Impact of lipodystrophy on health-related quality of life: the QuaLip study

Table 3 Comparison of Short Form-36 (SF36) scores in patients with lipodystrophy to the population norms of the SF36 Health Survey in Turkey

Population Normal Levels (Men)				SF36 Components in Men with Lipodystrophy at Visit 1				SF36 Components in Men with Lipodystrophy at Visit 9
SF36	Mean	Std. Deviation	n	Mean	Std. Deviation	n	p (vs. Normal Population)	Mean	Std. Deviation	n	p (vs. Normal Population)
PF	87.2	17.10	609	75.77	20.80	13	0.018	77.27	25.82	11	0.102
RP	89.8	19.30	609	65.38	42.73	13	0.062	79.54	40.02	11	0.198
BP	85.1	16.40	609	60.54	28.50	13	0.006	78.78	40.20	11	0.301
GH	73.6	14.70	609	48.62	23.59	13	0.121	58.63	24.40	11	0.021
VT	65.7	11.90	609	55.77	31.81	13	0.002	76.13	28.75	11	0.889
SF	91.7	12.80	609	70.19	24.23	13	0.008	70.09	27.86	11	0.005
RE	92.8	15.10	609	56.41	39.40	13	0.009	60.00	17.06	11	< 0.001
MH	71.0	10.60	609	63.08	16.42	13	0.283	41.81	31.83	11	0.001

Population Normal Levels (Women)				SF36 Components in Women with Lipodsytrophy at Visit 1				SF36 Components in Women with Lipodsytrophy at Visit 9
SF-36	Mean	Std. Deviation	n	Mean	Std. Deviation	n	p (vs. Normal Population)	Mean	Std. Deviation	n	p (vs. Normal Population)
PF	80.6	21.70	670	62.13	26.49	54	< 0.001	57.33	30.98	45	< 0.001
RP	82.9	28.60	670	43.19	39.77	54	< 0.001	51.11	48.25	45	< 0.001
BP	81.0	20.20	670	57.65	31.42	54	< 0.001	61.62	28.70	45	< 0.001
GH	69.1	16.90	670	37.63	22.12	54	< 0.001	39.73	24.24	45	< 0.001
VT	63.4	13.70	670	48.06	22.75	54	< 0.001	45.44	25.35	45	< 0.001
SF	90.1	12.90	670	61.56	29.32	54	< 0.001	59.44	30.05	45	< 0.001
RE	89.0	22.50	670	44.00	40.66	54	< 0.001	57.03	47.47	45	< 0.001
MH	70.1	11.40	670	58.04	20.14	54	< 0.001	53.95	22.06	45	< 0.001

Each SF36 scale is directly transformed into a 0–100 scale on the assumption that each question carries equal weight. The lower the score, the more disability. The higher the score, the less disability (a score of zero is equivalent to a maximum disability, and a score of 100 is equivalent to no disability). These scale scores can be combined to produce two component summary scores: the Physical Component Summary (PCS) and the Mental Component Summary (MCS). Data presented as mean and standard deviation
PF, Physical Functioning; RP, Role Limitations due to Physical Health; BP, Pain; GH, General Health; VT, Vitality; SF, Social Functioning; RE, Role Limitations due to Emotional Problems; MH, Mental Health
Per local regulations, no data was collected on leptin replacement status during follow-up. All subjects were leptin naïve at baseline; however, it is likely that a subset of subjects with GL received leptin replacement during follow-up that may have caused elevations in leptin levels at year-2 visit (V9) [31]

ISSN: 1750-1172