Table 1 Top 10 pathways from pathway ORA from the Psychiatric Group (Table 1A) and that from the Nonpsychiatric Group (Table 1B). The pathways displayed here were ranked based on z score among those with at least three genes matching the criteria (p value < 0.05 and |log2FC| >= 0.15). Full lists are provided as Supplemental Material S5
From: Exploring pathway interactions to detect molecular mechanisms of disease: 22q11.2 deletion syndrome
wpid | pathway description | z score | p value |
|---|---|---|---|
A | |||
WP4657 | 22q11.2 copy number variation syndrome | 10.95 | < 0.01 |
WP5001 | Transcriptional regulation of granulopoiesis | 6.81 | < 0.01 |
WP2328 | Allograft Rejection | 6.30 | < 0.01 |
WP4066 | Interleukin-4 and Interleukin-13 signaling | 6.26 | < 0.01 |
WP3358 | Caspase activation via Death Receptors in the presence of ligand | 5.80 | < 0.01 |
WP1829 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 5.17 | < 0.01 |
WP3658 | Wnt/beta-catenin Signaling Pathway in Leukemia | 4.06 | 0.01 |
WP3350 | TNFs bind their physiological receptors | 3.85 | < 0.01 |
WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway | 3.84 | < 0.01 |
WP4900 | Purinergic signaling | 3.59 | < 0.01 |
B | |||
WP4657 | 22q11.2 copy number variation syndrome | 14.71 | < 0.01 |
WP5001 | Transcriptional regulation of granulopoiesis | 8.67 | < 0.01 |
WP4101 | Antimicrobial peptides | 7.06 | < 0.01 |
WP3391 | Senescence-Associated Secretory Phenotype (SASP) | 6.45 | < 0.01 |
WP3359 | DNA methylation | 6.24 | < 0.01 |
WP3364 | SIRT1 negatively regulates rRNA expression | 5.91 | < 0.01 |
WP3397 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | 5.80 | < 0.01 |
WP3312 | PRC2 methylates histones and DNA | 5.52 | < 0.01 |
WP3801 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 5.34 | < 0.01 |
WP4049 | Neutrophil degranulation | 5.24 | < 0.01 |