Pediatric pulmonary multisystem langerhans cell histiocytosis: does lung lesion severity affect the outcome?

Table 1 Factors affecting survival in lung LCH

Event	N	%	OS (%)	p	CI	EFS (%)	p	CI
Gender
F	26	39	88	0.99	± 19.9	65.8	0.389	± 13.132
M	41	61	51		± 16.8	89.7		± 9.604
Age group below	24	36	70	0.001	± 19	44	0.032	± 20
Age group above 2-year age	43	64	100			63		± 17
Lung with RO +	20	30	57	0	± 23	35	0.001	± 21
Lung with RO-	47	70	100			65		± 16
Risk stratification
MS RO +	20	30	63.8	0	± 21.6	35	0.007	± 20.9
MS RO-	37	55	100			63		± 18.2
USMF	6	9	100			60		± 42.9
USUF	4	6	100			100
Clinical respiratory manifestations	8	12	91	0.2	± 7.6	12.5	0	± 13.9
No respiratory	59	88	75		± 29.9	62.4		± 22.9
Radiological triad of lung severity severe	24	36	78	0.088	± 17	38	0.002	± 20.7
Mild	43	64	95		± 6.46	66		± 16.2
Radiological diffuse lesions	38	57	83.6	0.067	± 12.15	42.4	0.008	± 17.0
Radiological localized lesions	29	43	96		± 7.056-	75.9		± 17.4
Radiological extensive lesions	26	39	79.6	0.128	± 16.0	43.3	0.013	± 19.9
Radiological mild lesions	41	61	94.9		± 6.86	64.6		± 16.8
Bilateral radiological	44	66	85.7	0.198	± 10.78	49.9	0.103	± 16.268
Unilateral radiological	23	34	95.2		± 9.016	69.8		± 20.58
Chest X ray changes	15	22	80	0.317	± 20.18	26.7	0.001	± 22.344
No Chest X ray changes	52	78	91.4		± 8.036	65.7		± 14.7

CI confidence interval, EFS event free survival, F female, M male, MSRO+ multisystem high risk organ, MSRO− multisystem low risk organ, N number, OS overall survival, p value, USMF unisystem multifocal, USUF unisystem unifocal. Underline is to highlight significant p values

ISSN: 1750-1172