PHP1 (n = 49) | PHP1A (n = 14) | PHP1B (n = 35) | Normal control (n = 30) | p1 | p2 | p3 | |
---|---|---|---|---|---|---|---|
M/F (n/n) | 26/23 | 8/6 | 17/18 | 14/16 | 0.758 | 1.000 | 0.758 |
Age (years) | 25.1 ± 10.8 | 25.1 ± 8.0 | 27.4 ± 10.2 | 25.1 ± 10.8 | 0.682 | 0.524 | 1.000 |
< 18 yo [n, (%)] | 11 (22.4%) | 5 (35.7%) | 6 (17.1%) | 9 (30%) | 1.000 | 0.251 | 0.269 |
≥ 18 yo [n, (%)] | 38 (77.5%) | 9 (64.3%) | 29 (82.9%) | 21 (70%) | |||
BMI (kg/m2) | 23.88 ± 5.23 | 25.14 ± 5.72 | 23.20 ± 4.63 | 21.72 ± 3.07 | 0.050 | 0.143 | 0.332 |
Overweight [n, (%)] | 11 (22.4%) | 3 (21.4%) | 8 (22.9%) | 6 (20%) | - | - | 0.627 |
Obese [n, (%)] | 7 (14.3%) | 3 (21.4%) | 4 (11.4%) | 0 (0%) | |||
Overweight/obese [n, (%)] | 18 (36.7%) | 6 (42.8%) | 12 (34.3%) | 6 (20%) | 0.174 | 0.269 | 0.754 |
FBG (mmol/l) | 4.80 ± 0.39 | 4.61 ± 0.32 | 4.84 ± 0.38 | 4.90 (4.30–6.00) | 0.943 | 1.000 | 1.000 |
Ins (μIU/ml) | 6.00 (1.90–17.50) | 5.40 (1.90–13.80) | 6.70 (2.10–17.50) | 5.57 ± 2.85 | 1.000 | 1.000 | 1.000 |
TG (mmol/L) | 0.95 (0.33–2.63) | 1.16 ± 0.74 | 1.04 ± 0.48 | 0.99 (0.31–2.95) | 0.866 | 0.434 | 0.751 |
LDL-C (mmol/L) | 2.61 ± 0.62 | 2.25 (1.45–4.04) | 2.64 ± 0.55 | 2.62 ± 0.58 | 0.413 | 0.828 | 0.363 |
HOMA-IR | 1.24 (0.38–4.04) | 1.34 ± 0.79 | 1.35 (0.48–4.04) | 1.24 ± 0.66 | 1.000 | 1.000 | 1.000 |
HOMA-IS | 0.81 (0.25–2.63) | 0.83 (0.37–2.63) | 0.75 (0.25–2.10) | 0.92 (0.35–3.91) | 1.000 | 1.000 | 1.000 |
HOMA-β (%) | 97.08 (26.25–312.50) | 108.00 (38.00–306.67) | 94.79 (26.25–312.50) | 80.48 ± 41.53 | 0.155 | 0.135 | 0.680 |
Leptin (ng/ml) | 2.43 (0.10–6.39) | 1.57 (0.12–6.17) | 2.48 (0.10–6.39) | 1.16 (0.09–9.02) | 0.753 | 0.398 | 0.849 |
Adiponectin (μg/ml) | 4.64 (2.27–81.80) | 5.22 ± 2.19 | 4.57 (2.58–81.80) | 5.39 ± 3.05 | 0.828 | 0.948 | 0.941 |
FGF21 (pg/ml) | 167.46 (17.82–975.23) | 163.69 (59.31–975.05) | 154.45 (17.82–693.97) | 165.29 (63.19–649.68) | 0.904 | 0.596 | 0.528 |
TNFα (pg/ml) | 10.74 ± 4.13 | 10.51 ± 4.05 | 10.82 ± 4.29 | 15.47 ± 6.65 | 0.013 | 0.002 | 0.801 |
LAR | 0.34 (0.02–2.26) | 0.65 ± 0.78 | 0.38 (0.02–1.81) | 0.19 (0.01–3.19) | 0.648 | 0.673 | 1.000 |