Fig. 5
From: Exploring pathway interactions to detect molecular mechanisms of disease: 22q11.2 deletion syndrome
A summary of workflow. First, we created two subgroup datasets (Psychiatric vs. Nonpsychiatric) and conducted a differential expression analysis for each set. Next, the pathway interaction method and pathway over representation analysis (ORA) were applied to each set of differential expression analysis results. Relevant genes and biological processes associated with neuropsychiatric diseases were identified by comparing the results from the pathway interaction method and pathway over representation analysis, respectively, by creating relevant networks. Finally, subnetworks from the two methods were compared and discussed. (ASD = autism spectrum disorder, 22q11DS = 22q11.2 deletion syndrome)