Weighting | Characteristic | Patients with GD, n (%) (n = 265) | Controls, n (%) (n = 3445) | OR (95% CI) |
---|---|---|---|---|
3 points | Splenomegaly | 65 (24.5) | 18 (0.52) | 61.9 (36.0–106.3) |
2 points | Thrombocytopenia (platelet count 50–150 × 109/L) | 107 (60.5) [177 samples] | 175 (10.0) [1750 samples] | 13.7 (9.8–19.3) |
Bone issues | 95 (35.8) | 1168 (33.9) | 1.1 (0.8–1.4) | |
Anemia (Hb 9.5–14.0 g/dL) | 147 (83.0) [177 samples] | 1362 (77.8) [1750 samples] | 1.4 (0.9–2.1) | |
Hyperferritinemia (ferritin 300–1000 ng/mL) | 45 (41.7) [108 samples] | 20 (2.4) [829 samples] | 28.9 (16.1–51.9) | |
Gammopathy (IgG, IgM, IgA, and IgE)a (> normal range) | 29 (40.8) [71 samples] | 56 (16.4) [342 samples] | 3.5 (2.0–6.1) | |
Jewish ancestry | 257 (98) [262 samples] | 3140 (92.4) [3397 samples] | 4.5 (1.8–11.0) | |
1.5 points | Hepatomegalyb | 23 (8.7) | 12 (0.35) | 27.2 (13.4–55.3) |
1 point | Thrombocytopenia (platelet count < 50 × 109/L) | 11 (6.2) [177 samples] | 2 (0.11) [1750 samples] | 57.9 (12.7–263.0) |
Anemia (Hb < 9.5 g/L) | 16 (9.0) [177 samples] | 50 (2.8) [1750 samples] | 3.4 (1.9–6.0) | |
Hyperferritinemia (ferritin > 1000 ng/mL) | 4 (3.8) [104 samples] | 1 (0.1) [829 samples] | 33.1 (3.7–299.0) | |
0.5 points | Gallstones | 18 (6.8) | 75 (2.2) | 3.3 (1.9–5.6) |
Bleeding | 27 (10.2) | 308 (8.9) | 1.2 (0.8–1.7) | |
Leukopenia (WBC < normal range) | 26 (14.7) [177 samples] | 82 (4.7) [1750 samples] | 3.5 (2.2–5.6) | |
Low bone marrow density | 24 (9.0) | 93 (2.7) | 3.6 (2.2–5.7) | |
Growth retardationc | 13 (4.9) | 73 (2.1) | 1.8 (0.9–3.2) | |
Fatigued | 28 (10.6) | 398 (11.6) | 0.9 (0.6–1.4) | |
Dyslipidemia (HDL cholesterol < 35 mg/dL) | 81 (61.4) [132 samples] | 199 (15.2) [1308 samples] | 8.9 (6.0–13.0) | |
Elevated ACE (> normal range) | 12 (80.0) [15 samples] | 3 (27.3) [11 samples] | 10.7 (1.7–66.7) | |
Family history of PD | 0 | 0 | – | |
Age at diagnosis < 18 years | 50 (18.9) | 685 (19.9)e | – |