Fig. 1
From: ∆4-3-oxo-5β-reductase deficiency: favorable outcome in 16 patients treated with cholic acid
Evolution of 3-oxo-∆4 derivatives in urine of patients before (n = 6) and after (n = 13) cholic acid treatment. Data are presented as median ± interquartile range, with a logarithmic scale. Of note, among the 13 patients with quantification of 3-oxo-∆4 derivatives at last follow-up, six also had quantification at baseline. Statistical analysis was performed using non-parametric two-tailed Mann–Whitney test. CA = cholic acid