Fig. 2
From: Exploring pathway interactions to detect molecular mechanisms of disease: 22q11.2 deletion syndrome
Neuropsychiatric genes detected by the pathway interaction network and their subnetwork. Figure 2A indicates the neuropsychiatric genes detected by two groups. The Psychiatric Group identified 12 exclusive neuropsychiatric genes, based on the classification in DisGeNet, included in the interaction network. Using this exclusive list of genes and two additional first-degree neighbors (CRKL and GRAP2), we were able to create a fully connected neuropsychiatric disease expression subnetwork shown in Fig. 2B. The 22q11DS pathway node was included to show its connection with CRKL. Supplementary Material S4 provides the full list of pathways that contain the detected genes