Fig. 3

Liver volume in multiples of normal (MN) and alanine aminotransferase (ALT) during placebo or olipudase alfa treatment periods. A Liver volume over time. Means are shown above and below the lines for the group crossing over to olipudase alfa from placebo and the olipudase alfa group, respectively. The dashed lines indicate hepatomegaly severity cutoffs [26]. B ALT levels over time. Means are shown above and below the lines for the group crossing over to olipudase alfa from placebo and the olipudase alfa group, respectively. The dashed line indicates the upper limit of normal