $42,471)

$83,659 [$53,115, $122,646]

Surgical removal of pNET tumors

    

All patients (mean cost, annualized)

$221 (± $2,327)

$0 [$0, $0]

$16,917 (± $24,222)

$899 [$0, $33,846]

Average hospitalization cost for surgical removal of pNET tumor

$56,451 (± $23,288)

$56,451 [$39,984, $72,918]

$62,300 (± $39,900)

$59,634 [$26,113, $81,290]

  1. Abbreviations: CNS: central nervous system; Hb: hemangioblastoma; IQR: interquartile range; pNET: pancreatic neuroendocrine tumor; SD: standard deviation; USD: United States dollar; VHL: von Hippel-Lindau.