Explorative research on glucolipid metabolism and levels of adipokines in pseudohypoparathyroidism type 1 patients

Table 4 Glucolipid metabolic indices of PHP1 patients of different BMI subgroup

	PHP1-normal BMI (n = 31)	PHP1-overweight/obese (n = 18)	Normal control (n = 30)	p1	p2	p3
FBG (mmol/l)	4.69 ± 0.31	4.78 ± 0.46	4.90 (4.30–6.00)	0.336	0.404	0.951
Ins (μIU/ml)	4.85 (2.20–17.50)	8.12 ± 3.79	5.57 ± 2.85	0.833	0.028	0.033
TG (mmol/L)	0.92 (0.39–2.12)	1.17 ± 0.59	0.99 (0.31–2.95)	0.433	0.798	0.724
LDL-C (mmol/L)	2.51 ± 0.42	2.80 ± 0.71	2.62 ± 0.58	0.300	0.624	0.237
HOMA-IR	1.08 (0.50–4.04)	1.85 ± 0.95	1.24 ± 0.66	0.597	0.032	0.023
HOMA-IS	1.00 ± 0.48	0.64 (0.29–1.80)	0.92 (0.35–3.91)	0.592	0.032	0.023
HOMA-β (%)	98.45 (42.5–312.50)	121.33 (60–306.67)	80.48 ± 41.53	0.683	0.002	0.005
Leptin (ng/ml)	0.29 (0.11–4.79)	3.11 ± 2.00	1.16 (0.09–9.02)	0.785	0.055	0.029
Adiponectin (ng/ml)	5.96 (2.58–14.23)	4.30 (2.27–81.80)	5.39 ± 3.05	0.612	0.639	0.196
FGF21 (pg/ml)	162.84 (17.82–693.97)	133.44 (25.70–975.05)	165.29 (63.19–649.68)	0.805	0.338	0.272
TNFα (pg/ml)	12.18 ± 5.01	10.31 ± 3.78	15.47 ± 6.65	0.004	0.005	0.914
LAR	0.05 (0.02–1.49)	0.77 ± 0.67	0.19 (0.01–3.19)	0.297	0.115	0.029

PHP1: pseudohypoparathyroidism type 1; BMI: body mass index; FBG: fasting blood glucose; Ins: insulin; TG: triglyceride; LDL-C: low density lipoprotein cholesterol; HOMA-IR: homeostasis model assessment-insulin resistance; HOMA-IS: homeostasis model assessment-insulin sensitivity; HOMA-β: homeostasis model assessment-beta cell function; FGF21: fibroblast growth factor 21; TNFα: tumor necrosis factor α; LAR: leptin/adiponectin ratio; p1: p-value for comparison between PHP1-normal BMI and normal control; p2: p-value for comparison between PHP1-overweight/obese and normal control; p3: p-value for comparison between PHP1-normal BMI and PHP1- overweight/obese. p-value of less than 0.05 would be considered as of significantly difference

ISSN: 1750-1172