Skip to main content

Table 2 Compositional characteristics of HM-placebo

From: Qualified placebo for trials of herbal medicine treatment in rare diseases? A cross-sectional analysis

Composition of placebo

N = 32 (%)

Example

With all ingredients of tested formula

7 (21.8)

The placebo used in this study will contain 5% of the same components of JHG

With some of the ingredients of the tested formula

3 (9.4)

The placebo was simple syrup and 0.71 ml grape syrup and 0.1% St John’s wort essential oil to reach a similar color and smell to the drug

Without HM ingredients

22 (68.8)

Placebo Tablets: ImmunoGuard® Clinical B. containing lactose 170 mg, calcium hydrophosphate, potato starch, microcristalline cellulose, magnesium stearate, silicagel

Drug concentrations of all HM used

N = 7a (%)

Example

5%

3 (42.9)

Placebo contained 5% of the active ingredient

10%

4 (57.1)

The placebo was 10% concentration FuzhengTongluofang(shengdi, shanzhurou, nvzhenzii, huainiuxi, tusizi, wuweizi, gejie, juluo, sigualuo, sanqi) granules

Excipients

N = 51b (%)

Example

Coloring agents

16 (31.4)

amaranth red, carbon black pigment, food color, caramel color

Flavoring agents

14 (27.5)

bitter taste agent, peppermint, grape syrup

Shaping agents

20 (39.2)

soybean powder, starch, and dextrin, maltodextrin, b-cyclodextrin, lactose powder, distilled water

Other agents

1 (2.0)

calcium hydrophosphate, microcristalline cellulose, magnesium stearate, silicagel, etc

  1. aThere were 7 trials that placebos used all tested HM
  2. bAny additives of the three classes of agents used will accumulate. For example, a placebo that used both bitterness and starch and lactose was recorded as flavoring and plasticizing agents