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Table 5 Association between binary retinal vessel density and the presence of composite adverse outcomes

From: Association of preoperative retinal microcirculation and perioperative outcomes in patients undergoing congenital cardiac surgery

 

Model 1

Model 2

Model 3

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

Mean RPC, %

 High (> 52.15)

Reference

 

Reference

 

Reference

 

 Low (≤ 52.15)

2.04 (1.24–3.36)

0.005*

1.91 (1.19–3.07)

0.008*

1.97 (1.08–3.57)

0.027*

Peripapillary RPC, %

 High (> 52.42)

Reference

 

Reference

 

Reference

 

 Low (≤ 52.42)

2.35 (1.46–3.78)

< 0.001*

2.12 (1.34–3.35)

0.001*

2.05 (1.16–3.63)

0.014*

RPC capillary, %

 High (> 47.03)

Reference

 

Reference

 

Reference

 

 Low (≤ 47.03)

2.71 (1.27–3.40)

0.003*

1.89 (1.18–3.03)

0.008*

1.72 (1.08–2.74)

0.023*

Peripapillary capillary, %

 High (> 48.37)

Reference

 

Reference

 

Reference

 

 Low (≤ 48.37)

2.23 (1.35–3.67)

0.002*

2.19 (1.33–3.60)

0.002*

1.99 (1.25–3.17)

0.004*

Mean SCP, %

 High (> 50.04)

Reference

 

Reference

 

Reference

 

 Low (≤ 50.04)

1.63 (0.99–2.68)

0.053

1.51 (0.95–2.41)

0.084

1.48 (0.91–2.41)

0.117

SCP-parafovea, %

 High (> 52.42)

Reference

 

Reference

 

Reference

 

 Low (≤ 52.42)

1.79 (1.03–3.11)

0.038*

1.47 (0.87–2.50)

0.149

1.60 (0.95–2.70)

0.078

SCP-perifovea, %

 High (> 50.40)

Reference

 

Reference

 

Reference

 

 Low (≤ 50.40)

1.67 (1.02–2.74)

0.042*

1.59 (1.00-2.52)

0.052

1.60 (1.00-2.58)

0.052

Mean DCP, %

 High (> 55.48)

Reference

 

Reference

 

Reference

 

 Low (≤ 55.48)

2.46 (1.23–4.92)

0.011*

2.38 (1.23–4.61)

0.010*

2.17 (1.08–4.37)

0.029*

DCP-parafovea, %

 High (> 57.75)

Reference

 

Reference

 

Reference

 

 Low (≤ 57.75)

2.02 (1.13–3.62)

0.018*

2.02 (1.16–3.52)

0.013*

1.87 (1.06–3.30)

0.031*

DCP-perifovea, %

 High (> 57.43)

Reference

 

Reference

 

Reference

 

 Low (≤ 57.43)

2.33 (1.17–4.67)

0.017*

2.32 (1.21–4.44)

0.011*

2.16 (1.09–4.25)

0.026*

  1. Model 1: univariate; Model 2: adjusted for age, sex and body mass index; Model 3: adjusted each factor for model 2 plus cyanosis, previous sternotomy, STAT mortality category and cardiopulmonary bypass time
  2. Retinal vessel density is divided into two categories according to cut-off points at the point of maximal sum of sensitivity and specificity using the receiver operating characteristic (ROC) curve
  3. Abbreviations: RPC, radial peripapillary capillary; SCP, superficial capillary plexus; DCP, deep capillary plexus; OR, odds ratio; CI, confidence intervals; STAT, Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery
  4. *Significant statistical difference, P < 0.05