A systematic review on the birth prevalence of metachromatic leukodystrophy

Table 3 Estimated 2-year point prevalence of MLD according to race and ethnicity

Race and/or ethnicity	Unadjusted^a prevalence per 100,000 patients (95% CI)	p value
White non-Hispanic	2.2 (1.7–2.8)	Reference
Asian	2 (0.6–6.1)	0.85
Black Hispanic	0 (0–100,000)	> 0.99
Black non-Hispanic	1.6 (1.0–2.5)	0.22
Multiple	1.4 (0.7–2.7)	0.20
American Indian	13.9 (3.5–55.4)	0.01
Other	4.1 (2.6–6.6)	0.02
Pacific Islander	0 (0–100,000)	> 0.99
White Hispanic	0.9 (0.5–1.8)	0.02

CI confidence interval; MLD metachromatic leukodystrophy
Bold values denote significance
Data are from a study of children and adolescents in the US Children’s Hospital Association’s Pediatric Health Information System database from October 2015 to September 2017; of these patients, 139 received a diagnosis of MLD [36]
^aThere were no adjustments between cases with and without MLD in the database to account for potential differences in sex, insurance type, urban or rural status, household income, number of inpatient days for the patient for all admissions during the study, or patient age

ISSN: 1750-1172