Laboratory reference interval | Controls (n = 20) | HHT-patients (n = 22) | p-values | |
---|---|---|---|---|
Platelet count, 109/L | F: 145–350; M:165–400 | 254 (IQR 230–287) | 288 (IQR 250–381) | 0.046 |
Mean platelet volume, fL (SD) | 6–11 | 9.5 (IQR 9.1–10.4) | 9.6 (IQR 9.2–10.0) | 0.93 |
Immature platelet fraction, % | 0.011–0.061 | 0.025 (IQR 0.016–0.041) | 0.027 (IQR 0.018–0.035) | 0.90 |
Fibrinogen µmol/L | 5.5–11.5 | 8.7 (± 1.6) | 9.9 (± 1.6) | 0.27 |
D-dimer, mg/L FEU | 0-55y: < 0.5; 55–65y: ≤ 0.6; 65–75y: ≤ 0.7; 75–85y: ≤ 0.8 85–95y: ≤ 0.9 | 0.20 (IQR 0.19–0.34) | 0.37 (IQR 0.19–0.53) | 0.91 |
INR (factor II + VII + X) | 0.9–1.1 | 1.0 (IQR 1–1.01) | 1.0 (IQR 1–1.05) | 0.72 |
APTT, seconds | 27–40 | 24 (± 1) | 24 (± 2) | 0.54 |
Folate, nmol/L | > 7 | 13.5 (IQR 11–20) | 15.0 (IQR 9–29) | 0.71 |
Haemoglobin, mmol/L | F: 7.3–9.5, M: 8.3–10.5 | 8.8 (± 0.8) | 7.2 (± 1.5) | 0.0001 |
MCV, fL | 85–100 | 88.5 (IQR 85–91) | 86 (IQR 81–93) | 0.38 |
Reticulocytes, 109/L | F: 29–103, M:32–112 | 65 (IQR 51–80) | 84 (IQR 73–118) | 0.008 |
MCHC, mmol/L | 19.7–22.2 | 21.2 (IQR 21.1–21.6) | 20.3 (IQR 19.4–21.0) | 0.33 |
Iron, µmol/L | 9–34 | 20 (IQR 14–24.5) | 8 (IQR 5–12.5) | 0.0048 |
Ferritin, µg/L | F: 15–180, M: 15–560 | 73.5 (IQR 47–123) | 37.5 (IQR 22–68) | 0.015 |
Transferrin, µmol/L | 25–45 | 33 (IQR 31–35) | 37 (IQR 32–40) | 0.034 |
Transferrin saturation, % | F: 0.1–0.5, M:0.15–0.57 | 0.29 (IQR 0.2–0.37) | 0.11 IQR (0.05–0.18) | 0.19 |
White blood cell count, 109/L | 3.5–8.8 | 5.8 (± 1.1) | 5.8 (± 1.8) | 0.89 |
Creatinine, µmol/L | F: 45–90, M: 60–105 | 69 (IQR 64–78) | 72 (IQR 66–83) | 0.44 |
Albumin, g/L | 15–40 y: 36–50, 40–70 y: 36–48, ≥ 70 y: 34–45 | 48 (IQR 46–50) | 45 (IQR 43–47) | 0.002 |
Alanine aminotransferase, U/L | F: 10–45, M: 10–70 | 24 (IQR 19–31) | 22 (IQR 19–28) | 0.70 |
Gamma-glutamyl transferase, U/L | F: 18-40y:10–45, > 40y: 10–75, M: < 40: 10–80, > 40: 15–115 | 16.5 (IQR 13–20.5) | 29.0 (IQR 18–56) | 0.038 |
Alkaline phosphatase, U/L | 35–105 | 65 (IQR 56–71) | 83 (IQR 65–90) | 0.053 |
Bilirubin, µmol/L | 5–25 | 8 (IQR 7.8–11) | 6 (IQR 4–9.3) | 0.0035 |
Potassium, mmol/L | 3.5–4.4 | 3.9 (± 0.2) | 4.0 (± 0.35) | 0.50 |
Sodium, mmol/L | 137–145 | 139.6 (± 1.6) | 139.1 (± 2.5) | 0.48 |
Calcium ionized, mmol/L | 1.18–1.32 | 1.3 (± 0.03) | 1.2 (± 0.05) | 0.68 |
Lactate dehydrogenase, U/L | < 70y: 105–205, > 70y: 115–255 | 189 (± 24) | 192 (± 32) | 0.74 |
Cobalamin, pmol/L | 200–600 | 288 (IQR 253–317) | 281 (IQR 240–424) | 0.92 |