Table 1 Patients characteristics by gender. 13 years follow-up time from histological report

Histological report years, n (%)

 < 1981

2 (6%)

17 (23%)

19 (18.1%)

 1981–1990

2 (6%)

10 (14%)

12 (11.4%)

 1991–2000

7 (23%)

14 (19%)

21 (20.0%)

 2001–2009

7 (23%)

13 (18%)

20 (19.0%)

 > 2009

11 (35%)

20 (27%)

31 (29.5%)

 Not Available

2 (6%)

0 (0%)

2 (1.9%)

SPC^* age onset, year

Median (IQR)

37 (30, 50)

33.5 (25, 43)

34 (26.5, 44)

Histological grade, n (%)

 1

22 (71%)

37 (50%)

59 (56.2%)

 2

7 (23%)

33 (45%)

40 (38.1%)

 3

1 (3%)

3 (4%)

4 (3.8%)

 Not Available

1 (3%)

1 (1%)

2 (1.9%)

Axial site, n (%)

 No

12 (39%)

33 (45%)

45 (42.9%)

 Yes

19 (61%)

41 (55%)

60 (57.1%)

Cartilage cap thickness, cm

Median (IQR)

3 (2.5, 5.5)

3 (2, 5.75)

3 (2.2, 5.5)

 Diameter, cm

Median (IQR)

10.5 (8, 15)

11 (8.5, 14.3)

11 (8.5, 14.6)

Surgical treatment, n (%)

 Amputation

5 (16%)

10 (14%)

15 (14.3%)

 Complete resection

14 (45%)

30 (41%)

44 (41.9%)

 Debulking

8 (26%)

21 (28%)

29 (27.6%)

 Partial resection

1 (3%)

8 (11%)

9 (8.6%)

 Not Available

3 (10%)

5 (7%)

8 (7.6%)

Recurrence/Metastasis, n (%)

 No

27 (87%)

56 (76%)

83 (79.0%)

 Yes

4 (13%)

18 (24%)

22 (21.0%)

Death cause, n (%)

 Alive

31 (100%)

66 (89%)

97 (92.4%)

 Dead for disease

0 (0%)

3 (4%)

3 (2.9%)

 Dead for other causes

0 (0%)

5 (7%)

5 (4.8%)

Germinal variant, n (%)

 No

1 (3%)

2 (3%)

3 (2.9%)

 Yes

13 (42%)

34 (46%)

47 (44.8%)

 Not Available

17 (55%)

38 (51%)

55 (52.4%)

Gene, n (%)

 EXT1

10 (77%)

21 (62%)

31 (66%)

 EXT2

3 (23%)

13 (38%)

16 (34%)

Variant type, n (%)

 Big Rearrangement

0 (0%)

4 (12%)

4 (9%)

 Deletion

1 (8%)

1 (3%)

2 (4%)

 Duplication

1 (8%)

2 (6%)

3 (6%)

 Frameshift

4 (31%)

14 (41%)

18 (38%)

 Missense

3 (23%)

1 (3%)

4 (9%)

 Nonsense

3 (23%)

10 (29%)

13 (28%)

 Splicesite

1 (8%)

2 (6%)

3 (6%)