Table 1 Demographics of symptomatic patients according to genotype category
Overall (n = 4428) | ATTRwt amyloidosis (n = 1410) | V30M early onset (n = 1082) | V30M late onset (n = 670) | Non-V30M (n = 1264) | |
|---|---|---|---|---|---|
Male, n (%) | 3137 (70.8) | 1315 (93.3) | 565 (52.2) | 433 (64.6) | 822 (65.0) |
Race/ethnicitya, n (%) | |||||
White | 2450 (77.2) | 1141 (94.1) | 263 (68.3) | 382 (83.2) | 663 (59.5) |
African descent | 310 (9.8) | 38 (3.1) | 33 (8.6) | 18 (3.9) | 221 (19.8) |
American Hispanic | 17 (0.5) | 1 (0.1) | 10 (2.6) | 1 (0.2) | 5 (0.4) |
Latino American | 136 (4.3) | 8 (0.7) | 22 (5.7) | 4 (0.9) | 102 (9.1) |
Asian | 245 (7.7) | 18 (1.5) | 56 (14.5) | 53 (11.5) | 118 (10.6) |
Other | 14 (0.4) | 6 (0.5) | 1 (0.3) | 1 (0.2) | 6 (0.5) |
Age at enrollment (years), mean (SD) | 62.5 (17.22) | 77.9 (7.14) | 40.6 (9.44) | 68.6 (7.94) | 60.9 (13.22) |
Age at onset of ATTR amyloidosis symptoms (years) | n = 4421 | n = 1409 | n = 1082 | n = 670 | n = 1259 |
Mean (SD) | 56.6 (17.93) | 72.3 (9.73) | 33.8 (7.19) | 63.3 (8.14) | 55.0 (13.88) |
Time from symptom onset to diagnosis (years) | n = 4069 | n = 1337 | n = 993 | n = 596 | n = 1142 |
Mean (SD) | 4.0 (5.96) | 4.6 (6.73) | 2.8 (4.74) | 3.7 (3.96) | 4.4 (6.61) |
Follow-up timeb (years), mean (SD) | 3.9 (3.20) | 2.3 (1.94) | 6.8 (3.29) | 4.1 (3.03) | 3.2 (2.61) |